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Oncogene Proteins, Fusion

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Definition: The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.  do not confuse with CHIMERIC PROTEINS, RECOMBINANT see RECOMBINANT FUSION PROTEINS or MUTANT CHIMERIC PROTEINS   
Examples Fusion Proteins, bcr-abl; Fusion Proteins, gag-onc; Oncogene Protein tpr-met 		Other names Proteins, Oncogene Fusion; Proteins, Oncogene Chimeric; Proteins, Fusion Oncogene; Proteins, Chimeric Oncogene; Oncogene Chimeric Proteins; Fusion Oncogene Proteins; Oncogene Proteins, Chimeric; Oncogene Fusion Proteins; Fusion Proteins, Oncogene; Chimeric Proteins, Oncogene; Chimeric Oncogene Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NUP98-PSIP1 fusion protein, human  0   *Oncogene Proteins, Fusion *Nuclear Pore Complex Proteins *Adaptor Proteins, Signal Transducing Transcription Factors. Leuk Res. 2011 Jun;35(6):e75-6.
KANK1-PDGFRbeta fusion protein, human  0   *Oncogene Proteins, Fusion Receptor, Platelet-Derived Growth Factor beta Tumor Suppressor Proteins. Haematologica. 2011 Oct;96(10):1406-14.
ESRRA-C11orf20 fusion protein, human  0   *Oncogene Proteins, Fusion Ovarian Neoplasms. PLoS Biol. 2011 Sep;9(9) (dup#2):e1001156
BRAF-KIAA1549 fusion protein, human  0   *Oncogene Proteins, Fusion. Clin Cancer Res. 2011 Jul 15;17(14):4790-8.
PAX7-FKHR fusion protein, human  0   *Oncogene Proteins, Fusion. Pediatr Blood Cancer 2011 Sep;57(3):406-14
EWSR1-ATF1 fusion protein, human  0   *Oncogene Proteins, Fusion. Genes Chromosomes Cancer 2011 Jul;50(7):559-70
FP-1039  0   *Immunoglobulin G *Oncogene Proteins, Fusion *Receptor, Fibroblast Growth Factor, Type 1. Nat Rev Drug Discov. 2011 May;10(5):328
PAX5-AUTS2 fusion protein, human  0   *Oncogene Proteins, Fusion. Leuk Res 2010 Dec;34(12):e323-5
PAX8-PPARgamma fusion protein, human  0   *Oncogene Proteins, Fusion. Mol Cell Endocrinol. 2010 May 28;321(1):50-6
MLL-AF9 fusion protein, mouse  0   *Oncogene Proteins, Fusion Myeloid-Lymphoid Leukemia Protein. Mol Cell 2010 Jun 25;38(6):853-63
ETV6-RUNX1 fusion protein, human  0   *Oncogene Proteins, Fusion. Haematologica. 2010 Feb;95(2):241-6
IGH-MALT1 fusion protein, human  0   *Oncogene Proteins, Fusion Lymphoma, B-Cell, Marginal Zone. Blood. 2010 Mar 18;115(11):2214-9
SIL-TAL1 fusion protein, human  0   *Oncogene Proteins, Fusion. Leuk Lymphoma 2009 Aug;50(8):1239-48
MYB-NFIB fusion protein, human  0   *Oncogene Proteins, Fusion. Proc Natl Acad Sci U S A 2009 Nov 3;106(44):18740-4
NFATc2-EWSR1 fusion protein, human  0   *Oncogene Proteins, Fusion. Clin Cancer Res 2009 Apr 1;15(7):2259-68
TCF3-PBX1 fusion protein, human  0   *Oncogene Proteins, Fusion. Leukemia 2009 Aug;23(8):1406-9
MLL-KIAA0284 fusion protein, human  0   *Oncogene Proteins, Fusion. Blood Cells Mol Dis 2009 May-Jun;42(3):292-3
NUP98-NSD3 fusion protein, human  0   *Oncogene Proteins, Fusion. Cancer Genet Cytogenet 2009 Apr 15;190(2):108-12
MIPOL1-DGKB fusion protein, human  0   *Oncogene Proteins, Fusion. Nature 2009 Mar 5;458(7234):97-101
SLC45A3-ELK4 fusion protein, human  0   *Oncogene Proteins, Fusion. Nature 2009 Mar 5;458(7234):97-101
FIP1L1-RARA fusion protein, human  0   *Oncogene Proteins, Fusion. Haematologica 2008 Sep;93(9):1414-6
EWS-NOR1 fusion protein, human  0   *Oncogene Proteins, Fusion. J Cell Biochem 2008 Oct 15;105(3):785-800
RUNX1-PRDM16 fusion protein, human  0   *Oncogene Proteins, Fusion. Genes Chromosomes Cancer 2008 Dec;47(12):1110-7
OTT-MAL fusion protein, human  0   *Oncogene Proteins, Fusion. Proc Natl Acad Sci U S A 2001 May 8;98(10):5776-9
FUS-DDIT3 fusion protein, human  0   *Oncogene Proteins, Fusion. PLoS ONE 2008;3(7):e2569
