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Genes, Tumor Suppressor

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Definition: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.  Manual 24.4.4.3   
See Also Tumor Suppressor Proteins
Examples Genes, APC; Genes, BRCA1; Genes, BRCA2; Genes, DCC; Genes, MCC; Genes, Neurofibromatosis 1; Genes, Neurofibromatosis 2; Genes, p16; Genes, p53; Genes, Retinoblastoma; Genes, Wilms Tumor 		Other names Tumor Suppressor Genes; Metastasis Suppressor Genes; Growth Suppressor Genes; Genes, Metastasis Suppressor; Genes, Growth Suppressor; Genes, Cancer Suppressor; Emerogenes; Cancer Suppressor Genes; Antioncogenes; Tumor Suppressor Gene; Tumor Suppressing Gene; Suppressor Genes, Metastasis; Suppressor Genes, Growth; Suppressor Genes, Cancer; Suppressor Gene, Metastasis; Suppressor Gene, Growth; Suppressor Gene, Cancer; Recessive Oncogenes; Recessive Oncogene; Oncogene, Recessive
 
SubstanceCAS Registry & nameCategoriesSource
l(3)mbt protein, Drosophila  0   *Drosophila Proteins Genes, Tumor Suppressor. Science. 2010 Dec 24;330(6012):1824-7
NRSN2 protein, human  0   *Membrane Proteins Genes, Tumor Suppressor. World J Gastroenterol. 2009 Oct 14;15(38):4844-8
RASEF protein, human  0   *ras Guanine Nucleotide Exchange Factors Genes, Tumor Suppressor. Invest Ophthalmol Vis Sci 2008 Apr;49(4):1291-8
RERG protein, human  EC 3.6.1.-.   *GTP Phosphohydrolases Genes, Tumor Suppressor. Methods Enzymol 2006;407():(513-27
RPS14 protein, human  0   *Ribosomal Proteins Genes, Tumor Suppressor. Nature 2008 Jan 17;451(7176):252-3
CYLD protein, Drosophila  0   *Tumor Suppressor Proteins *Drosophila Proteins Genes, Tumor Suppressor. Development 2007 Jul;134(14):2605-14
DLG1 protein, human  0   *Membrane Proteins *Adaptor Proteins, Signal Transducing Genes, Tumor Suppressor.
Dlgh1 protein, mouse  EC 2.7.4.8   *Membrane Proteins *Guanylate Kinase Genes, Tumor Suppressor Adaptor Proteins, Signal Transducing.
FAT1 protein, human  0   *Cadherins Genes, Tumor Suppressor.
HIC1 protein, zebrafish  0   *Zebrafish Proteins *Kruppel-Like Transcription Factors Genes, Tumor Suppressor Zinc Fingers. Biochim Biophys Acta 2004 Apr 16;1678(1):57-66
Plagl1 protein, mouse  0   *Transcription Factors *Genes, Tumor Suppressor *Cell Cycle Proteins.
Plagl1 protein, rat  0   *Transcription Factors *Genes, Tumor Suppressor *Cell Cycle Proteins.
BECN1 protein, human  0   *Membrane Proteins *Apoptosis Regulatory Proteins Genes, Tumor Suppressor.
Kiss1 protein, rat  0   *Kisspeptins Genes, Tumor Suppressor.
NKX3-1 protein, human  0   *Transcription Factors *Homeodomain Proteins Genes, Tumor Suppressor.
Tob1 protein, mouse  0   *Carrier Proteins Genes, Tumor Suppressor.
Madh4 protein, rat  0   *Smad4 Protein Signal Transduction Genes, Tumor Suppressor Transforming Growth Factor beta.
Smad4 protein, mouse  0   *Smad4 Protein Signal Transduction Genes, Tumor Suppressor Transforming Growth Factor beta.
Lats1 protein, mouse  EC 2.7.1.-   *Protein-Serine-Threonine Kinases Apoptosis Genes, Tumor Suppressor.
Nbl1 protein, mouse  0   *Proteins Genes, Tumor Suppressor.
NBL1 protein, human  0   *Proteins Genes, Tumor Suppressor.
IFRD1 protein, human  0   *Immediate-Early Proteins Genes, Tumor Suppressor.
Ifrd1 protein, mouse  0   *Membrane Proteins *Immediate-Early Proteins Genes, Tumor Suppressor.
tp73l protein, zebrafish  0   *Phosphoproteins *Trans-Activators *Zebrafish Proteins Genes, Tumor Suppressor. Dev Cell. 2002 May;2(5):607-16
tp73l protein, Xenopus  0   *Phosphoproteins *Trans-Activators *Xenopus Proteins Genes, Tumor Suppressor. Mech Dev. 2001 Apr;102(1-2):275-8
PYHIN1 protein, human  0   *Nuclear Proteins Genes, Tumor Suppressor. Oncogene 2004 Jun 3;23(26):4556-66
Trp63 protein, mouse  0   *Phosphoproteins *Trans-Activators Genes, Tumor Suppressor.
Doc-1r protein, mouse  0   *Oncogene Proteins *Genes, Tumor Suppressor.
