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Retroviridae Proteins, Oncogenic

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Definition: Retroviral proteins that have the ability to transform cells. They can induce sarcomas, leukemias, lymphomas, and mammary carcinomas. Not all retroviral proteins are oncogenic.  IM; coord with specific virus (IM); /drug eff /ultrastruct permitted   
Examples Fusion Proteins, gag-onc; Gene Products, rex; Gene Products, tax; Oncogene Protein gp140(v-fms); Oncogene Protein p21(ras); Oncogene Protein p55(v-myc); Oncogene Protein pp60(v-src); Oncogene Protein v-akt; Oncogene Protein v-cbl; Oncogene Protein v-crk; Oncogene Protein v-maf; Oncogene Proteins v-abl; Oncogene Proteins v-erbA; Oncogene Proteins v-erbB; Oncogene Proteins v-fos; Oncogene Proteins v-mos; Oncogene Proteins v-myb; Oncogene Proteins v-raf; Oncogene Proteins v-rel; Oncogene Proteins v-sis 		Other names Proteins, Oncogenic Retroviridae; Oncogenic Retroviridae Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
v-yes protein, Avian sarcoma virus Y73  EC 2.7.1.112   *Protein-Tyrosine Kinases *Retroviridae Proteins, Oncogenic Proto-Oncogene Proteins c-yes.
p20E protein, human T-cell leukemia virus type II  0   *Viral Envelope Proteins *Retroviridae Proteins, Oncogenic Antigens, Viral Membrane Glycoproteins. Hybridoma 1998 Aug;17(4):347-54
murine leukemia virus protein p2E  0   *Viral Matrix Proteins *Retroviridae Proteins, Oncogenic. J Virol 1994 Mar;68(3):1773-81
HTLV-I p23 protein, Human T-lymphotropic virus 1  0   *Retroviridae Proteins, Oncogenic Human T-lymphotropic virus 1 Biological Markers. J Infect Dis 1993 May;167(5):1021-6
p15E protein, Murine leukemia virus  0   *Viral Envelope Proteins *Retroviridae Proteins, Oncogenic Leukemia Virus, Murine. J Virol 1993 Jan;67(1):294-304
glycoprotein gp70, Feline leukemia virus  0   *Viral Envelope Proteins *Retroviridae Proteins, Oncogenic Vaccines, Synthetic Viral Vaccines. J Am Vet Med Assoc 1991 Nov 15;199(10):1423-7
p21X protein, Human T-lymphotropic virus 1  0   *Retroviridae Proteins, Oncogenic. FEBS Lett 1991;295(1-3):127
v-ski protein, Avian retrovirus  0   *Transcription Factors *Retroviridae Proteins, Oncogenic Nuclear Proteins. J Virol 1991;65(9):4929
P20E protein, Human T-lymphotropic virus 1  0   *Viral Envelope Proteins *Retroviridae Proteins, Oncogenic. Aids Res Hum Retroviruses 1990;6(11):1311
v-Spi-1 protein, Friend spleen focus-forming virus  0   *DNA-Binding Proteins *Retroviridae Proteins, Oncogenic Transcription Factors. Oncogene 1989;4(12):1449
p24 protein, Human T-lymphotropic virus 1  0   *Retroviridae Proteins, Oncogenic HTLV-I Antigens Gene Products, gag. Am J Pathol 1989;135(1):1
gp30 envelope transmembrane protein, Bovine leukemia virus  0   *Viral Envelope Proteins *Retroviridae Proteins, Oncogenic. Acta Virol (Praha) 1989;33(2):113
damavaricin Fc pentyl ether  70940-04-4   *Streptovaricin Retroviridae Proteins, Oncogenic. J Antibiot (Tokyo) 1989;42(5):779
transmembrane protein, Simian immunodeficiency virus  0   *Viral Fusion Proteins *Retroviridae Proteins, Oncogenic *Gene Products, env. Aids 1989;3(1):17
small hydrophobic protein, virus  0   *Retroviridae Proteins, Oncogenic Sarcoma Virus, Woolly Monkey. J Virol 1988;62(7):2347
gp46 protein, Human T-cell leukemia virus type I  0   *Retroviridae Proteins, Oncogenic *Gene Products, env Neoplasm Proteins HTLV-I Antigens. J Virol Methods 1987;18(4):243
CKS 17  99273-04-8   *Peptides Viral Envelope Proteins Retroviridae Proteins, Oncogenic. J Immunol 1987;139(7):2329
px27 protein, human T cell leukemia virus type I  0   *Retroviridae Proteins, Oncogenic Deltaretrovirus. Immunol Lett 1987;14(2):139
v-fgr protein, Feline sarcoma virus  0   *Protein-Tyrosine Kinases *Retroviridae Proteins, Oncogenic. J Virol 1987;61(6):1927
feline leukemia virus protein p15E  0   *Retroviridae Proteins, Oncogenic Leukemia Virus, Feline Viral Envelope Proteins. J Gen Virol 1987;68(Pt 2):507
P26 protein, Human T-lymphotropic virus 2  0   *Retroviridae Proteins, Oncogenic Neoplasm Proteins Human T-lymphotropic virus 2. FEBS Lett 1986;209(2):289
oncogene proteins v-ets  0   *Retroviridae Proteins, Oncogenic Protein-Tyrosine Kinases. Adv Cancer Res 1986;47:99
internal protein p24, Human T-lymphotropic virus 2  0   *Retroviridae Proteins, Oncogenic Neoplasm Proteins Human T-lymphotropic virus 2/immunology. Virology 1985;142(1):206
feline leukemia virus vaccine  0   *Viral Vaccines *Retroviridae Proteins, Oncogenic Leukemia Virus, Feline ISCOMs.
Pharma Action Adjuvants, Immunologic 		Immunology 1985;135(1):591
pancreas leukemia virus-related protein, mouse  0   *Retroviridae Proteins, Oncogenic. Biochem Biophys Res Commun 1984;124(2):344
simian sarcoma virus transformation-specific glycopeptide  0   *Retroviridae Proteins, Oncogenic Proteoglycans Antigens, Viral, Tumor Cell Transformation, Neoplastic Sarcoma Virus, Woolly Monkey Transforming Growth Factors. Virology 1984;136(2):414
asp56-LDH(K)  0   *Antigens, Viral, Tumor *Retroviridae Proteins, Oncogenic Harvey murine sarcoma virus Kirsten murine sarcoma virus L-Lactate Dehydrogenase. Transplant Proc 1984;16(2):449
p10 protein, feline leukemia virus  0   *DNA-Binding Proteins *Retroviridae Proteins, Oncogenic DNA-Binding Proteins. Virology 1984;133(1):137
virus structural protein p15  0   *Retroviridae Proteins, Oncogenic *Gene Products, gag Neoplasm Proteins Retroviridae Human T-lymphotropic virus 2. FEBS Lett 1983;162(2):390
glycoprotein 71, Friend murine leukemia virus  0   *Viral Envelope Proteins *Retroviridae Proteins, Oncogenic Glycoproteins. Proc Natl Acad Sci USA 1982;79(19):5788
phosphoprotein pp105  0   *Phosphoproteins *Retroviridae Proteins, Oncogenic. Biochim Biophys Acta 1983;762(1):86
high-molecular-weight polyprotein, feline sarcoma virus  0   *Protein Kinases *Retroviridae Proteins, Oncogenic Protein Kinases. J Virol 1981;37(2):643
36K protein, Rous sarcoma virus transformed chicken fibroblast  0   *Retroviridae Proteins, Oncogenic *Avian Proteins. J Biol Chem 1981;256(6):3053

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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