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Lupus Coagulation Inhibitor

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Definition: An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.  DF: LUPUS COAG INHIB   
Pharmacological Action Immunologic Factors
See Also Antiphospholipid Syndrome
Other names Lupus Anticoagulant; Inhibitor, Lupus Coagulation; Coagulation Inhibitor, Lupus; Anticoagulant, Lupus

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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