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Zinc Fingers

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Definition: Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.     
Examples RING Finger Domains 		Other names Zinc Finger Motif; Zinc Finger; Motifs, Zinc Finger; Motif, Zinc Finger; Fingers, Zinc; Finger, Zinc; Zinc Finger Motifs
 
SubstanceCAS Registry & nameCategoriesSource
toutatis protein, Drosophila  0   *Chromosomal Proteins, Non-Histone *Drosophila Proteins Zinc Fingers. Genet Res. 2001 Oct;78(2):137-48.
OZF2 protein, Arabidopsis  0   *Carrier Proteins *Arabidopsis Proteins Membrane Proteins Zinc Fingers. Plant Cell Physiol. 2012 Jan;53(1):193-203.
PHF20 protein, mouse  0   *Homeodomain Proteins Zinc Fingers. J Biol Chem. 2012 Jan 2;287(1):429-37
Zc3h12d protein, mouse  0   *Tumor Suppressor Proteins Zinc Fingers. Cell Signal. 2012 Feb;24(2):569-76.
ZBTB1 protein, mouse  0   *Repressor Proteins Zinc Fingers. J Exp Med. 2012 Jan 16;209(1)19-27
zinc finger protein 8, Arabidopsis  0   *Arabidopsis Proteins Zinc Fingers. Plant Physiol. 2011 Oct;157(2):673-82
zinc finger protein 5, Arabidopsis  0   *Arabidopsis Proteins Zinc Fingers. Plant Physiol. 2011 Oct;157(2):673-82
Lin28b protein, mouse  0   *DNA-Binding Proteins Zinc Fingers. Science. 2012 Mar 9;335(6073):1195-200
ZNF750 protein, human  0   *Transcription Factors Zinc Fingers. BMC Med Genet. 2011;12() (dup#107):167
ZNF292 protein, human  0   *Carrier Proteins *Nerve Tissue Proteins Zinc Fingers. Mol Psychiatry. 2011 Nov;16(11):1130-8.
OZF1 protein, Arabidopsis  0   *Membrane Proteins *Arabidopsis Proteins Zinc Fingers Oxidative Stress. J Plant Res. 2011 Nov;124(6):699-705
zinc finger protein 132 protein, human  0   *DNA-Binding Proteins *Transcription Factors Zinc Fingers. Int J Cancer. 2012 Feb 15;130(4):885-95
ZBTB1 protein, human  0   *Repressor Proteins Zinc Fingers. Mol Cell Biochem. 2011 Nov;357(1-2):405-14.
Oaz protein, Xenopus  0   *Transcription Factors *Xenopus Proteins DNA-Binding Proteins Zinc Fingers. PLoS One. 2011;6(8):e22621.
ZNF511-PRAP1 protein, human  0   *Transcription Factors Zinc Fingers. Mol Ther. 2011 Aug;19(8):1478-86
rhinoceros protein, Drosophila  0   *Homeodomain Proteins *Drosophila Proteins Nuclear Proteins Zinc Fingers. Genetics. 2003 Dec;165(4):1993-2006.
ZNF206 protein, human  0   *Transcription Factors Zinc Fingers. Stem Cells. 2007 Sep;25(9):2173-82.
TIEG2 protein, rat  0   *Trans-Activators Zinc Fingers. Genomics. 2000 Nov 15;70(1):93-101.
Lsy-27 protein, C elegans  0   *Transcription Factors *Caenorhabditis elegans Proteins Zinc Fingers. Genetics. 2011 Jul;188(3):753-9.
HOMEZ protein, Xenopus  0   *Transcription Factors *Homeodomain Proteins *Xenopus Proteins Zinc Fingers Leucine Zippers. Biochem Biophys Res Commun. 2011 Nov 11;415(1):11-6
TSHZ1 protein, human  0   *Homeodomain Proteins Antigens, Neoplasm Zinc Fingers. Int J Oncol. 2011 Nov;39(5):1143-51.
zinc finger protein 577, human  0   *DNA-Binding Proteins *Transcription Factors Zinc Fingers. J Clin Pathol. 2011 Nov;64(11):1010-3
ZNF668 protein, human  0   *Tumor Suppressor Proteins Zinc Fingers. Cancer Res. 2011 Oct 15;71(20):6524-34.
Pirh2 protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases Zinc Fingers. Mol Cell Biol. 2011 Oct;31(19):3997-4006.
