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NF-kappa B

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Definition: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.  DF: NFKB   
See Also I-kappa B Proteins
Examples NF-kappa B p50 Subunit; NF-kappa B p52 Subunit; Transcription Factor RelA; Transcription Factor RelB 		Other names kappa B Enhancer Binding Protein; Transcription Factor NF-kB; Nuclear Factor kappa B; Immunoglobulin Enhancer-Binding Protein; Transcription Factor NF kB; NF-kB, Transcription Factor; NF kappaB; NF kB; Immunoglobulin Enhancer Binding Protein; Ig EBP 1; Factor NF-kB, Transcription; Enhancer-Binding Protein, Immunoglobulin; NF-kappaB; NF-kB; Ig-EBP-1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3,11-dihydroxylup-20(29)-en-28-oic acid  0   *Triterpenes NF-kappa B/antagonists & inhibitors. Arch Pharm Res. 2004 Aug;27(8):825-8.
isopropyl 4-oxo-4-(2-oxopyrrolidin-1-yl)-2-butenoate  0   *Fumarates *Pyrrolidinones NF-kappa B/antagonists & inhibitors. BMB Rep 2011 Jul;44(7):468-72
2-benzo(1,3)dioxol-5-yl-N-(2-(benzothiazol-4-yloxymethyl)phenyl)-N-benzylacetamide  0   *Acetanilides *Benzothiazoles NF-kappa B/antagonists & inhibitors. Biochem Biophys Res Commun 2011 May 20;408(4):625-9
C1orf190 protein, human  0   *Tumor Suppressor Proteins NF-kappa B/agonists. J Immunol 2010 Dec 1;185(11):6719-27
rheosmin  0   *Butanones *Phenols NF-kappa B/antagonists & inhibitors. Food Chem Toxicol 2010 Aug-Sep;48(8-9):2148-53
4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine  0   *Phenylenediamines NF-kappa B/antagonists & inhibitors. FEBS Lett 2004 Jul 30;571(1-3):50-4
3-hydroxy-4,3',4',5'-tetramethoxychalcone  0   *Chalcones NF-kappa B/antagonists & inhibitors. J Med Chem 2009 Nov 26;52(22):7228-35
LRRC19 protein, human  0   *Receptors, Cell Surface NF-kappa B/agonists. Biochem Biophys Res Commun 2009 Oct 23;388(3):543-8
6,7-dihydroxy-3,4-dihydroisoquinoline  0   *Isoquinolines NF-kappa B/antagonists & inhibitors. Chemotherapy. 2009;55(3):175-82
SN52 peptide  0   *Peptides NF-kappa B/antagonists & inhibitors. Mol Cancer Ther 2008 Aug;7(8):2367-76
4-(3-benzyl-4-(5-(2-fluorophenyl)-ruan-2-ylmethylene)-5-oxo-4,5-dihydropyrazol-1-yl)benzoic acid  0   *Pyrazoles *Benzoic Acids NF-kappa B/antagonists & inhibitors. Biochem Biophys Res Commun 2008 Apr 18;368(4):1007-13
LC-1 compound  0   *Sesquiterpenes NF-kappa B/antagonists & inhibitors. J Surg Res 2007 Nov;143(1):169-76
ponapensin  0   *Heterocyclic Compounds, 3-Ring NF-kappa B/antagonists & inhibitors. Bioorg Med Chem Lett 2007 Jan 1;17(1):109-12
malloapelta B  0   *Benzopyrans NF-kappa B/antagonists & inhibitors. Arch Pharm Res 2006 Oct;29(10):840-4
eriocalyxin B  0   *Diterpenes NF-kappa B/antagonists & inhibitors. Phytochemistry 1995 Apr;38(6):1451-5
artemisolide  0   *Triterpenes NF-kappa B/antagonists & inhibitors. Arch Pharm Res 2006 Jul;29(7):591-7
