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Cilastatin

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Definition: A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.     
Pharmacological Action Protease Inhibitors 		Other names Sodium, Cilastatin; Salt, Cilastatin Monosodium; Monosodium Salt, Cilastatin; MK791; MK 791; 0791, MK; MK0791; MK 0791; Cilastatin Sodium; Cilastatin Monosodium Salt; MK-791
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-acetylcilastatin  94388-32-6   Cilastatin/*analogs & derivatives. Drug Metab Dispos 1989;17(4):426
cilastatin, imipenem drug combination  92309-29-0   *Imipenem *Cilastatin Drug Combinations. J Antimicrob Chemother 1985;15(2):233PRIMAXIN; IMIPENEM AND CILASTATIN

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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