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Cytokines

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Definition: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.     
Examples Chemokines; Growth Differentiation Factor 15; Hematopoietic Cell Growth Factors; Hepatocyte Growth Factor; Interferons; Interleukin 1 Receptor Antagonist Protein; Interleukins; Leukemia Inhibitory Factor; Lymphokines; Monokines; Oncostatin M; Osteopontin; Transforming Growth Factor beta; Tumor Necrosis Factors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MEDA-7 protein, mouse  0   *Cytokines. Diabetologia. 2011 Sep;54(9):2368-80
MEDA-7 protein, human  0   *Cytokines Obesity. Diabetologia. 2011 Sep;54(9):2368-80
C1qTNF-related protein 4, human  0   *Cytokines. Cancer Lett 2011 Sep 28;308(2):203-14
Gpi protein, rat  EC 5.3.1.9   *Glucose-6-Phosphate Isomerase Cytokines.
Gpi1 protein, mouse  EC 5.3.1.9   *Glucose-6-Phosphate Isomerase Cytokines.
GPI protein, human  EC 5.3.1.9   *Glucose-6-Phosphate Isomerase Cytokines.
FAM3D protein, human  0   *Cytokines. Hum Genet. 2010 Oct;128(4):433-41
GIFT12 protein  0   *Recombinant Fusion Proteins *Cytokines. Med Sci (Paris). 2010 Feb;26(2):137-9
SOFAT protein, human  0   *Cytokines. Arthritis Rheum. 2009 Nov;60(11):3324-35
metron factor-1  0   *Recombinant Fusion Proteins *Cytokines. Nat Biotechnol 2002 May;20(5):488-95
GIFT15 protein  0   *Recombinant Fusion Proteins *Cytokines. Blood 2007 Mar 1;109(5):2234-42
Aimp1 protein, mouse  0   *Cytokines. Proc Natl Acad Sci U S A 2006 Oct 3;103(40):14913-8
Miple2 protein, Drosophila  0   *Cytokines *Drosophila Proteins. Dev Genes Evol 2006 Jan;216(1):10-8
Miple1 protein, Drosophila  0   *Cytokines *Drosophila Proteins. Dev Genes Evol 2006 Jan;216(1):10-8
CER1 protein, human  0   *Cytokines. Genes Chromosomes Cancer 1997 Dec;20(4):329-36
FAM3C protein, human  0   *Neoplasm Proteins *Cytokines. Cancer Cell 2006 Sep;10(3):227-39
interferon-lambda protein, mouse  0   *Cytokines. J Immunol 2006 Jun 15;176(12):7686-94
Mcr protein, Drosophila  0   *Serpins *Cytokines. PLoS Biol 2006 Jan;4(1):e4
Ins-33 protein, C elegans  0   *Cytokines *Caenorhabditis elegans Proteins. Mol Cell Biol 2005 Dec;25(24):11059-72
nicotinamide phosphoribosyltransferase, rat  EC 2.4.2.12   *Cytokines *Nicotinamide Phosphoribosyltransferase. Biochem Biophys Res Commun 2005 Oct 28;336(3):747-53
PANDER protein, mouse  0   *Cytokines Apoptosis. Am J Physiol Endocrinol Metab 2005 Oct;289(4):E543-50
DOC1 protein, human  0   *Cytokines. Cytokine. 2005 Jun 21;30(6):347-58
astakine protein, Penaeus monodon  0   *Vascular Endothelial Growth Factor, Endocrine-Gland-Derived Cytokines. J Immunol. 2005 May 15;174(10):6153-60
astakine protein, Pacifastacus leniusculus  0   *Vascular Endothelial Growth Factor, Endocrine-Gland-Derived Cytokines. J Immunol. 2005 May 15;174(10):6153-60
INGAP peptide  0   *Peptide Fragments *Cytokines. FASEB J 2004 Nov;18(14):1767-9
nicotinamide phosphoribosyltransferase, mouse  EC 2.4.2.12   *Cytokines *Nicotinamide Phosphoribosyltransferase. Science 2005 Jan 21;307(5708):366-7
PGLYRP1 protein, human  0   *Cytokines.
Pglyrp protein, rat  0   *Cytokines.
Ccl2 protein, mouse  0   *Chemokine CCL2 Autoantigens Cytokines.
Ccl2 protein, rat  0   *Chemokine CCL2 Autoantigens Cytokines.
