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1-Methyl-4-phenylpyridinium

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Definition: An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.     
Pharmacological Action Herbicides
See Also MPTP Poisoning 		Other names Cyperquat; N Methyl 4 phenylpyridine; 1 Methyl 4 phenylpyridinium Ion; 1 Methyl 4 phenylpyridinium Chloride; 1 Methyl 4 phenylpyridinium; 1 Methyl 4 phenylpyridine; N-Methyl-4-phenylpyridinium; N-Methyl-4-phenylpyridine; 1-Methyl-4-phenylpyridinium Ion; 1-Methyl-4-phenylpyridinium Chloride; 1-Methyl-4-phenylpyridine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-methyl-4-(2-methylphenyl)pyridinium  111342-39-3   1-Methyl-4-phenylpyridinium/*analogs & derivatives. Ann N Y Acad Sci 1992 May 11;648:323-5
1-methyl-4-cyclohexylpyridinium  122861-46-5   1-Methyl-4-phenylpyridinium/*analogs & derivatives Neurotoxins. Exp Neurol 1990;108(2):141
1-methyl-4-(4'-acetamidophenyl)pyridinium  106362-27-0   1-Methyl-4-phenylpyridinium/*analogs & derivatives Neurotoxins. Exp Neurol 1990;108(2):141

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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