flurizan  0   *Flurbiprofen Alzheimer Disease Amyloid beta-Peptides NF-kappa B. Drug News Perspect. 2005 Mar;18(2):141
N-(2,5-bis(trifluoromethyl)phenyl)-5-bromo-2-hydroxybenzamide  0   *Benzamides NF-kappa B/antagonists & inhibitors. Rheumatol 2005 Aug;32(8):1440-7
IkappaBgamma protein, human  0   *Peptide Fragments *Transcription Factors NF-kappa B/antagonists & inhibitors. Int J Immunopathol Pharmacol 2005 Jan-Mar;18(1):155-64
DSKB-2 compound  0   *Indans NF-kappa B/antagonists & inhibitors. FEBS Lett 2004 Dec 3;578(1-2):36-40
Unc5cl protein, mouse  0   *Carrier Proteins NF-kappa B/antagonists & inhibitors. J Biol Chem 2004 Apr 23;279(17):17819-25
3-(4-methylphenylsulfonyl)-2-propenenitrile  0   *Nitriles *Sulfones NF-kappa B/antagonists & inhibitors. Surgery 2001 Aug;130(2):143-50
BAY 11-7085  0   *Nitriles *Sulfones NF-kappa B/antagonists & inhibitors. J Infect Dis 2000 Nov;182(5):1437-45
NFKBIL1 protein, human  0   *Histocompatibility Antigens Class II Major Histocompatibility Complex NF-kappa B.
SN50 peptide  0   *Peptides NF-kappa B/antagonists & inhibitors. J Biol Chem 1995 Jun 16;270(24):14255-8
NKRF protein, human  0   *Repressor Proteins DNA-Binding Proteins NF-kappa B/antagonists & inhibitors. Immunobiology 1997 Dec;198(1-3):65-72
isohelenin  0   *Sesquiterpenes NF-kappa B/antagonists & inhibitors. FEBS Lett 1997 Jan 27;402(1):85-90
TONSL protein, human  0   *NF-kappa B. J Biol Chem 1995 May 5;270(18):10680-5
NF-kappa B kinase  EC 2.7.11.25   *Protein-Serine-Threonine Kinases NF-kappa B. J Biol Chem 1993 Dec 15;268(35):26790-5; Nature 1997 Feb 6;385(6616):540-4
I kappa B beta protein  0   *I-kappa B Proteins NF-kappa B/antagonists & inhibitors. Nucleic Acids Res 1992 Feb 11;20(3):607
p50B-p97 protein, human  146411-47-4   *Protein Precursors *NF-kappa B Transcription Factors. Mol Cell Biol 1992 Feb;12(2):685-95
NF-kappaB inhibitor alpha  139874-52-5   *I-kappa B Proteins NF-kappa B/antagonists & inhibitors. Cell 1991;65(7):1281
acetylleucyl-leucyl-norleucinal  110044-82-1   *Leupeptins Calpain/antagonists & inhibitors NF-kappa B/antagonists & inhibitors.
Pharma Action Cysteine Proteinase Inhibitors 		J Biochem (Tokyo) 1989;106(6):1035
caffeic acid phenethyl ester  104594-70-9   *Caffeic Acids Phenylethyl Alcohol/*analogs & derivatives Cytotoxins NF-kappa B/antagonists & inhibitors. Experientia 1988;44(3):230
pyrrolidine dithiocarbamic acid  25769-03-3 1-pyrrolidinecarbodithioic acid, ammonium salt  *Pyrrolidines *Thiocarbamates NF-kappa B/antagonists & inhibitors.
Pharma Action Antioxidants 		J Nutr 109(9):1623;1979
parthenolide  29552-41-8   *Sesquiterpenes NF-kappa B/antagonists & inhibitors Asteraceae Magnoliaceae.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal 		Arch Dermatol Forsch 251(3):235;1975; J Pharm Sci 62(2):345;1973; J Pharm Sci 66(6):883;1977; J Pharm Sci 67(3):347;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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