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Epirubicin

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Definition: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.     
Pharmacological Action Antibiotics, Antineoplastic 		Other names 4'-Epidoxorubicin; 4'-Epiadriamycin; 4' Epi Doxorubicin; 4' Epi DXR; 4' Epi Adriamycin; cell pharm Brand of Epirubicin; Pharmorubicin; Pfizer Brand of Epirubicin Hydrochloride; NSC-256942; Lemery Brand of Epirubicin Hydrochloride; Kenfarma Brand of Epirubicin Hydrochloride; IMI-28; Farmorubicine; Farmorubicina; Farmorubicin; Epirubicin Hydrochloride; Epilem; Ellence; EPI-cell; 4'-Epi-DoxorubicinDrugs* : ELLENCE; EPIRUBICIN HYDROCHLORIDE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NC 6300  0   *Proteins Epirubicin/*analogs & derivatives Polyethylene Glycols. Cancer Sci 2011 Jan;102(1):192-9
PET regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Epirubicin Paclitaxel. Ann Oncol 2009 Jul;20(7):1185-92
nitric oxide-pegylated epirubicin  0   *Polyethylene Glycols Epirubicin/*analogs & derivatives. FASEB J 2006 Apr;20(6):765-7
ECarboX protocol  0   Epirubicin *Antineoplastic Combined Chemotherapy Protocols Deoxycytidine/analogs & derivatives Carboplatin. Br J Cancer. 2006 Jan 16;94(1):74-8
FEN protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Vinblastine/*analogs & derivatives Epirubicin. Anticancer Res. 2005 Nov-Dec;25(6C):4493-8
CE protocol II  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Epirubicin. J Clin Oncol. 2005 Oct 1;23(28):6908-18
EDP protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Epirubicin Taxoids. Br J Cancer 2004 Jul 5;91(1);18-22
PELF protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Glutathione Epirubicin Levoleucovorin. Br J Cancer 2004 Apr 19;90(8):1521-5
OPP-EBV-CAD regimen  0   *Antineoplastic Combined Chemotherapy Protocols Prednisone Vincristine Vindesine Epirubicin. Leuk Lymphoma 2000 Dec;40(1-2):87-94
GET protocol  0   Epirubicin *Antineoplastic Combined Chemotherapy Protocols Deoxycytidine/analogs & derivatives Taxoids. Semin Oncol 2001 Apr;28(2 Suppl 7):15-7
ET protocol  0   *Antineoplastic Combined Chemotherapy Protocols Epirubicin Paclitaxel. J Clin Oncol 2001 Apr 15;19(8):2222-31
FLEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Epirubicin Carboplatin. Ann Oncol 2000 May;11(5):569-73
CCA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Epirubicin Carboplatin. Chung Hua Fu Chan Ko Tsa Chih 1998 Jun;33(6):358-60
EEPFL protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Leucovorin Etoposide Fluorouracil Epirubicin. Jpn J Clin Oncol 2000 Mar;30(3):122-5
EBVD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Dacarbazine Vinblastine Epirubicin. Leuk Lymphoma 2000 Mar;37(1-2):131-43
CYVEDIC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dacarbazine Vincristine Epirubicin. Tumori 1999 Nov-Dec;85(6):512-4
ECT chemotherapy protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Quinazolines Thiophenes Epirubicin. Eur J Cancer 1999 Mar;35 Suppl 1:S14-8
CEVBP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Prednisolone Vincristine Epirubicin. J Korean Med Sci 1999 Oct;14(5):565-70
MPEpiV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Methotrexate Vincristine Epirubicin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
MPEpiE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Methotrexate Epirubicin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
ELFE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Etoposide Fluorouracil Epirubicin. Am J Clin Oncol 1999 Jun;22(3):262-6
FDE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dacarbazine Fluorouracil Epirubicin. Cancer 1998 Jul 15;83(2):372-8
epidoxoform  0   Epirubicin/*analogs & derivatives. J Med Chem 1998 Apr 9;41(8):1306-14
MEP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Epirubicin Mitomycin. Oncology 1998 Mar-Apr;55(2):116-21
CEOP protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisolone Vincristine Epirubicin. Ann Oncol 1996 Dec;7(10):1029-36
ProMECE-CytaBOM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Cytarabine Etoposide Methotrexate Prednisone Vincristine Epirubicin. Haematologica 1995 Sep-Oct;80(5):416-20
EID protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dacarbazine Ifosfamide Epirubicin. Am J Clin Oncol 1996 Feb;19(1):78-81
VIE protocol  0   Mesna *Antineoplastic Combined Chemotherapy Protocols Ifosfamide Vincristine Epirubicin. Eur J Cancer 1995 Oct;31A(11):1773-7
