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Signal Transduction

More information in Books or onNLM PubMed
Definition: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinas     
See Also Ion Channels
Examples Ion Channel Gating; Light Signal Transduction; MAP Kinase Signaling System; Mechanotransduction, Cellular; Second Messenger Systems; Synaptic Transmission 		Other names Signal Pathways; Receptor-Mediated Signal Transduction; Transductions, Signal; Transduction, Signal; Systems, Signal Transduction; System, Signal Transduction; Signal Transductions, Receptor-Mediated; Signal Transductions; Signal Transduction, Receptor-Mediated; Signal Transduction System; Signal Transduction Pathway; Signal Pathway; Receptor-Mediated Signal Transductions; Pathways, Signal Transduction; Pathways, Signal; Pathway, Signal Transduction; Pathway, Signal; Signal Transduction Systems; Signal Transduction Pathways; Receptor Mediated Signal Transduction
 
SubstanceCAS Registry & nameCategoriesSource
Lck-interacting protein, human  0   *Adaptor Proteins, Vesicular Transport Signal Transduction. Immunol Lett. 2009 Feb 21;122(2):185-92
synembryn-like protein, zebrafish  0   *Nuclear Proteins *Zebrafish Proteins Signal Transduction. Development 2008 Jan;135(1):159-69
ARL protein, Arabidopsis  0   *Membrane Proteins *Arabidopsis Proteins Signal Transduction. Plant J 2006 Jul;47(1):1-9
BKI1 protein, Arabidopsis  EC 2.7.1.37   *Protein Kinases *Arabidopsis Proteins Signal Transduction. Science. 2006 Aug 25;313(5790):1118-22
FOXH1 protein, human  0   *Forkhead Transcription Factors Signal Transduction.
notchless protein, mouse  0   *Membrane Proteins Signal Transduction. Mol Cell Biol. 2006 May;26(9):3541-9
DJ-1 protein, mouse  0   *Oncogene Proteins Signal Transduction. Brain Res 2005 Apr 11;1041(1):102-11
costal2 protein, zebrafish  0   *Kinesin *Zebrafish Proteins Signal Transduction. Development 2005 Feb;132(4):625-34
RKL1 protein, Arabidopsis  EC 2.7.1.-   *Protein Kinases *Arabidopsis Proteins Signal Transduction. Plant Cell Physiol 2000 Sep;41(9):1038-44
RLK902 protein, Arabidopsis  EC 2.7.1.-   *Protein Kinases *Arabidopsis Proteins Signal Transduction. Biosci Biotechnol Biochem 2004 Sep;68(9):1935-41
TIRAP protein, mouse  0   *Membrane Glycoproteins *Receptors, Interleukin-1 Signal Transduction.
nrarpb protein, zebrafish  0   *Zebrafish Proteins Signal Transduction Ankyrin Repeat.
nrarpa protein, zebrafish  0   *Zebrafish Proteins Signal Transduction Ankyrin Repeat.
Nrarp protein, mouse  0   *Proteins Signal Transduction Ankyrin Repeat.
PIL6 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic Helix-Loop-Helix Transcription Factors Signal Transduction Helix-Loop-Helix Motifs. Plant Cell Physiol 2004 Aug;45(8):1078-86
ARR22 protein, Arabidopsis  0   *Arabidopsis Proteins Signal Transduction. Plant Cell Physiol 2004 Aug;45(8):1063-77
SIMPL protein, mouse  0   *Carrier Proteins Signal Transduction. Mol Cell Biol 2004 Nov;24(21):9317-26
RGS7 protein, human  0   *RGS Proteins Signal Transduction.
Rgs7 protein, mouse  0   *RGS Proteins Signal Transduction.
Stam protein, mouse  0   *Phosphoproteins *Adaptor Proteins, Signal Transducing *Endosomal Sorting Complexes Required for Transport Signal Transduction src Homology Domains.
Stam2 protein, mouse  0   *Phosphoproteins *Adaptor Proteins, Signal Transducing *Endosomal Sorting Complexes Required for Transport Signal Transduction src Homology Domains.
Sfrp2 protein, mouse  0   *Membrane Proteins Signal Transduction Apoptosis.
SMAD8 protein, human  0   *Smad8 Protein Signal Transduction Transforming Growth Factor beta.
