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Antigens, CD4

More information in Books or onNLM PubMed
Definition: 55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.  for hematodermic CD4/CD56 neoplasm use LYMPHOMA, NON-HODGKIN   
See Also CD4-CD8 Ratio; HIV Envelope Protein gp120 		Other names Receptors, Surface CD4; CD4 Antigen; T4 Antigens, T-Cell; Receptors, CD4; CD4 Receptors; CD4 Molecule; CD4 Antigens; T4 Antigens, T Cell; T-Cell T4 Antigens; Surface CD4 Receptors; CD4 Receptors, Surface; CD4 Receptor, Surface; Antigens, T-Cell T4; Antigen, CD4; Surface CD4 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CD4 silencer, African green monkey  0   *Silencer Elements, Transcriptional Antigens, CD4/genetics. Immunol Lett 2000 Dec 1;75(1):47-53
CDR3.AME(82-89)  0   *Peptide Fragments *Antigens, CD4 HIV-1. DNA Cell Biol 1999 Nov;18(11):819-28
clenoliximab  0   *Antibodies, Monoclonal Antigens, CD4. Clin Pharmacol Ther 1999 Sep;66(3):246-57
keliximab  0   *Antibodies, Monoclonal Antigens, CD4. Ann Rheum Dis 1999 Jun;58(6):342-9
DAB389CD4  0   *Antigens, CD4 Recombinant Fusion Proteins Immunotoxins. AIDS 1998 May 28;12(8):859-63
13B8-2 monoclonal antibody  0   *Antibodies, Monoclonal Antigens, CD4. J Acquir Immun Defic Syndr Hum Retrovirol 1998 Jan 1;17(1):17-26
RIB 5-2 monoclonal antibody  0   *Antibodies, Monoclonal Immunosuppression Antigens, CD4. Surgery 1997 Aug;122(2):213-20
OX-38 monoclonal antibody  0   *Antibodies, Monoclonal Antigens, CD4. Surgery 1997 Aug;122(2):213-20
CD4 (81-92)  126144-46-5   *Peptide Fragments *Antigens, CD4 Oligopeptides. Biochim Biophys Acta 1994 Apr 13;1205(2):262-7
CD4 S1 peptide  0   *Peptide Fragments *Antigens, CD4. Vaccine 1993;11(6):682-6
OKT4A monoclonal antibody  0   *Antibodies, Monoclonal Immunosuppression Antigens, CD4. Transplant Proc 1993 Feb;25(1 Pt 1):784-5
recombinant soluble CD4  0   *Antigens, CD4 Recombinant Proteins.
Pharma Action Anti-HIV Agents 		Toxicol Pathol 1991;19(4 Pt 2):580-8
CD4-ricin A chain conjugate  0   *Ricin *Antigens, CD4 Recombinant Proteins. Bioconj Chem 1990;1(1):24
CD4-IgG1 hinge fusion protein, recombinant  0   *Immunoglobulin gamma-Chains *Recombinant Fusion Proteins *Antigens, CD4 Immunoglobulin G. Arch Virol 1990;111(1-2):29
CD4-Pseudomonas toxin  0   *Exotoxins Recombinant Proteins Immunotoxins Bacterial Proteins Antigens, CD4. Nature 1988;335(6188):369
CD4 (76-94)  123380-67-6   *Peptide Fragments *Antigens, CD4. Science 1988;241(4866):712
S-benzyl-CD4 (83-94) peptide  123380-68-7   *Antigens, Differentiation, T-Lymphocyte *Peptide Fragments Antigens, CD4. Science 1988;241(4866):712
vasoactive intestinal peptide (1-12)  112160-96-0   *Peptide Fragments *Vasoactive Intestinal Peptide Antigens, CD4. Ann N Y Acad Sci 1988;527:574

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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