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Transforming Growth Factor beta

More information in Books or onNLM PubMed
Definition: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.     
Examples Transforming Growth Factor beta1; Transforming Growth Factor beta2; Transforming Growth Factor beta3 		Other names TGF-beta; Platelet Transforming Growth Factor; Bone-Derived Transforming Growth Factor; Growth Factor, Milk; Factor, Milk Growth; Bone Derived Transforming Growth Factor; TGFbeta; Milk Growth Factor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
gonadal soma-derived factor, zebrafish  0   *Transforming Growth Factor beta *Zebrafish Proteins. Biol Reprod. 2011 Dec;85(6):1240-51
ADMP2 protein, Xenopus  0   *Transforming Growth Factor beta *Xenopus Proteins. Dev Biol 2006 Nov 15;299(2):411-23
sara protein, Drosophila  0   *Transforming Growth Factor beta *Drosophila Proteins. Science. 2006 Nov 17;314(5802):1094-6
Vg1 protein, Xenopus  0   *Transforming Growth Factor beta *Xenopus Proteins.
Gdf7 protein, mouse  0   *Bone Morphogenetic Proteins *Growth Differentiation Factors Transforming Growth Factor beta.
recombinant human bone morphogenetic protein-2  0   *Transforming Growth Factor beta *Bone Morphogenetic Protein 2 Recombinant Proteins.
cartilage-derived morphogenetic protein-3 protein, mouse  0   *Bone Morphogenetic Proteins Transforming Growth Factor beta. J Cell Physiol. 2004 Dec;201(3):401-8
Gdf11 protein, rat  0   *Growth Differentiation Factors Transforming Growth Factor beta.
SMAD8 protein, human  0   *Smad8 Protein Signal Transduction Transforming Growth Factor beta.
Smad8 protein, Xenopus  0   *Xenopus Proteins *Smad8 Protein Signal Transduction Transforming Growth Factor beta.
Smad9 protein, mouse  0   *Smad8 Protein Signal Transduction Transforming Growth Factor beta.
Madh4 protein, rat  0   *Smad4 Protein Signal Transduction Genes, Tumor Suppressor Transforming Growth Factor beta.
Smad4 protein, mouse  0   *Smad4 Protein Signal Transduction Genes, Tumor Suppressor Transforming Growth Factor beta.
Ndr2 protein, Xenopus  0   *Xenopus Proteins Transforming Growth Factor beta. Development 1995 Nov;121(11):3651-62
ndr1 protein, zebrafish  0   *Zebrafish Proteins *Nodal Signaling Ligands Transforming Growth Factor beta. Nature 1998 Sep 10;395(6698):181-5
latency-associated propeptide, TGF-beta  0   *Peptides *Protein Precursors *Transforming Growth Factor beta Protein Sorting Signals. Connect Tissue Res 2002;43(2-3):381-6
transforming growth factor beta4  0   *Transforming Growth Factor beta. Vaccine 2001 Oct 12;20(1-2):267-74
As60A protein, Anopheles stephensi  0   *Transforming Growth Factor beta *Insect Proteins. Cytokine 2001 Jan 21;65-74
maverick protein, Drosophila  0   *Drosophila Proteins Transforming Growth Factor beta. Blood 2000 Oct 15;96(8):201-6
transforming growth factor beta2.3  0   *Transforming Growth Factor beta.
transforming growth factor beta1.2  0   *Transforming Growth Factor beta.
TGF-beta5 protein, Xenopus laevis  0   *Transforming Growth Factor beta *Xenopus Proteins.
DAF-14 protein, C elegans  0   *Caenorhabditis elegans Proteins *Smad Proteins Signal Transduction Transforming Growth Factor beta. Dev Biol 2000 Jan 1;217(1):192-204
myoglianin protein, Drosophila  0   *Transforming Growth Factor beta *Drosophila Proteins. Mech Dev 1999 Aug;86(1-2):171-5
derriere protein, Xenopus  0   *Xenopus Proteins *Intercellular Signaling Peptides and Proteins Transforming Growth Factor beta. Development 1999 Apr;126(7):1467-82
Dbl-1 protein, C elegans  0   *Neuropeptides *Transforming Growth Factor beta *Caenorhabditis elegans Proteins. Development 1999 Jan;126(2):241-50; Development 1999 Mar;126(6):1337-47
Ndr2 protein, vertebrate  0   *Proteins Transforming Growth Factor beta. Dev Biol 1998 Jul 15;199(2):261-72
UNC-129 protein, C elegans  0   *Transforming Growth Factor beta *Caenorhabditis elegans Proteins. Science 1998 Jul 31;281(5377):706-9
Medea protein, Drosophila  0   *Drosophila Proteins *Smad4 Protein Signal Transduction Transforming Growth Factor beta. Development 1998 Apr;125(8):1407-20
CKS 25  0   *Peptides Transforming Growth Factor beta. J Biol Chem 1998 Feb 27;273(9):4815-8
Madh9 protein, rat  0   *Smad8 Protein Signal Transduction Transforming Growth Factor beta. Proc Natl Acad Sci U S A 1997 Nov 25;94(24):12938-43
DAF-3 protein, C elegans  0   *Caenorhabditis elegans Proteins *Smad Proteins Signal Transduction Transforming Growth Factor beta. Genes Dev 1997 Oct 15;11(20):2679-90
XNR4 protein, Xenopus  0   *Xenopus Proteins *Transforming Growth Factor beta Xenopus. Dev Biol 1997 Apr 15;184(2):367-72
DAF-7 protein, C elegans  0   *Transforming Growth Factor beta *Caenorhabditis elegans Proteins. Science 1996 Nov 22;274(5291):1389-91
fugacin  0   *Transforming Growth Factor beta. Dev Biol 1995 Dec;172(2):699-703
Xnr3 protein, Xenopus  0   *Transforming Growth Factor beta *Xenopus Proteins Xenopus. Cell 1995 Jul 14;82(1):37-46
univin  0   *Transforming Growth Factor beta. Dev Biol 1994 Nov;166(1):149-58
screw protein, Drosophila  0   *Transforming Growth Factor beta *Drosophila Proteins. Genes Dev 1994 Nov 1;8(21):2588-601
cartilage-derived-morphogenetic protein-2  0   *Bone Morphogenetic Proteins Transforming Growth Factor beta. J Biol Chem 1994 Nov 11;269(45):28227-34
gbb protein, Drosophila  0   *Transforming Growth Factor beta *Drosophila Proteins. Cell Growth Differ 1994 Jun;5(6):585-93
growth differentiation factor 7  0   *Bone Morphogenetic Proteins Transforming Growth Factor beta. Nature 1994 Apr 14;368(6472):639-43
transforming growth factor-beta type II receptor  EC 2.7.11.30   *Protein-Serine-Threonine Kinases *Receptors, Transforming Growth Factor beta Transforming Growth Factor beta. Biochem Biophys Res Commun 1993 Mar 31;191(3):790-5
dvr1 protein, zebrafish  0   *Transforming Growth Factor beta *Zebrafish Proteins. Development 1989 Aug;106(4):775-85
betaIG-H3 protein  148710-76-3   *Transforming Growth Factor beta *Extracellular Matrix Proteins Zebrafish Proteins. DNA Cell Biol 1992 Sep;11(7):511-22
dpp protein, Drosophila  0   *Drosophila Proteins Transforming Growth Factor beta. Mol Cell Biol 1990;10(6):2669

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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