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Complement Membrane Attack Complex

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Definition: A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.  DF: COMPLEMENT MAC   
Pharmacological Action Immunologic Factors 		Other names Membrane Attack Complex; Complement Complex C5b-9; Complex, Terminal Complement; Complement Complex, Terminal; Complement Complex C5b 9; C5b 8 poly C9; Terminal Complement Complex; Cytolytic Terminal Complement Complex; C5b-8-poly-C9; C 5b-9; C5b-9
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SC5b-9 protein complex  0   *Complement Membrane Attack Complex. J Immunol Methods 1985;85(2):245
complement C9 polymer  0   *Complement C9 Complement Membrane Attack Complex. J Biol Chem 1984;259(3):1922
S-protein (control)  0   *Membrane Glycoproteins Complement Membrane Attack Complex. J Biol Chem 254(19):9808;1979; J Immunol 1980;124(4):1779

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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