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Serine Proteinase Inhibitors

More information in Books or onNLM PubMed
Definition: Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.  DF: SERINE PROTEINASE INHIB   
See Also Serpins
Examples Antithrombins; Trypsin Inhibitors 		Other names Serine Proteinase Inhibitors, Exogenous; Serine Proteinase Inhibitors, Endogenous; Serine Proteinase Antagonists; Serine Protease Inhibitors; Serine Endopeptidase Inhibitors; Serine Protease Inhibitors, Exogenous; Serine Protease Inhibitors, Endogenous
Substances having this pharmacologic action: subtilisin inhibitor protein, Streptomyces; tissue-factor-pathway inhibitor 2; purpurogallin; methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone; eglin proteinase inhibitors; urokinase inhibitor; benzamidine; nafamostat; Eco protein, E coli; phenylalanyl-prolyl-arginine-chloromethyl ketone; rosmarinic acid; cholesteryl sulfate; DAPI; 4-(2-aminoethyl)benzenesulfonylfluoride; chymostatin; Secretory Leukocyte Peptidase Inhibitor; Serpin E2; ITIH4 protein, human; 4-aminobenzamidine; Angiotensinogen; alpha-2-Antiplasmin; Gabexate; Plasminogen Activator Inhibitor 1; Plasminogen Activator Inhibitor 2; Protein C Inhibitor; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Serpins; Heparin Cofactor II; Plasminogen Inactivators; alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Aprotinin; Amino Acid Chloromethyl Ketones; inter-alpha-inhibitor; SPINT2 protein, human; SPINK7 protein, human; chymotrypsin inhibitor 2; neuroserpin; SERPIN-B5; DX 9065a; ONO 5046; ICI 200355; tick anticoagulant peptide; L 658758; 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate; lipoprotein-associated coagulation inhibitor; 3,4-dichloroisocoumarin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TIL-1 protein, Ancylostoma duodenale  0   *Helminth Proteins Serine Proteinase Inhibitors. Parasitol Res 2011 Feb;108(2):287-95
Spink9 protein, human  0   *Proteinase Inhibitory Proteins, Secretory Serine Proteinase Inhibitors. PLoS One 2009;4(2):e4372
KAZ1 protein, Drosophila  0   *Drosophila Proteins Serine Proteinase Inhibitors. Eur J Biochem 1999 Nov;266(1):282-92
ASPI-2 protein, Ascaris suum  0   *Insect Proteins Pancreatic Elastase Serine Proteinase Inhibitors. Mol Biochem Parasitol 1999 Jul 30;102(1):79-89
bdellastasin  0   *Insect Proteins Fibrinolysin/antagonists & inhibitors Serine Proteinase Inhibitors. J Mol Biol 1999 Oct 15;293(1):93-106
SPINK5 protein, human  0   *Proteinase Inhibitory Proteins, Secretory Serine Proteinase Inhibitors. J Biol Chem 1999 Jul 30;274(31):21499-502
allyl-6-(acetoxyethyl)-penem-3-carboxylate  0   *Carboxylic Acids *Lactams Serine Proteinase Inhibitors. Nature 1998 Nov 12;396(6707):186-90
tPA stop  0 2,7-bis-(4-amidino-benzylidene)-cycloheptan-1-one dihydrochloride  *Cycloheptanes Tissue Plasminogen Activator/antagonists & inhibitors Serine Proteinase Inhibitors. J Cereb Blood Flow Metab. 2004 Oct;24(10):1153-9; Neuron 1998 Oct;21(4):813-25
Pcsk1n protein, mouse  0   *Nerve Tissue Proteins Serine Proteinase Inhibitors. Neuroendocrinology 1998 Mar;67(3):190-6
GR 133687  0   *Lactones *Triterpenes Thrombin/antagonists & inhibitors Serine Proteinase Inhibitors. Biochemistry 1998 May 12;37(19):6645-57
GR 133686  0   *Lactones *Triterpenes Thrombin/antagonists & inhibitors Serine Proteinase Inhibitors. Biochemistry 1998 May 12;37(19):6645-57
Spin2b protein, rat  0   *Serpins *Nuclear Proteins Serine Proteinase Inhibitors. Eur J Biochem 1995 Aug 1;231(3):620-7
anticoagulant protein, Ancylostoma caninum  0   *Helminth Proteins Serine Proteinase Inhibitors. Proc Natl Acad Sci U S A 1995 Jun 20;92(13):6152-6
SIL8 protein, Streptomyces virginiae  0   *Bacterial Proteins Serine Endopeptidases Serine Proteinase Inhibitors. Eur J Biochem 1994 Dec 1;226(2):627-32

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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