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Proto-Oncogene Proteins c-jun

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Definition: Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.  /drug eff /ultrastruct permitted; DF: note short X refs   
See Also Transcription Factor AP-1 		Other names p39(c-jun); jun Proto-Oncogene Proteins; jun D Proteins; jun B Proteins; fos-Associated Protein p39; c-jun Proteins; c-fos-Associated Protein p39; p39 c jun; jun Proto Oncogene Proteins; jun Proto Oncogene Product p39; fos Associated Protein p39; c jun Proteins; c fos Associated Protein p39; Proto Oncogene Proteins jun; Proto Oncogene Proteins c jun; Proto Oncogene Products c jun; p39 c-jun; jun Proto-Oncogene Product p39; Proto-Oncogene Proteins jun; Proto-Oncogene Products c-jun
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
JunD protein, human  0   *Proto-Oncogene Proteins c-jun. Biochim Biophys Acta. 2011 May;1813(5):731-41
JunD protein, rat  0   *Proto-Oncogene Proteins c-jun. Am J Physiol Cell Physiol 2010 May;298(5):C1226-34
junD protein, mouse  0   *Proto-Oncogene Proteins c-jun. J Biol Chem 2008 Mar 14;283(11):6687-95
TAM67 peptide  0   *Peptide Fragments *Proto-Oncogene Proteins c-jun. Am J Physiol Gastrointestinal Liver Physiol 2001 Nov;281(5):G1279-89
Oct-1-associated protein 40  0   *Proto-Oncogene Proteins c-jun Leucine Zippers. Genes Dev 1993 Feb;7(2):188-96
nuclear factor-jun  0   *Proto-Oncogene Proteins c-jun Transcription Factors. EMBO J 1992 Apr;11(4):1479-86

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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