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Integrins

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Definition: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.  prefer specifics   
See Also Cell Adhesion Molecules
Examples Integrin alpha Chains; Integrin beta Chains; Receptors, Cytoadhesin; Receptors, Fibrinogen; Receptors, Fibronectin; Receptors, Leukocyte-Adhesion; Receptors, Very Late Antigen; Receptors, Vitronectin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
integrin alpha 9, human  0   *Integrins. Clin Cancer Res 2009 Feb 1;15(3):762-9
integrin alphaupsilonbeta6  0   *Integrins Colonic Neoplasms Tumor Markers, Biological. Int J Cancer 2008 Sep 15;123(6):1311-7
Ina-1 protein, C elegans  0   *Integrins *Caenorhabditis elegans Proteins. Genes Dev 2007 Jul 1;21(13):1615-20
lebectin protein, Macrovipera lebetina  0   *Viper Venoms *Lectins, C-Type Integrins Angiogenesis Inhibitors. J Cell Physiol 2007 May;211(2):307-15
integrin alpha11beta1  0   *Integrins *Receptors, Collagen. Dev Biol 2001 Sep 1;237(1):116-29
alpha 6p integrin  0   *Antigens, Surface Integrins. Cell Growth Differ 2002 Mar;13(3):107-13
polylysine-molossin peptide  0   *Carrier Proteins *Crotalid Venoms *Peptide Fragments Integrins. J Gene Med 2001 Nov-Dec;3(6):560-8
ond(a) antigen  0   *Isoantigens Integrins. Blood 1996 Aug 15;88(4):1350-8
LDP-02 monoclonal antibody  0   *Antibodies, Monoclonal Integrins. Curr Opin Investig Drugs 2001 Apr;2(4):502-4
molossin peptide  0   *Oligopeptides Crotalid Venoms Integrins. Transplantation 2000 Dec 15;70(11):1616-24
penicillamyl-glycyl-arginyl-glycyl-aspartyl-seryl-prolyl-cysteinyl-alanine  0   *Oligopeptides *Peptides, Cyclic Integrins/antagonists & inhibitors. Circ Res 1998 Aug 10;83(3):241-51
VCAM345 peptide  0   *Peptides, Cyclic Integrins/antagonists & inhibitors. Thromb Res 2000 Jan 15;97(2):39-50
integrin alphavbeta8  0   *Integrins. J Cell Sci 1999 Dec;112 ( Pt 23):4271-9
TAP20 protein, rat  0   *Membrane Glycoproteins Integrins. J Cell Biol 1999 Nov 29;147(5):1073-83
SM 256  0   *Indazoles *Sulfonamides Integrins/antagonists & inhibitors. J Cardiovasc Pharmacol 1999 Apr;33(4):641-6
At14a protein, Arabidopsis  0   *Arabidopsis Proteins Integrins. Gene 1999 Apr 1;230(1):33-40
alpha-SU2 protein, Lytechinus variegatus  0   *Integrins Sea Urchins. Dev Biol 1999 Mar 1;207(1):1-13
BIO 1211  0   *Oligopeptides Integrins/antagonists & inhibitors. J Med Chem 1999 Mar 11;42(5):920-34
EMD 121974  0   *Peptides, Cyclic Integrins/antagonists & inhibitors. Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1591-6
integrin alpha 9 beta 1  0   *Integrins. FEBS Lett 1998 Jun 16;429(3):269-73
integrin alpha8beta1  0   *Integrins Receptors, Fibronectin. Mol Biol Cell 1995 Apr;6(4):433-48
integrin alpha7beta1  0   *Integrins Receptors, Laminin. J Biol Chem 1993 Sep 5;268(25):19019-24
integrin, leukocyte response  0   *Integrins. J Biol Chem 1992 Jul 15;267(20):13895-902
integrin alphavbeta6  0   *Antigens, Neoplasm *Integrins Receptors, Virus. J Biol Chem 1992 Mar 25;267(9):5790-6
integrin alpha4beta7  0   *Integrins. J Cell Biol 1991 Nov;115(4):1149-58
integrin alphaEbeta7  0   *Integrins Antigens, Neoplasm Tumor Markers, Biological. Histopathology 1991;18(5):421
Tn receptor  0   *Receptors, Antigen Antigens Integrins. Rev Fr Transfus Immunohematol 1980;23(5):613

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