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Tacrolimus

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Definition: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.     
Pharmacological Action Immunosuppressive Agents 		Other names Tacrolimus, Anhydrous; FR900506; FR 900506; FK 506; Prograft; Prograf; Janssen Brand of Tacrolimus; Fujisawa Brand of Tacrolimus; FR-900506; Cilag Brand of Tacrolimus; Anhydrous Tacrolimus; FK-506; FK506Drugs* : TACROLIMUS; PROGRAF; PROTOPIC
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AP23510  0   Tacrolimus/*analogs & derivatives. Lab Invest 2007 Aug;87(8):828-35
FK1706  0   Tacrolimus/*analogs & derivatives. Eur J Pharmacol. 2005 Feb 10;509(1):11-9
13-O-demethyl tacrolimus  0   Tacrolimus/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jul 5;821(1):31-7
17-allyl-1,14-dihydroxy-12-(3-(3-methoxy-4-(4-methoxycarbonylmethylphenylenecarbamoyloxy)cyclohexyl)-1-methylvinyl)-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo(22.3.1.0(4,9))octacos-18-ene-2,3,10,16-tetraone  0   Tacrolimus/*analogs & derivatives. J Med Chem 2004 Sep 23;47(20):4950-7
Fkbp3 protein, mouse  0   *Tacrolimus Binding Proteins Tacrolimus.
GPI 1485  0   Tacrolimus/*analogs & derivatives. Curr Opin Investig Drugs 2004 Jan;5(1):107-12
JNJ460  0   Tacrolimus/*analogs & derivatives. Neuroscience 2004;124(2);351-66
AP20187  0   Tacrolimus/*analogs & derivatives. Gene Ther 2002 Apr;9(7):444-51
13-desmethoxy-13-methyl-FK 520  0   Tacrolimus/*analogs & derivatives. J Ind Microbiol Biotechnol 2002 Jan;28(1):12-6
15-O-desmethyl-FK 520  0   Tacrolimus/*analogs & derivatives. Curr Biol 1999 Sep 9;9(17):967-70
C24-deoxyascomycin  0   Tacrolimus/*analogs & derivatives. J Med Chem 1999 Oct 21;42(21):4456-61
AP 1889  0   Tacrolimus/*analogs & derivatives. Methods Enzymol 1999;306:263-8
AP 1510  0   Tacrolimus/*analogs & derivatives. J Biol Chem 1999 Jun 11;274(24):17171-8
pimecrolimus  0   Tacrolimus/*analogs & derivatives Peptidylprolyl Isomerase/antagonists & inhibitors Calcineurin/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Dermatologic Agents ; Immunosuppressive Agents 		J Pharmacol Exp Ther 1999 Feb;288(2):653-9ELIDEL
L 733725  0   *Imidazoles Tacrolimus/*analogs & derivatives. Bioorg Med Chem Lett 1998 Aug 18;8(16):2253-8
FK 506-dextran conjugate  0   *Dextrans *Tacrolimus. Transplant Proc 1998 Jun;30(4):1029-30
32-ascomycinyloxyacetic acid  0   Tacrolimus/*analogs & derivatives. J Med Chem 1998 May 21;41(11):1764-76
32-O-(1-hydroxyethylindol-5-yl)ascomycin  0   Tacrolimus/*analogs & derivatives. Transplantation 1998 Jan 15;65(1):10-8
9-deoxo-31-O-demethyl-FK506  0   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1997 May;50(5):418-23
31-O-demethyl-FK506  135635-47-1   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1997 May;50(5):418-23
A 85917  0   Tacrolimus/*analogs & derivatives. Transplant Proc 1996 Dec;28(6):3185-8
dexamethasone-FK506 heterodimer  0   Dexamethasone/*analogs & derivatives Tacrolimus/*analogs & derivatives. Proc Natl Acad Sci U S A 1996 Nov 12;93(23):12817-21
antascomicin E  0   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1996 Mar;49(3):230-3
antascomicin D  0   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1996 Mar;49(3):230-3
antascomicin C  0   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1996 Mar;49(3):230-3
antascomicin B  0   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1996 Mar;49(3):230-3
antascomicin A  0   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1996 Mar;49(3):230-3
SDZ 281-240  0   Tacrolimus/*analogs & derivatives. J Invest Dermatol 1996 Apr;106(4):701
L 688617  0   Tacrolimus/*analogs & derivatives. J Pharmacol Exp Ther 1996 Mar;276(3):1078-88
32-O-acetyltacrolimus  0   Tacrolimus/*analogs & derivatives. Ther Drug Monit 1995 Oct;17(5):504-10
CP 123369  0   Tacrolimus/*analogs & derivatives. Inflamm Res 1995 Aug;44 Suppl 2:S183-4
FK506-binding protein 33, Streptomyces chrysomallus  0   *Bacterial Proteins *Tacrolimus Binding Proteins Tacrolimus. EMBO J 1994 Aug 1;13(15):3472-80
15,31-desmethyl FK-506  0   Tacrolimus/*analogs & derivatives. Clin Chem 1994 May;40(5):740-4
15-desmethyl FK-506  0   Tacrolimus/*analogs & derivatives. Clin Chem 1994 May;40(5):740-4
FK 1012  0   Tacrolimus/*analogs & derivatives. Science 1993 Nov 12;262(5136):989
13,15-O-bidesmethylascomycin  153781-49-8   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1993 Sep;46(9):1397-1405
13-O-desmethylascomycin  153781-48-7   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1993 Sep;46(9):1397-1405
15-O-desmethylascomycin  141170-83-4   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1993 Sep;46(9):1397-1405
L 683590  133876-12-7 L 683-590  Tacrolimus/*analogs & derivatives. Transplantation 1993 Jan;55(1):186-92
L 685818  143839-74-1 15,19-Epoxy-(3H)-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,11,19-trihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tet  Tacrolimus/*analogs & derivatives. J Exp Med 1992 Sep 1;176(3):751-60
FKBP3 protein, human  147478-69-1   *Tacrolimus Binding Proteins Tacrolimus. J Biol Chem 1992 Jun 5;267(16):10942-5
L 683519  132172-14-6   Tacrolimus/*analogs & derivatives. J Antibiot (Tokyo) 1992 Apr;45(4):577-80
FKBP-13  142192-36-7   *Tacrolimus Binding Proteins Tacrolimus. Proc Natl Acad Sci USA 1991;88(15):6677
immunomycin  104987-12-4 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetram  Tacrolimus/*analogs & derivatives.
Pharma Action Anti-Bacterial Agents ; Immunosuppressive Agents 		J Antibiot (Tokyo) 1988;41(11):1592

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