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Complement C5a

More information in Books or onNLM PubMed
Definition: The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.     
Pharmacological Action Immunologic Factors
Examples Complement C5a, des-Arginine 		Other names Component 5a, Complement; Complement, C5a; C5a, Complement; 5a, Complement Component; Complement Component 5a; Complement 5a; C5a Complement
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AcPhe(ornithine-Pro-cyclohexylamine-Trp-Arg)  0   *Peptides, Cyclic Complement C5a/antagonists & inhibitors. Inflammation 2001 Jun;25(3):171-7
cyclo(acetylphenylalanyl-ornithyl-prolyl-cyclohexylalanyl-tryptophyl-arginyl)  0   *Peptides, Cyclic Receptors, Complement/antagonists & inhibitors Complement C5a/antagonists & inhibitors. J Med Chem 1998 Aug 27;41(18):3417-25
C5aRAD  0   *Complement C5a Recombinant Proteins. J Immunol 1998 Jun 1;160(11):5616-21
CGS 27913  0   Complement C5a Recombinant Proteins. J Immunol 1998 Jun 1;160(11):5616-21
complement C5a, (65-74), Tyr(65)-Phe(67)-Pro(69,71)-Ala(73)  0   *Peptide Fragments *Complement C5a Complement C5a/agonists. J Med Chem 1997 Mar 14;40(6):877-84

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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