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Leucine Zippers

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Definition: DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.      Other names Zippers, Leucine; Zipper, Leucine; Leucine Zipper
 
SubstanceCAS Registry & nameCategoriesSource
HOMEZ protein, Xenopus  0   *Transcription Factors *Homeodomain Proteins *Xenopus Proteins Zinc Fingers Leucine Zippers. Biochem Biophys Res Commun. 2011 Nov 11;415(1):11-6
LZTS2 protein, mouse  0   *DNA-Binding Proteins *Cell Cycle Proteins *Tumor Suppressor Proteins Leucine Zippers. J Biol Chem. 2011 Nov 18;286(46):40331-42
Crlz1 protein, human  0   *Trans-Activators Leucine Zippers. Mol Cells. 2011 Jul;32(1):67-76.
LAPSER1 protein, Xenopus  0   *Tumor Suppressor Proteins *Xenopus Proteins Leucine Zippers. Dev Dyn 2011 Jun;240(6):1528-36
HOMEZ protein, human  0   *Transcription Factors *Homeodomain Proteins Zinc Fingers Leucine Zippers. PLoS One. 2010;5(4) (dup#6):e10286
CTNNBL1 protein, mouse  0   *Nuclear Proteins *Apoptosis Regulatory Proteins Leucine Zippers Apoptosis beta Catenin. J Immunol. 2010 Aug 1;185(3):1379-81
CAZIP protein, mouse  0   *Carrier Proteins Leucine Zippers. Dev Dyn 2009 Nov;238(11):2903-11
CAZIP protein, human  0   *Carrier Proteins Leucine Zippers. Dev Dyn 2009 Nov;238(11):2903-11
SNFT protein, mouse  0   *Repressor Proteins *Basic-Leucine Zipper Transcription Factors Nuclear Proteins Leucine Zippers. Science 2008 Nov 14;322(5904):1097-100
bZIP28 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic-Leucine Zipper Transcription Factors Leucine Zippers. Plant Cell 2007 Dec;19(12):414-9
bunched protein, Drosophila  0   *DNA-Binding Proteins *Drosophila Proteins Leucine Zippers. Proc Natl Acad Sci U S A 2008 Apr 8;105(14):5414-9
FLX protein, Arabidopsis  0   *Arabidopsis Proteins Leucine Zippers. Plant Cell Physiol 2008 Feb;49(2):191-200
tamalin protein, mouse  0   *Carrier Proteins *Membrane Proteins Phosphoproteins Leucine Zippers. Proc Natl Acad Sci U S A 2007 Sep 11;104(37):14789-94
ATHB23 protein, Arabidopsis  0   *Homeodomain Proteins *Arabidopsis Proteins Leucine Zippers. Plant Cell Rep 2007 Aug;26(8):1179-85
LAPSER1 protein, rat  0   *Membrane Proteins *Tumor Suppressor Proteins Leucine Zippers. FASEB J 2007 Jul;21(9):2086-100
NEMO protein, mouse  0   *Intracellular Signaling Peptides and Proteins Leucine Zippers. Cell 1998 Jun 26;93(7):1231-40
PspD protein, E coli  0   *Membrane Proteins *Escherichia coli Proteins Leucine Zippers. J Biol Chem 2006 Jul 28;281(30):21147-61
cryptocephal protein, Drosophila  0   *Transcription Factors *Drosophila Proteins Leucine Zippers. J Exp Biol 2006 May;209(Pt 10):1803-15
GRP23 protein, Arabidopsis  0   *Transcription Factors *Arabidopsis Proteins Leucine Zippers. Plant Cell 2006 Apr;18(4):815-30
Tex24 protein, mouse  0   *DNA-Binding Proteins *Nuclear Proteins Leucine Zippers. Biochem Biophys Res Commun 2006 Feb 3;340(1):8-12
Daple-like protein, Xenopus  0   *Xenopus Proteins *Intracellular Signaling Peptides and Proteins Leucine Zippers. Mech Dev 2005 Oct;122(10):1138-53
Atf7a protein, zebrafish  0   *Zebrafish Proteins *Activating Transcription Factors Leucine Zippers. Dev Dyn 2005 Jul;233(3):1157-62
Pcd17 protein, mouse  0   *Antigens, Surface Leucine Zippers Paraneoplastic Cerebellar Degeneration. J Autoimmun 2005 May;24(3):203-8
cereblon protein, rat  0   *Carrier Proteins Leucine Zippers. J Neurochem 2005 Sep;94(5):1212-24
Lisch7 protein, rat  0   *Receptors, LDL *Transcription Factors Leucine Zippers Helix-Loop-Helix Motifs. J Biol Chem 1999 May 7;274(19):13390-8
LZTS3 protein, human  0   *Tumor Suppressor Proteins Leucine Zippers. Oncol Rep 2005 Aug;14(2):547-51
FIAT protein, mouse  0   *Carrier Proteins *Nuclear Proteins Leucine Zippers. J Cell Biol 2005 May 23;169(4):591-601
NOC3L protein, human  0   *Nuclear Proteins *Basic-Leucine Zipper Transcription Factors Leucine Zippers. J Cell Sci 2004 Dec 1;117(Pt 25):6217-26
Noc3l protein, mouse  0   *Nuclear Proteins *Basic-Leucine Zipper Transcription Factors Leucine Zippers. J Cell Sci 2004 Dec 1;117(Pt 25):6217-26
TSC-22 protein, Xenopus  0   *Repressor Proteins *Xenopus Proteins Leucine Zippers. Dev Growth Differ. 2004 Dec;46(6):535-44
AREB3 protein, Arabidopsis thaliana  0   *Arabidopsis Proteins *Basic-Leucine Zipper Transcription Factors Leucine Zippers. J Exp Bot 2005 Feb;56(412):597-603
Zip67 protein, Arabidopsis  0   *Repressor Proteins *Arabidopsis Proteins *Basic-Leucine Zipper Transcription Factors Leucine Zippers. J Exp Bot 2005 Feb;56(412):597-603
Sart1 protein, rat  0   *Antigens, Neoplasm *Ribonucleoproteins, Small Nuclear DNA-Binding Proteins Leucine Zippers.