Smad8 protein, Xenopus  0   *Xenopus Proteins *Smad8 Protein Signal Transduction Transforming Growth Factor beta.
Smad9 protein, mouse  0   *Smad8 Protein Signal Transduction Transforming Growth Factor beta.
SF1 protein, S cerevisiae  0   *DNA-Binding Proteins *Transcription Factors *Saccharomyces cerevisiae Proteins Signal Transduction Zinc Fingers.
splicing factor SF1 protein, C elegans  0   *DNA-Binding Proteins *Transcription Factors *Caenorhabditis elegans Proteins Signal Transduction Zinc Fingers.
Zfp162 protein, mouse  0   *DNA-Binding Proteins *Transcription Factors Signal Transduction Zinc Fingers.
Zfp162 protein, rat  0   *DNA-Binding Proteins *Transcription Factors Signal Transduction Zinc Fingers.
Socs3 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction.
Socs3 protein, rat  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction.
Socs2 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction.
Socs2 protein, rat  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction.
Foxh1 protein, mouse  0   *Forkhead Transcription Factors Signal Transduction.
foxh1 protein, zebrafish  0   *Zebrafish Proteins *Forkhead Transcription Factors Signal Transduction.
Madh4 protein, rat  0   *Smad4 Protein Signal Transduction Genes, Tumor Suppressor Transforming Growth Factor beta.
Smad4 protein, mouse  0   *Smad4 Protein Signal Transduction Genes, Tumor Suppressor Transforming Growth Factor beta.
LNK protein, human  0   *Proteins Signal Transduction src Homology Domains.
Lnk protein, mouse  0   *Intracellular Signaling Peptides and Proteins Signal Transduction src Homology Domains.
LSCPR2 protein, Lymnaea stagnalis  0   *Receptors, Vasopressin Signal Transduction.
CpxA protein, E coli  EC 2.7.3.-   *Protein Kinases *Escherichia coli Proteins Signal Transduction.
IGBP1 protein, human  0   *Intracellular Signaling Peptides and Proteins Signal Transduction.
Igbp1b protein, mouse  0   *Phosphoproteins Signal Transduction.
ANKK1 protein, human  EC 2.7.1.37   *Protein-Serine-Threonine Kinases Signal Transduction Ankyrin Repeat. Hum Mutat 2004 Jun;23(6):540-5
apx-1 protein, C elegans  0   *Sodium Channels *Caenorhabditis elegans Proteins Signal Transduction.
EvgA protein, E coli  0   *Transcription Factors *Escherichia coli Proteins Signal Transduction.
FRS2alpha protein, mouse  0   *Membrane Proteins Signal Transduction. Mol Cell Biol 2004 Jul;24(13):5657-66
SSK1 protein, Candida albicans  0   *Fungal Proteins Signal Transduction. Yeast 1999 Sep 15;15(12):1243-54
Nfam1 protein, mouse  0   *Membrane Proteins Signal Transduction. Proc Natl Acad Sci U S A 2004 May 25;101(21):8126-31
CesR protein, Listeria monocytogenes  0   *Transcription Factors Signal Transduction. Antimicrob Agents Chemother 2003 Nov;47(11):3421-9
Mapk8ip2 protein, mouse  0   *Adaptor Proteins, Signal Transducing Signal Transduction.
Mfng protein, mouse  0   *Proteins Signal Transduction.
EPS15 protein, human  0   *Calcium-Binding Proteins *Phosphoproteins *Intracellular Signaling Peptides and Proteins Signal Transduction.
PIAS4 protein, human  0   *Protein Inhibitors of Activated STAT Nuclear Proteins Signal Transduction.
Ric8b protein, rat  0   *Nuclear Proteins Signal Transduction.
Ric8a protein, rat  0   *Nuclear Proteins *Guanine Nucleotide Exchange Factors Signal Transduction.
Ngfrap1 protein, rat  0   *Apoptosis Regulatory Proteins Signal Transduction Apoptosis.
Ngfrap1 protein, mouse  0   *Apoptosis Regulatory Proteins Apoptosis Signal Transduction.
Tollip protein, mouse  0   *Intracellular Signaling Peptides and Proteins Signal Transduction.
Rgs11 protein, mouse  0   *RGS Proteins Signal Transduction.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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