Men1 protein, mouse  0   *Proto-Oncogene Proteins Genes, Tumor Suppressor Multiple Endocrine Neoplasia Type 1. Mol Endocrinol. 2003 Sep;17(9)1880-92
CHTF8 protein, human  0   *Genes, Tumor Suppressor. Mol Med 2002 Oct;8(10):655-63
OSCP1 protein, human  0   *Membrane Transport Proteins Nasopharyngeal Neoplasms Genes, Tumor Suppressor. J Cancer Res Clin Oncol 2003 Jul;129(7);410-4
SSBP2 protein, human  0   *DNA-Binding Proteins Genes, Tumor Suppressor. Genomics 2002 Jul;80(1):78-85
HOP protein, human  0   *Homeodomain Proteins *Tumor Suppressor Proteins Genes, Tumor Suppressor. Genomics 2003 Jan;81(1):15-25
SLC5A8 protein, human  0   *Cation Transport Proteins Genes, Tumor Suppressor. J Clin Endocrinol Metab 2002 Jul;87(7):3500-3; Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8412-7
ING3 protein, human  0   *Genes, Tumor Suppressor *Homeodomain Proteins. Oncogene 2002 Jun 27;21(28):4462-70
Rassf3 protein, mouse  0   *Monomeric GTP-Binding Proteins Genes, Tumor Suppressor. Oncogene 2002 Apr 18;21(17):2713-20
RASSF5 protein, human  0   *Monomeric GTP-Binding Proteins Genes, Tumor Suppressor Apoptosis. Oncogene 2002 Apr 18;21(17):2713-20
RASSF3 protein, human  0   *Monomeric GTP-Binding Proteins Genes, Tumor Suppressor. Oncogene 2002 Apr 18;21(17):2713-20
RARRES1 protein, human  0   *Membrane Proteins Prostatic Neoplasms Genes, Tumor Suppressor. J Natl Cancer Inst 2002 Apr 3;94(7):482-90
btg2 protein, zebrafish  0   *Carrier Proteins *Zebrafish Proteins Genes, Tumor Suppressor. Mech Dev 2001 Jun;104(1-2):113-5
MRO protein, human  0   *Neoplasm Proteins Genes, Tumor Suppressor. Genomics 2001 Mar 1;72(2):169-79
SEZ6L protein, human  0   *Membrane Proteins Signal Transduction Genes, Tumor Suppressor. Oncogene 2000 Dec 14;19(54):6251-60
PERP protein, human  0   *Membrane Proteins *Genes, Tumor Suppressor. Anticancer Res 2000 Sep-Oct;20(5A):2801-10
brat protein, Drosophila  0   *DNA-Binding Proteins *Drosophila Proteins Genes, Tumor Suppressor Zinc Fingers. Oncogene 2000 Aug 3;19(33):3706-16
CYLD protein, human  0   *Tumor Suppressor Proteins Genes, Tumor Suppressor. Nat Genet 2000 Jun;25(2):160-5
FAM107A protein, human  0   *Nuclear Proteins *Genes, Tumor Suppressor. Genes Chromosomes Cancer 2000 Jan;27(1):1-10
DOC-1R protein, human  0   *Oncogene Proteins *Genes, Tumor Suppressor. Biochem Biophys Res Commun 1999 Feb 5;255(1):59-63
TSSC4 protein, human  0   *Tumor Suppressor Proteins Genes, Tumor Suppressor. Hum Mol Genet 1999 Apr;8(4):683-90
DIRAS3 protein, human  0   *rho GTP-Binding Proteins Genes, Tumor Suppressor. Proc Natl Acad Sci U S A 1999 Jan 5;96(1):214-9
Becn1 protein, mouse  0   *Apoptosis Regulatory Proteins Autophagy Genes, Tumor Suppressor. J Virol 1998 Nov;72(11):8586-96
C3orf51 protein, human  0   *Proteins Genes, Tumor Suppressor Tumor Suppressor Proteins. Genomics 1998 Jun 1;50(2):187-98
DBC1 protein, human  0   *Tumor Suppressor Proteins Genes, Tumor Suppressor. Genomics 1998 Mar 15;48(3):277-88
TSSC2 protein, human  0   *Nuclear Proteins Genes, Tumor Suppressor. Genomics 1997 Nov 15;46(1):9-17
TSSC1 protein, human  0   *Nuclear Proteins Genes, Tumor Suppressor. Genomics 1997 Nov 15;46(1):9-17
TSSC3 protein  0   *Nuclear Proteins Placenta Liver Genes, Tumor Suppressor Genomic Imprinting. Genomics 1997 Nov 15;46(1):9-17; Hum Mol Genet 1997 Nov;6(12):2021-9
tuberous sclerosis complex 1 protein  0   *Tumor Suppressor Proteins Genes, Tumor Suppressor. Science 1997 Aug 8;277(5327):805-8
KISS1 protein, human  0   *Kisspeptins Genes, Tumor Suppressor. Cancer Res 1997 Jun 15;57(12):2384-7
MEN1 protein, human  0   *Proto-Oncogene Proteins Genes, Tumor Suppressor Multiple Endocrine Neoplasia Type 1. Science 1997 Apr 18;276(5311):404-7
Nkx3-1 protein, mouse  0   *Transcription Factors *Homeodomain Proteins Genes, Tumor Suppressor. J Biol Chem 1996 Dec 13;271(50):31779-82
WT1 protein, Xenopus  0   *DNA-Binding Proteins *WT1 Proteins *Xenopus Proteins Genes, Tumor Suppressor Zinc Fingers. Gene 1996 Oct 10;175(1-2):167-72
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