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Monocrotaline

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Definition: A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.      Other names Monocrotaline, (all-xi)-Isomer; Monocrotaline Hydrochloride (13alpha,14alpha)-Isom
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-cysteinyldehydroretronecine  64660-85-1   Cysteine/*analogs & derivatives Monocrotaline/*analogs & derivatives. Adv Exp Med Biol 1991;283:605
monocrotaline pyrrole  23291-96-5   Monocrotaline/*analogs & derivatives.
Pharma Action Alkylating Agents ; Cross-Linking Reagents 		Arch Pathol Lab Med 101(2):69;1977; Pathology 8(1):7;1976
dehydroretronecine  26400-45-3   Monocrotaline/*analogs & derivatives.
Pharma Action Carcinogens 		Cancer Res 35(4):997;1975; Cancer Res 37(9):3141;1977; Chem Biol Interact 13(3-4):243;1976; Chem Biol Interactions 12(1):19;1976; Fd Cosmet Tox 15(5):419;1977; J Nat Cancer Inst 56(4):787;1976; J Natl Cancer Inst 61(1):85;1978; Mol Pharmacol 14(6):1189;1978; Proc Soc Exp Biol Med 144(3):834;1973; Res Comm Chem Pathol Pharmacol 11(1):79;1975
trichodesmine  548-90-3 (13 alpha,14 alpha)-14,19-dihydro-12,13-dihydroxy-19-methylcrotalanan-11,15-dione  Monocrotaline/*analogs & derivatives. Farmatsiia 21(5):49;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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