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Extracellular Matrix Proteins

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Definition: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).  /drug eff /ultrastruct permitted   
See Also Receptors, Cytoadhesin
Examples Activated-Leukocyte Cell Adhesion Molecule; Aggrecans; CCN Intercellular Signaling Proteins; Collagen; Elastin; Fibronectins; Integrin-Binding Sialoprotein; Laminin; Osteopontin; Tenascin; Versicans; Vitronectin 		Other names Proteins, Extracellular Matrix; Matrix Proteins, Extracellular
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TINag protein, rat  0   *Extracellular Matrix Proteins Nephritis, Interstitial. J Am Soc Nephrol. 2009 Apr;20(4):807-19.
Magu protein, Drosophila  0   *Extracellular Matrix Proteins *Drosophila Proteins. Mol Genet Genomics 2009 Feb;281(2):147-62
CRELD2 protein, mouse  0   *Cell Adhesion Molecules *Extracellular Matrix Proteins Epidermal Growth Factor. FEBS Lett. 2011 Aug 4;585(15):2481-7
Podnl protein, mouse  0   *Extracellular Matrix Proteins. Biochem Biophys Res Commun 2011 Jul 1;410(2):333-8
Frac protein, Drosophila  0   *Extracellular Matrix Proteins *Drosophila Proteins. J Neurosci 2011 Apr 6;31(14):5335-47
HAPLN3 protein, human  0   *Proteoglycans *Extracellular Matrix Proteins. J Biol Chem 2003 Jun 6;278(23):21083-91
F-spondin protein, mouse  0   *Extracellular Matrix Proteins. J Orthop Res 2010 Oct;28(10):1323-9
hemicentin1 protein, zebrafish  0   *Extracellular Matrix Proteins *Zebrafish Proteins. PLoS Genet 2010;6(4):e1000907
AMACO protein, zebrafish  0   *Extracellular Matrix Proteins *Zebrafish Proteins. Gene Expr Patterns 2010 Jan;10(1):53-9
F-spondin protein, C elegans  0   *Extracellular Matrix Proteins *Caenorhabditis elegans Proteins. Development 2008 Aug;135(16)2747-56
Cthrc1 protein, mouse  0   *Extracellular Matrix Proteins Glycoproteins. Gene Expr Patterns 2006 Oct;6(8):935-40
HAPLN3 protein, Xenopus  0   *Extracellular Matrix Proteins *Xenopus Proteins. Dev Biol 2008 Jul 1;319(1):34-45
cochlin protein, rat  0   *Extracellular Matrix Proteins. Neurosci Lett 2008 Mar 21;434(1):104-7
Otoc1 protein, zebrafish  0   *Extracellular Matrix Proteins *Zebrafish Proteins Calcium-Binding Proteins Phospholipases A2. Dev Neurobiol 2008 Feb 1;68(2):209-22
Matn2 protein, rat  0   *Glycoproteins *Extracellular Matrix Proteins. Matrix Biol 2007 Sep;26(7):554-60
Adamtsl2 protein, mouse  0   *Extracellular Matrix Proteins. Matrix Biol 2007 Jul;26(6):431-41
FAM20C protein, human  0   *Extracellular Matrix Proteins. Am J Hum Genet 2007 Nov;81(5):906-12
Wif1 protein, rat  0   *Extracellular Matrix Proteins *Intercellular Signaling Peptides and Proteins.
Frem3 protein, mouse  0   *Extracellular Matrix Proteins. Exp Cell Res 2005 May 15;306(1):9-23
Mepe protein, mouse  0   *Glycoproteins *Phosphoproteins *Extracellular Matrix Proteins. J Endocrinol 2007 Jan;192(1):261-7
hemicentin 2 protein, mouse  0   *Extracellular Matrix Proteins. J Histochem Cytochem 2007 Feb;55(2):119-26
hemicentin 1 protein, mouse  0   *Extracellular Matrix Proteins. J Histochem Cytochem 2007 Feb;55(2):119-26
Tnc protein, Drosophila  0   *Extracellular Matrix Proteins *Drosophila Proteins. Gene Expr Patterns 2006 Oct;6(8):772-6
DMP1 protein, human  0   *Phosphoproteins *Extracellular Matrix Proteins.
Dmp1 protein, mouse  0   *Extracellular Matrix Proteins.
Mia1 protein, mouse  0   *Extracellular Matrix Proteins Cartilage.
