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Enkephalin, Leucine-2-Alanine

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Definition: A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.  DF: DADLE    Other names Leucine Enkephalin-2-Alanine; Enkephalin-Leu,Ala(2); D-Ala(2)-D-Leu(5)-Enkephalin; 5-Leucine-2-Alanine Enkephalin; 2-Alanyl-Leucine Enkephalin; Leucine-2-Alanine Enkephalin; Leucine Enkephalin 2 Alanine; Leu Enkephalin 2 Ala; Enkephalin-2-Alanine, Leucine; Enkephalin, Leucine 2 Alanine; Enkephalin, 5-Leucine-2-Alanine; Enkephalin, 2-Alanyl-Leucine; BW180C; BW 180C; 5 Leucine 2 Alanine Enkephalin; 2 Alanyl Leucine Enkephalin; Leu-Enkephalin-2-Ala; DADLE; BW-180C
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
dalargin, destyrosyl  0   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Bull Exp Biol Med 2004 Jan;137(1):27-30
enkephalin-Leu-polyethylene glycol, Ala(2)  0   *Polyethylene Glycols Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Biol Pharm Bull 1994 Jun;17(6):823-5
enkephalin-Leu, Ala(2)-Ser(6)  132930-82-6   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Eur J Pharmacol 1991;192(3):371
enkephalin-Leu methyl ester, Ala(2)-cyclopropyl-Phe(4)  117783-82-1   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Eur J Pharmacol 1990;177(1-2)99
enkephalin-Leu, (Ala(2)-Cl-Phe(4))  77062-77-2   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Int J Pept Protein Res 1987;30(4):489
enkephalin-Leu, Ala(2)-(cyclopropyl-Phe)(4)  88466-08-4   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. FEBS Lett 1987;222(1):71
enkephalin-Leu, Ala(2)-Cys(6)  110881-59-9   Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Pharma Action Affinity Labels 		J Biol Chem 1987;262(28):13434
enkephalin-Leu, Ala(2)-cystamine-dimer  99043-48-8   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Int J Pept Protein Res 1986;27(2):153
tyrosyl-alanyl-glycyl-phenylalanyl-psi(thiomethylene)leucine  103834-43-1   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Biochem Biophys Res Commun 1986;136(2):730
enkephalin-Leu, N,N-diallyl-Ala(2)-bis(cystine)(6)  93450-55-6   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Jpn J Pharmacol 1984;36(4):485
enkephalin-Leu, N,N-diallyl-Ala(2)  88285-66-9   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Jpn J Pharmacol 1984;36(4):485
enkephalinamide-Leu, Ala(2)-N-(2-((4-azido-2-nitrophenyl)amino)N-ethyl(5))  83544-71-2 L-Leucinamide, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-N-(2-((4-azido-2-nitrophenyl)amino)ethyl)-, (2S-(1(R*(R*)),2R*))  *Azides Enkephalin, Leucine-2-Alanine/*analogs & derivatives. J Med Chem 1984;27(7):836
enkephalin-Leu, Ala(2)-Me-Phe(4)  64963-13-9 L-Leucine, N-(N-(N-methyl-N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-, (3S-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))  Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Life Sci 1984;34(21):2015
enkephalin-Leu, Ala(2)-Arg(6)  81733-79-1   Enkephalin, Leucine-2-Alanine/*analogs & derivatives Nerve Growth Factors.
Pharma Action Adjuvants, Immunologic ; Analgesics ; Anti-Arrhythmia Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Anti-Ulcer Agents ; Antioxidants ; Gastrointestinal Agents ; Sympatholytics 		Biull Eksp Biol Med 184;97(3):261
enkephalin-Leu, Ala(2)-melphalan methyl ester  88457-22-1 L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-(N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)-, methyl ester  Melphalan/*analogs & derivatives Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Life Sci 1983;33 suppl 1:435
enkephalinamide-Leu, Ala(2)-aminoethyl dimer  82221-89-4   Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Life Sci 1982;31(15):1625
enkephalinamide-Leu, de-Tyr(1)-Ala(2)  84145-88-0 L-Leucinamide, D-alanylglycyl-L-phenylalanyl  Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Biochem Pharmacol 1982;31(16):2699
enkephalinamide-Leu, Ala(2)  65189-64-2 L-leucinamide, L-tyrosyl-D-alanylglycyl-L-phenylalanyl  Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Neurochem Res 1981;6(3):321
azoenkephalin  76995-89-6 L-Leucine, glycylglycyl-4-((5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl)azo)-L-phenylalanyl-, cyclic (3-1)-peptide  Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Mol Cell Biochem 1981;34(1):23
2-Ala-5-N-Et-Leu-enkephalinamide  67787-85-3 L-tyrosyl-D-alanylglycyl-L-phenylalanyl-N-ethyl-D-leucinamide  Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Br J Pharmacol 1980;68(1):159P

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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