CEOP-B protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Prednisone Vincristine Epirubicin. J Clin Oncol 1995 Apr;13(4):953-60
IEV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Ifosfamide Epirubicin. Haematologica 1994 Nov-Dec;79(6):508-12
FEMTX protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Methotrexate Epirubicin. Br J Cancer 1995 Mar;71(3):587-91
m-BECOD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Leucovorin Cyclophosphamide Dexamethasone Methotrexate Vincristine Epirubicin. Leuk Lymphoma 1994 Sep;15(1-2):153-7
VIC-E protocol  0   Etoposide Ifosfamide Epirubicin Carboplatin *Antineoplastic Combined Chemotherapy Protocols. Semin Oncol 1995 Feb;22(1 Suppl 2):3-8
VIP-E protocol  0   Etoposide *Antineoplastic Combined Chemotherapy Protocols Cisplatin Ifosfamide Epirubicin. Semin Oncol 1995 Feb;22(1 Suppl 2):3-8
MEC protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Methotrexate Epirubicin. Cancer Chemother Pharmacol 1994;35 Suppl:S9-13
VEBEP regimen  0   Bleomycin *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Prednisone Epirubicin. Int J Radiat Oncol Biol Phys 1994 Nov 15;30(4):813-9
EAP-II protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Epirubicin Carboplatin. Gan To Kagaku Ryoho 1994 Sep;21(13):2253-5
CEE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Epirubicin. Lung Cancer 1993 Dec;10(3-4):199-208
CEO-PE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Vincristine Epirubicin Carboplatin. Lung Cancer 1993 Dec;10(3-4):199-208
VEMP protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Methylprednisolone Vincristine Epirubicin. Cancer Chemother Pharmacol 1994;34(4):356-60
FLEP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Epirubicin. Ann Oncol 1993 Nov;4(9):753-7
EVDAC regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Dexamethasone Vincristine Epirubicin. Blood 1993 Dec 15;82(12):3564-73
CEF regimen  0   Cytarabine *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Epirubicin. Oncology 1993 Nov-Dec;50(6):460-5
P-DOCE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Prednisone Vincristine Epirubicin. J Clin Oncol 1993 Nov;11(11):2250-7
FEMTX-P protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Methotrexate Epirubicin. Ann Oncol 1993 May;4(5):426-8
Carbo-MVE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Methotrexate Vinblastine Epirubicin Carboplatin. Ann Oncol 1993 Apr;4(4):313-6
CEFT protocol  0   Tamoxifen *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Fluorouracil Epirubicin. Gan To Kagaku Ryoho 1993 Jun;20(8):1067-70
P-VEBEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Etoposide Prednisone Vinblastine Epirubicin. Hematol Oncol 1993;11 Suppl 1:52-8
IEVM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Ifosfamide Methotrexate Epirubicin. Ann Hematol 1993 Mar;66(3):135-7
FPEPIR regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Epirubicin. Am J Clin Oncol 1993 Apr;16(2):96-101
EEP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Etoposide Epirubicin. Ann Oncol 1992 Dec;3(10):861-3
CEVP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Etoposide Epirubicin. Tumori 1992 Oct 31;78(5):333-7
EMB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Methotrexate Epirubicin. Tumori 1992 Oct 31;78(5):330-2
N-(3-pyridylmethyl)dihydroepidoxorubicin  145785-63-3   Epirubicin/*analogs & derivatives. J Chemother 1992 Oct;4(5):306-11
N-(3-pyridylmethyl)epidoxorubicin  145843-38-5 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-((2,3,6-trideoxy-3-((3-pyridinylmethyl)amino)-alpha-L-arabino-hexopyranosyl)oxy)-, (8S-cis)  Epirubicin/*analogs & derivatives. J Chemother 1992 Oct;4(5):306-11
PE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Epirubicin. Cancer Chemother Pharmacol 1992;30(3):212-4
epidoxorubicin glucuronide  0   *Glucuronates Epirubicin/*analogs & derivatives. J Chromatogr 1991 Dec 6;572(1-2):211-7
VEEP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Prednisolone Vincristine Epirubicin. Br J Cancer 1992 May;65(5):756-60
CEOP-MB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Leucovorin Cyclophosphamide Methotrexate Prednisone Vincristine Epirubicin. J Chemother 1991 Aug;3(4):260-3
CEOP-IMVP-Dexa regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Etoposide Ifosfamide Methotrexate Prednisolone Vincristine Epirubicin. Hematol Oncol 1991 Jul-Oct;9(4-5):209-15
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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