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Tachykinins

More information in Books or onNLM PubMed
Definition: A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.  GEN or unspecified; prefer specifics   
Pharmacological Action Neurotransmitter Agents
See Also Receptors, Tachykinin
Examples Eledoisin; Kassinin; Neurokinin A; Neurokinin B; Physalaemin; Substance P 		Other names Tachykinin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
neuropeptide S precursor protein, human  0   *Tachykinins. Sleep Breath. 2011 Sep;15(3):403-9
endokinin C-D, human  0   *Peptide Fragments *Tachykinins. Peptides 2010 Jan;31(1):94-100
endokinin A-B, human  0   *Peptide Fragments *Tachykinins. Peptides 2010 Jan;31(1):94-100
preproneurokinin-C, mouse  0   *Protein Precursors *Tachykinins. J Pathol 2006 Feb;208(3):364-71
hemokinin-1  0   *Tachykinins. Neurosci Lett. 2006 Jan 9;392(1-2):114-7
TAC4 protein, human  0   *Tachykinins.
Tac4 protein, mouse  0   *Protein Precursors *Tachykinins. Nat Immunol 2000 Nov;1(5):392-7
Dtk protein, Drosophila  0   *Protein Precursors *Tachykinins *Drosophila Proteins. J Biol Chem 2000 Jul 28;275(30):23273-80
LemTRP-1 protein, Leucophaea maderae  0   *Tachykinins *Insect Proteins. Regul Pept 1998 Apr 24;74(1):61-6
gal (1-14)-(Abu 8) scy-I  0   *Tachykinins *Galanin. Acta Physiol Hung 1996;84(4):429-31
MDL 105,172a  0   *Morpholines *Piperidines Tachykinins/antagonists & inhibitors. J Auton Pharmacol 1997 Apr;17(2):109-19
TAC 363  0   *Oligopeptides Tachykinins/antagonists & inhibitors. Yakugaku Zasshi 1996 Nov;116(11):884-91
PG-KII peptide  0   *Tachykinins Pyrrolidonecarboxylic Acid/*analogs & derivatives. Peptides 1996;17(4):729-31
callitachykinin II  158275-31-1 Callitachykinin II  *Tachykinins. Peptides 1994;15(5):761-8
callitachykinin I  158275-30-0 Callitachykinin I  *Tachykinins. Peptides 1994;15(5):761-8
sialokinin II  152923-42-7 Physalemin, 1-de(5-oxo-L-proline)-2-L-aspartic acid-3-L-threonine-4-glycine-5-L-aspartic acid  Tachykinins. Proc Natl Acad Sci U S A 1994 Jan 4;91(1):138-42
sialokinin I  152923-41-6 Physalemin, 1-de(5-oxo-L-proline)-2-L-asparagine-3-L-threonine-4-glycine-5-L-aspartic acid  *Tachykinins. Proc Natl Acad Sci U S A 1994 Jan 4;91(1):138-42
ranatachykinin D  135690-50-5 Ranatachykinin D  *Tachykinins. Regul Pept 1993 Jul 2;46(1-2):81-8
ranatachykinin C  135690-49-2 Phyllomedusin, 1-L-histidine-4-L-alanine-5-L-serine  *Tachykinins. Regul Pept 1993 Jul 2;46(1-2):81-8
ranatachykinin B  135690-48-1 Kassinin, 1-de-L-aspartic acid-2-de-L-valine-3-L-tyrosine-7-L-serine-9-L-tyrosine  *Tachykinins. Regul Pept 1993 Jul 2;46(1-2);81-8
ranatachykinin A  135690-47-0 Eledoisin, 1-L-lysine-4-L-proline-6-L-arginine-8-L-tyrosine  *Tachykinins. Regul Pept 1993 Jul 2;46(1-2):81-8
locustatachykinin IV protein, insect  132309-71-8   *Tachykinins *Insect Proteins. Regul Pept 1990;31(3):199
locustatachykinin III protein, insect  132309-70-7   *Tachykinins *Insect Proteins. Regul Pept 1990;31(3):199
carassin  133950-47-7   *Tachykinins. J Neurochem 1991;56(4):1432
beta-preprotachykinin (111-126)  114547-33-0   *Peptide Fragments *Protein Precursors *Tachykinins. Peptides 1990;11(5):907
locustatachykinin II protein, Locusta migratoria  126985-98-6 Tachykinin I (Locusta migratoria), 1-L-alanine-2a-endo-L-leucine  *Tachykinins *Insect Proteins. FEBS Lett 1990;261(2):397
locustatachykinin I protein, Locusta migratoria  126985-97-5 Tachykinin I (Locusta migratoria)  *Tachykinins *Insect Proteins. FEBS Lett 1990;261(2):397
ranamargarin  132151-82-7   *Tachykinins. Sci China (B) 1989;32(5):570
tachykinin neuropeptide gamma  114882-65-4   *Peptide Fragments *Tachykinins Neuropeptides. Eur J Pharmacol 1989;161(2-3):267
scyliorhinin II (3-18)  117354-73-1   *Tachykinins *Peptide Fragments Torpedo. Gen Comp Endocrinol 1988;71(3):383
protachykinin  0   *Protein Precursors *Tachykinins. Adv Exp Med Biol 1987;221:385
scyliorhinin II  112748-19-3   *Tachykinins Radioligand Assay. FEBS Lett 1986;200(1):111
scyliorhinin I  103425-21-4   *Tachykinins. FEBS Lett 1986;200(1):111
neuropeptide K  0   *Tachykinins. Biochem Biophys Res Commun 1985;128(2):947
preprotachykinin  0   *Protein Precursors *Tachykinins. Nature 1983;306(5938):32

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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