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Complement C3a

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Definition: The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.     
Pharmacological Action Immunologic Factors 		Other names Component 3a, Complement; Complement, C3a; C3a, Complement; Complement Component 3a; Complement 3a; C3a Complement
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
WWGKKYRASKLGCAR peptide  0   *Peptides Complement C3a/agonists. Int Immunopharmacol 2009 Jun;9(6):800-6
leucyl-prolyl-leucyl-prolyl-arginine  0   *Oligopeptides Complement C3a/agonists. Biosci Biotechnol Biochem 2001 May;65(5):1202-5
complement C3a receptor  0   *Receptors, Complement Complement C3a. Eur J Immunol 1996 Aug;26(8):1944-50; Immunol Lett 1993 Oct;38(2):153-8
complement C3a, (57-77)  0   *Peptide Fragments *Complement C3a. Am Rev Respir Dis 1990;141(2):296
complement C3a, (Tyr-70-77)  125753-03-9   *Complement C3a. Prog Clin Biol Res 1989;297:221
complement C3a, des-Arg-(77)  0   *Complement C3a Anaphylatoxins. J Biol Chem 2004;279(6):4051; Proc Natl Acad Sci USA 1985;82(3):886
complement C3a, (70-77)  63555-63-5 L-Arginine, N2-(N-(N-(N-(N-(N-(N-L-alanyl-L-seryl)-L-histidyl)-L-leucyl)glycyl)-L-leucyl)-L-alanyl)  *Complement C3a Anaphylatoxins. J Exp Med 1982;156(3):756
complement C3a, (72-77)  66157-45-7 L-Arginine, N2-(N-(N-(N-(N-L-histidyl-L-leucyl)glycyl)-L-leucyl)-L-alanyl)  *Peptide Fragments *Complement C3a. Blut 1982;45(1):13; J Immunol. 1983;130(3):1345

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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