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Aclarubicin

More information in Books or onNLM PubMed
Definition: An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.     
Pharmacological Action Antibiotics, Antineoplastic
Other names Aclacinomycin A; NSC208734; NSC 208734; MA144A1; NSC-208734; Medac Brand of Aclarubicin Hydrochloride; MA 144A1; MA-144A1; Lundbeck Brand of Aclarubicin Hydrochloride; Aclaplastin; Aclacin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
10-decarboxymethylaclacinomycin T  0   Aclarubicin/*analogs & derivatives. J Biol Chem 2003 Oct 3;278(40):39006-13
15-demethoxyaclacinomycin T  0   Aclarubicin/*analogs & derivatives. J Biol Chem 2003 Oct 3;278(40):39006-13
BHAC-AMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Prednisolone 6-Mercaptopurine Aclarubicin. Int J Hematol 2001 Jul;74(1):53-7
CAG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Aclarubicin Granulocyte Colony-Stimulating Factor. Int J Hematol 2000 Apr;71(3):238-44
CAOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisolone Vincristine Aclarubicin. Cancer Genet Cytogenet 1996 Aug;90(1):45-8
11-hydroxyaclacinomycin X  0   Aclarubicin/*analogs & derivatives. J Antibiot (Tokyo) 1996 Apr;49(4):355-60
11-hydroxyaclacinomycin A  0   Aclarubicin/*analogs & derivatives. Antimicrob Agents Chemother 1995 Jul;39(7):1616-20
2-hydroxyaclacinomycin B  85819-82-5   Aclarubicin/*analogs & derivatives. Jpn J Antibiot 1991;44(3):277
BGM 84 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Aclarubicin. Nouv Rev Fr Hematol 1990;32(2):147
ABEP protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Etoposide Prednisolone Aclarubicin. Cancer Chemother Pharmacol 1989;25(2):135
AB-triple V protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Etoposide Vinblastine Vincristine Aclarubicin. Rinsho Ketsueki 1989;30(2):169
AclBEP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Prednisolone Aclarubicin. Nippon Gan Chiryo Gakkai Shi 1987;22(6):1176
CAP therapy protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Aclarubicin Peplomycin. Nippon Sanka Fujinka Gakkai Zasshi 1986;38(11):2119
BH-AC-AMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Prednisolone 6-Mercaptopurine Aclarubicin. Rinsho Ketsueki 1984;25(11):1766
6-O-methylaclacinomycin  76264-92-1   Aclarubicin/*analogs & derivatives. J Antibiot (Tokyo):1981;34(7):905
4-O-methylaclacinomycin  76304-86-4 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5-dihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-4-O-(2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-L-lyxo-hexopy  Aclarubicin/*analogs & derivatives. J Antibiot (ToKyo) 1981;34(7):905
aclacinomycins  0   Aclarubicin/*analogs & derivatives.
Pharma Action Adjuvants, Immunologic ; Antibiotics, Antineoplastic
Antibiot Chemother 23:76;1978; Biochem Biophys Res Commun 82(1):188;1978; Biochemistry 1979;18(18):4024; Cancer Res 38:1782;1978; Cancer Treat Rep 63(5):875;1979; Cancer Treat Rep 63(5):931;1979; Folia Microbiol 23:152;1978; Gann 68(5):685;1977; J Antibiot (Tokyo) 32(1):48;1979; J Antibiot 1979;32(5):472; J Antibiotics 28(10):830;1975; J Antibiotics 31(9):919;1978; Jpn J Antibiot 30 suppl:S-70;1977; Lancet 2(8137):301;1979; Recent Results Canc Res 63:241;1978
2-hydroxyaclacinomycin A  79127-36-9 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7,9-tetrahydroxy-6,11-dioxo-4-((2,3,6-trideoxy-4-O-(2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-L-lyxo-hexopyran  Aclarubicin/*analogs & derivatives. J Antibiot (Tokyo) 1981;34(11):1494

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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