TLS-ERG fusion protein, mouse  0   *Oncogene Proteins, Fusion. Mol Cancer Res 2008 May;6(5):862-72
ETV6-GOT1 fusion protein, human  0   *Oncogene Proteins, Fusion. Haematologica 2008 Mar;93(3):467-8)
RBM6-RBM5 fusion protein, human  0   *Oncogene Proteins, Fusion. BMC Genomics. 2007;8() (dup#136):348
ALK-RANBP2 fusion protein, human  0   *Oncogene Proteins, Fusion. Cancer Genet Cytogenet 2007 Jul 15;176(2):107-14
RIF1-PKD1L1 protein, human  0   *Oncogene Proteins, Fusion. Oncogene 2008 May 22;27(23):3345-59
MLL-MLLT3 fusion protein, human  0   *Oncogene Proteins, Fusion. Genes Chromosomes Cancer 2004 Aug;40(4):349-54
TMPRSS2-ETV4 fusion protein, human  0   *Oncogene Proteins, Fusion. Cancer Res 2006 Apr 1;66(7):3396-400
TMPRSS2-ETV1 fusion protein, human  0   *Oncogene Proteins, Fusion. Cancer Genet Cytogenet 2008 May;183(1):21-7
TMPRSS2-ETS fusion protein, human  0   *Oncogene Proteins, Fusion. Lab Invest 2006 Nov;86(11):1099-102
IGH-CCND1 fusion protein, human  0   *Oncogene Proteins, Fusion. Haematologica 2008 Apr;93(4):551-9
AML1-LAF4 fusion protein, human  0   *Oncogene Proteins, Fusion. Oncogene 2008 Apr 3;27(15):2249-56
PAX5-TEL fusion protein, human  0   *Repressor Proteins *Oncogene Proteins, Fusion. Cancer Res 2008 Jan 1;68(1):181-9
Slc45A3-ETV5 fusion protein, human  0   *Oncogene Proteins, Fusion. Cancer Res 2008 Jan 1;68(1):73-80
TMPRSS2-ETV5 fusion protein, human  0   *Oncogene Proteins, Fusion. Cancer Res 2008 Jan 1;68(1):73-80
ETV6-NTRK3 fusion protein, mouse  0   *Oncogene Proteins, Fusion. Cancer Cell 2007 Dec;12(6):542-58
EWS-SP3 fusion protein, human  0   *Oncogene Proteins, Fusion. J Mol Diagn 2007 Sep;9(4):498-509
EWS-FUS protein, human  0   *Oncogene Proteins, Fusion. J Mol Diagn 2007 Sep;9(4):459-63
HOOK3-RET fusion protein, human  0   *Oncogene Proteins, Fusion. Endocr Relat Cancer 2007 Jun;14(2):445-52
PAX3-FKHR fusion protein, human  0   *Oncogene Proteins, Fusion. Cancer Lett 2007 Aug 18;253(2):215-23
EML4-ALK fusion protein, human  0   *Oncogene Proteins, Fusion. Nature 2007 Aug 2;448(7153):561-6
NUP98-NSD1 protein, human  0   *Oncogene Proteins, Fusion. Nat Cell Biol 2007 Jul;9(7):804-12
NUP214-ABL1 fusion protein, human  0   *Oncogene Proteins, Fusion. Haematologica 2007 May;92(5):619-26
NUP98-HOXD13 protein, human  0   *Oncogene Proteins, Fusion. Leukemia 2007 Jun;21(6):1239-48
TMPRSS2-ERG fusion protein, human  0   *Oncogene Proteins, Fusion. Neoplasia 2006 Oct;8(10):885-8
MLL-GAS7 fusion protein  0   *Oncogene Proteins, Fusion. Haematologica 2006 Sep;91(9):1287-8
MLL-SEPT6 fusion protein, human  0   *Oncogene Proteins, Fusion. Cancer Genet Cytogenet 2006 Jul 15;168(2):162-7
PICALM-MLLT10 fusion protein, human  0   *Oncogene Proteins, Fusion Leukemia, Monocytic, Acute. Genes Chromosomes Cancer 2006 Jun;45(6):575-82
H4-PDGFRB fusion protein, human  0   *Oncogene Proteins, Fusion. Haematologica 2004 Oct;89(10):1263-4
MLL-SEPT6 fusion protein, mouse  0   *Oncogene Proteins, Fusion. J Clin Invest 2005 Apr;115(4):919-29
MLL-AF17 fusion protein, human  0   *Oncogene Proteins, Fusion. Int J Hematol 2005 Jul;82(1):38-41
AML1-EVI1 fusion protein, human  0   *Oncogene Proteins, Fusion. Blood. 2005 Sep 15;106(6):2147-55
HMGA2-LPP fusion protein, human  0   *Oncogene Proteins, Fusion *HMGA Proteins. Mol Cancer Res 2005 Feb;3(2):63-70
EML1-ABL1 fusion protein, human  0   *Oncogene Proteins, Fusion. Blood 2005 Jun 15;105(12):4849-52
AML1-FOG2 fusion protein, human  0   *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit. Blood 2005 Jun 1;105(11):4523-6
DAZAP1-MEF2D fusion protein, human  0   *Oncogene Proteins, Fusion. Leukemia 2005 May;19(5):806-13
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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