Dbp protein, mouse  0   *DNA-Binding Proteins *Transcription Factors Circadian Rhythm Leucine Zippers.
DLK-1 protein, C elegans  EC 2.7.1.37   *MAP Kinase Kinase Kinases *Caenorhabditis elegans Proteins Leucine Zippers. Cell 2005 Feb 11;120(3):407-20
ATHB7 protein, Arabidopsis  0   *Homeodomain Proteins *Arabidopsis Proteins Leucine Zippers. Plant Mol Biol 2004 Jul;55(5):663-77
CCDC110 protein, human  0   *Antigens, Neoplasm *Nuclear Proteins Leucine Zippers. Clin Cancer Res 2004 Sep 15;10(18 Pt 1):6047-57
Evc protein, rat  0   *Membrane Proteins *Nuclear Proteins Ellis-Van Creveld Syndrome Leucine Zippers. Anat Rec 2004 Aug;279A(2):729-35
HD-Zip protein, Arabidopsis  0   *Homeodomain Proteins *Arabidopsis Proteins Leucine Zippers. Plant Physiol 2004 Aug;135(4):2261-70
Cspg6 protein, mouse  0   *Cell Cycle Proteins *Chromosomal Proteins, Non-Histone *Chondroitin Sulfate Proteoglycans Adenosine Triphosphatases DNA-Binding Proteins Leucine Zippers.
SOX13 protein, human  0   *Autoantigens *SOXD Transcription Factors Leucine Zippers.
BACH2 protein, human  0   *Basic-Leucine Zipper Transcription Factors Leucine Zippers.
Tgfb1i4 protein, mouse  0   *Repressor Proteins Leucine Zippers.
Tgfb1i4 protein, rat  0   *Repressor Proteins Leucine Zippers.
Rgl2 protein, mouse  0   *Transcription Factors Zinc Fingers Leucine Zippers.
RLF protein, Xenopus  0   *Transcription Factors *Xenopus Proteins Zinc Fingers Leucine Zippers.
HLF protein, human  0   *Basic-Leucine Zipper Transcription Factors Leucine Zippers.
Hlf protein, mouse  0   *Basic-Leucine Zipper Transcription Factors Leucine Zippers.
Map3k10 protein, mouse  EC 2.7.11.25   *MAP Kinase Kinase Kinases Leucine Zippers.
mlk2 protein, Xenopus  EC 2.7.1.-   *MAP Kinase Kinase Kinases *Xenopus Proteins Leucine Zippers.
Mllt10 protein, mouse  0   *Transcription Factors Zinc Fingers Leucine Zippers Myeloid-Lymphoid Leukemia Protein.
ATF3 protein, human  0   *Activating Transcription Factor 3 Leucine Zippers. J Biol Chem 1994 Jun 3;269(22):15819-26
krml2 protein, zebrafish  0   *Oncogene Proteins *Zebrafish Proteins *Maf Transcription Factors Leucine Zippers.
MAFB protein, human  0   *MafB Transcription Factor Leucine Zippers.
Mafb protein, mouse  0   *MafB Transcription Factor Leucine Zippers.
Mafb protein, rat  0   *Oncogene Proteins *MafB Transcription Factor Leucine Zippers.
Sprk protein, rat  EC 2.7.1.-   *Protein-Serine-Threonine Kinases Leucine Zippers.
NRL protein, human  0   *Eye Proteins *Basic-Leucine Zipper Transcription Factors Transcription Factors Leucine Zippers.
E2a-Hlf fusion protein, mouse  0   *Oncogene Proteins, Fusion *Basic-Leucine Zipper Transcription Factors Leucine Zippers.
tef protein, zebrafish  0   *Zebrafish Proteins *Basic-Leucine Zipper Transcription Factors Leucine Zippers.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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