G1p2 protein, mouse  0   *Cytokines Ubiquitins Carrier Proteins.
Fam3c protein, mouse  0   *Neoplasm Proteins *Cytokines. Gene 2004 Jun 23;335:159-68
Ik protein, mouse  0   *Cytokines Histocompatibility Antigens Class II.
novel neurotrophin-1, mouse  0   *Cytokines. Proc Natl Acad Sci U S A 1999 Sep 28;96(20):11458-63
regeneration and tolerance factor  0   *Suppressor Factors, Immunologic Cytokines. Clin Diagn Lab Immunol 1999 Mar;6(2):193; Hum Immunol 2001 Jun;62(6):577
methyl 5-(8-acetoxy-7-hydroxypropyl)pyridine-2-carboxylate  0   *Picolinic Acids Cytokines/antagonists & inhibitors. J Antibiot (Tokyo) 2001 Sep;54(9):703-9
methyl 5-(7,8-dihydroxypropyl)pyridine-2-carboxylate  0   *Picolinic Acids Cytokines/antagonists & inhibitors. J Antibiot (Tokyo) 2001 Sep;54(9):703-9
MIF protein, Amblyomma americanum  0   *Cytokines *Arthropod Proteins. Insect Mol Biol 2001 Aug;10(4):323-31
SCGB3A1 protein, human  0   *Cytokines *Tumor Suppressor Proteins. Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9796-801
ITLN1 protein, human  0   *Cytokines *Lectins GPI-Linked Proteins. J Biol Chem 2001 Jun 29;276(26):23456-63
Il24 protein, mouse  0   *Cytokines. J Immunol 2001 May 15;166(10):5859-63
Prlpe protein, mouse  0   *Cytokines *Pregnancy Proteins. Endocrinology 1997 Dec;138(12):5535-40
IL24 protein, rat  0   *Cytokines. J Biol Chem 2000 Aug 11;275(32):24436-43
C17 protein, human  0   *Blood Proteins *Cytokines. Genomics 2000 May 1;65(3):283-92
limitin  0   *Cytokines Interferons. Nat Med 2000 Jun;6(6):659-66
IL-10-related T cell-derived inducible factor, IL-TIF  0   *Cytokines Interleukin-10 Interleukin-9. J Immunol 2000 Feb 15;164(4):1814-9
cardiotrophin-like cytokine  0   *Cytokines. Biochem Biophys Res Commun 1999 Aug 19;262(1):132-8
thymic stromal lymphopoietin  0   *Cytokines Thymus Gland Interleukin-7 Stromal Cells. J Immunol 1999 Jan 15;162(2):677-83
IRX 2  0   *Cytokines. Int J Immunopharmacol 1997 Nov-Dec;19(11-12):619-27
resuscitation-promoting factor, bacteria  0   *Bacterial Proteins *Cytokines. Proc Natl Acad Sci U S A 1998 Jul 21;95(15):8916-21
Pglyrp1 protein, mouse  0   *Cytokines. J Biol Chem 1998 Jul 17;273(29):18633-9
haptotaxin  0   *Cytokines. Anticancer Res 1998 May-Jun;18(3A):1601-12
TRANK protein, human  0   *Cytokines. J Immunol 1998 Jul 1;161(1):1-6
FR 143430  0   *Pyrazoles *Pyrimidines Cytokines/antagonists & inhibitors. Anticancer Res 1998 Jan-Feb;18(1A):139-44
polypeptide 48  0   *Membrane Proteins *Cytokines. Immunology 1995 Nov;86(3):463-8
CNI 1493  0   *Hydrazones Cytokines/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Immunosuppressive Agents 		Mol Med 1995 Mar;1(3):254-66
cytokine inducible SH2-containing protein  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction Cytokines src Homology Domains. EMBO J 1995 Jun 15;14(12):2816-26
CGP 47969A  0   *Piperazines Interleukin-1/antagonists & inhibitors Cytokines/antagonists & inhibitors Tumor Necrosis Factor-alpha/antagonists & inhibitors Interleukin-6/antagonists & inhibitors. J Rheumatol 1994 Nov;21(11):1992-7
cardiotrophin 1  0   *Cytokines. Proc Natl Acad Sci U S A 1995 Feb 14;92(4):1142-6
endothelial neutrophil activating peptide  0   *Interleukin-8 Cytokines. Am J Pathol 1994 Dec;145(6):1382-9
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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