Mutagenesis (definition)

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Mutagenesis, Insertional

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Definition: Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

See Also DNA Transposable Elements

Other names Viral Insertional Mutagenesis; Sequence Insertion; Mutagenesis, Cassette; Linker-Insertion Mutagenesis; Insertional Mutagenesis; Insertional Activation; Insertion Mutation; Gene Insertion; Sequence Insertions; Mutations, Insertion; Mutation, Insertion; Mutagenesis, Viral Insertional; Mutagenesis, Linker-Insertion; Linker Insertion Mutagenesis; Insertions, Sequence; Insertions, Gene; Insertional Mutagenesis, Viral; Insertional Activations; Insertion, Sequence; Insertion, Gene

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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