BBX32 protein, Arabidopsis  0   *Carrier Proteins *Arabidopsis Proteins Zinc Fingers. Plant Physiol. 2011 Aug;156(4):2109-23
SOMI-1 protein, C elegans  0   *DNA-Binding Proteins *Caenorhabditis elegans Proteins Nuclear Proteins Zinc Fingers. Genes Dev 2011 Oct 1;25(19):2079-82
Salr protein, Drosophila  0   *Repressor Proteins *Drosophila Proteins Zinc Fingers. Biochem J 2011 Sep 15;438(3):437-45
BRD1 protein, mouse  0   *Trans-Activators Zinc Fingers. Blood 2011 Sep 1;118(9):2443-53
zinc finger protein 510, human  0   *DNA-Binding Proteins Zinc Fingers. Clin Chim Acta. 2011 Jul 15;412(15-16):1357-65
RHA2b protein, Arabidopsis  EC 6.3.2.19   *Arabidopsis Proteins *Ubiquitin-Protein Ligases Zinc Fingers. Plant Physiol 2011 Jun;156(2):550-63
Snail2 protein, Xenopus  0   *Transcription Factors *Xenopus Proteins Zinc Fingers. Development 2011 Aug;138(15):3135-45
ZIFCAT protein, human  0   *DNA-Binding Proteins *Nuclear Proteins Repressor Proteins Zinc Fingers. J Biol Chem 2011 Jul 1;286(26):23178-88
Fezf1 protein, mouse  0   *DNA-Binding Proteins *Nerve Tissue Proteins Zinc Fingers. J Comp Neurol. 2011 Jul 1;519(10):1829-46
ZNF689 protein, human  0   *Transcription Factors *Apoptosis Regulatory Proteins Zinc Fingers. Exp Cell Res 2011 Aug 1;317(13):1851-9
ZBTB24 protein, human  0   *Repressor Proteins Zinc Fingers. Am J Hum Genet 2011 Jun 10;88(6):796-804
DNLZ protein, human  0   *Molecular Chaperones Zinc Fingers. Biochem Biophys Res Commun 2011 May 20;408(4):589-94
Glis1 protein, mouse  0   *DNA-Binding Proteins *Transcription Factors Zinc Fingers. Nature. 2011;474(7350):225-9
ATL9 protein, Arabidopsis  EC 6.3.2.19   *Ubiquitin-Protein Ligases Zinc Fingers. PLoS One 2010;5(12):e14426
ZCCHC9 protein, human  0   *Nuclear Proteins *RNA-Binding Proteins Zinc Fingers. J Genet Genomics 2008 Aug;35(8):467-72
HOMEZ protein, human  0   *Transcription Factors *Homeodomain Proteins Zinc Fingers Leucine Zippers. PLoS One. 2010;5(4) (dup#6):e10286
ZBTB42 protein, mouse  0   *Muscle Proteins *Nuclear Proteins Zinc Fingers. Hum Genet 2011 Apr;129(4):433-41
ZBTB42 protein, human  0   *Muscle Proteins *Nuclear Proteins Zinc Fingers. Hum Genet 2011 Apr;129(4):433-41
JAZF1 protein, mouse  0   *Carrier Proteins *Nuclear Proteins Zinc Fingers. Metabolism 2011 Apr;60(4):523-30
ZNRF4 protein, human  0   *DNA-Binding Proteins Zinc Fingers. J Biol Chem. 2011 Mar 11;286(10):8633-43
Zbtb45 protein, mouse  0   *Transcription Factors Zinc Fingers. Cell Cycle 2010 Dec 15;9(24):4866-75
zinc finger protein 425, human  0   *Repressor Proteins Zinc Fingers. BMB Rep. 2011 Jan;44(1):58-63
ZNF431 protein, mouse  0   *Transcription Factors Zinc Fingers. J Biol Chem 2011 Mar 4;286(9):7279-89
ZNF746 protein, mouse  0   *Repressor Proteins Zinc Fingers. Cell. 2011 Mar 4;144(5):689-702
Zeppo1 protein, mouse  0   *Repressor Proteins Zinc Fingers. Genes Dev 2011 Mar 1;25(5):471-84
RNF170 protein, human  0   *Ubiquitin-Protein Ligases Zinc Fingers. Brain 2011 Feb;134(Pt 2):602-7
DBB1a protein, Arabidopsis  0   *Carrier Proteins *Arabidopsis Proteins Nuclear Proteins Zinc Fingers. Planta 2011 Jan;233(1):13-23
ZNF312 protein, human  0   *Transcription Factors Zinc Fingers. Neurosci Res 2010 Sep;68(1):73-6
BBX21 protein, Arabidopsis  0   *Transcription Factors *Arabidopsis Proteins Zinc Fingers. Plant J 2010 Nov;64(4):551-62
ZNF533 protein, human  0   *Repressor Proteins Zinc Fingers. DNA Cell Biol 2011 Jan;30(1):47-54
chromosome alignment-maintaining phosphoprotein, human  0   *Chromosomal Proteins, Non-Histone *Phosphoproteins Zinc Fingers. EMBO J 2011 Jan 5;30(1):130-44
ZAS3 protein, human  0   *DNA-Binding Proteins *Transcription Factors Zinc Fingers. Cell Signal. 2011 Jan;23(1):105-13
ZNF592 protein, human  0   *DNA-Binding Proteins Zinc Fingers. Eur J Hum Genet. 2010 Oct;18(10):1107-13
ZRANB3 protein, human  EC 3.6.4.-   *DNA Helicases Zinc Fingers. Proc Natl Acad Sci U S A 2010 Dec 7;107(49):20970-3
TRIM24 protein, human  0   *Carrier Proteins Zinc Fingers. Nature. 2010 Dec 16;468(7326):927-32
SOBP protein, human  0   *Carrier Proteins *Nuclear Proteins Zinc Fingers. Am J Hum Genet 2010 Nov 12;87(5):694-700
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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