Oc90 protein, mouse  0   *Extracellular Matrix Proteins.
beta-tectorin, mouse  0   *Membrane Proteins *Extracellular Matrix Proteins Tectorial Membrane. Lab Invest 2006 Jul;86(7):645-53
Aspn protein, mouse  0   *Extracellular Matrix Proteins.
FAM20C protein, mouse  0   *Calcium-Binding Proteins *Extracellular Matrix Proteins. BMC Genomics 2005;6(1):11
noelin-4 protein, Xenopus  0   *Glycoproteins *Extracellular Matrix Proteins *Xenopus Proteins. Dev Biol 2005 Dec 15;288(2):434-47
CHI3L1 protein, rat  0   *Glycoproteins *Extracellular Matrix Proteins. J Biol Chem 2005 Dec 16;280(50):41213-21
CRELD2 protein, human  0   *Cell Adhesion Molecules *Extracellular Matrix Proteins Epidermal Growth Factor. Neurochem 2005 Dec;95(6):1585-96
Frem2 protein, mouse  0   *Extracellular Matrix Proteins. Proc Natl Acad Sci U S A 2005 Aug 16;102(33):11746-50
Matn2 protein, mouse  0   *Glycoproteins *Extracellular Matrix Proteins.
Dpt protein, mouse  0   *Chondroitin Sulfate Proteoglycans *Extracellular Matrix Proteins.
Slit3 protein, zebrafish  0   *Zebrafish Proteins *Intracellular Signaling Peptides and Proteins Calcium-Binding Proteins Nerve Tissue Proteins Extracellular Matrix Proteins. Dev Biol 2001 Feb 1;230(1):1-17
Sparcl1 protein, rat  0   *Calcium-Binding Proteins *Extracellular Matrix Proteins.
Sparcl1 protein, mouse  0   *Calcium-Binding Proteins *Extracellular Matrix Proteins.
SPARCL1 protein, human  0   *Calcium-Binding Proteins *Extracellular Matrix Proteins.
matrilin-4 protein, zebrafish  0   *Extracellular Matrix Proteins. Biochem J 2005 Mar 1;386(Pt 2):367-79
matrilin-3b protein, zebrafish  0   *Extracellular Matrix Proteins *Zebrafish Proteins. Biochem J 2005 Mar 1;386(Pt 2):367-79
matrilin-3a protein, zebrafish  0   *Extracellular Matrix Proteins *Zebrafish Proteins. Biochem J 2005 Mar 1;386(Pt 2):367-79
CTHRC1 protein, human  0   *Extracellular Matrix Proteins. Circ Res 2005 Feb 4;96(2):261-8
Scube2 protein, zebrafish  0   *Zebrafish Proteins *Extracellular Matrix Proteins. Curr Biol 2005 Mar 8;15(5):480-8
FREM2 protein, human  0   *Extracellular Matrix Proteins Fraser Syndrome. Nat Genet 2005 May;37(5):520-5
Kal-1 protein, Drosophila  0   *Extracellular Matrix Proteins *Drosophila Proteins. Gene Expr Patterns 2004 Nov;5(1):67-73
Optc protein, mouse  0   *Proteoglycans *Extracellular Matrix Proteins.
hensin protein, rabbit  0   *Extracellular Matrix Proteins *Receptors, Scavenger.
Snep protein, mouse  0   *Extracellular Matrix Proteins. Dev Dyn 2004 Jun;230(2):371-7
Lgals3bp protein, rat  0   *Carrier Proteins *Extracellular Matrix Proteins. Endocrinology 2004 Oct;145(10):4728-36
Frem1 protein, mouse  0   *Extracellular Matrix Proteins. Proc Natl Acad Sci U S A 2004 Sep 14;101(37):13560-5
FBLN5 protein, human  0   *Extracellular Matrix Proteins.
Fbln5 protein, rat  0   *Recombinant Proteins *Extracellular Matrix Proteins.
Efemp1 protein, mouse  0   *Extracellular Matrix Proteins.
Ush2a protein, mouse  0   *Extracellular Matrix Proteins.
Ush2a protein, rat  0   *Extracellular Matrix Proteins.
Coch protein, mouse  0   *Extracellular Matrix Proteins.
PCOLCE protein, human  0   *Glycoproteins *Extracellular Matrix Proteins.
PCOLCE2 protein, human  0   *Glycoproteins *Extracellular Matrix Proteins.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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