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Lipoxygenase Inhibitors

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Definition: Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.      Other names Inhibitors, Arachidonate 5-Lipoxygenase; Inhibitors, Arachidonate 15-Lipoxygenase; Inhibitors, Arachidonate 12-Lipoxygenase; Inhibitors, 5-Lipoxygenase; Inhibitors, 15-Lipoxygenase; Inhibitors, 12-Lipoxygenase; Arachidonate 5 Lipoxygenase Inhibitors; Arachidonate 15 Lipoxygenase Inhibitors; Arachidonate 12 Lipoxygenase Inhibitors; 5-Lipoxygenase Inhibitors, Arachidonate; 15-Lipoxygenase Inhibitors, Arachidonate; 15 Lipoxygenase Inhibitors; 5 Lipoxygenase Inhibitors; 12-Lipoxygenase Inhibitors, Arachidonate; 12 Lipoxygenase Inhibitors; Inhibitors, Lipoxygenase; Arachidonate 5-Lipoxygenase Inhibitors; Arachidonate 15-Lipoxygenase Inhibitors; Arachidonate 12-Lipoxygenase Inhibitors; 5-Lipoxygenase Inhibitors
Substances having this pharmacologic action: nafazatrom; azelastine; 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid; piriprost; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; Diethylcarbamazine; Nordihydroguaiaretic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; benoxaprofen; phenidone; atreleuton; 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid; S(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid; N-hydroxy-N-(1-(4-(phenylmethoxy)phenyl)ethyl)-acetamide; L 663536; zileuton; 4-bromo-2,7-dimethoxy-3H-phenothiazin-3-one; N-(3-phenoxycinnamyl)acetohydroxamic acid; 9-hydroperoxy-11,12-octadecadienoic acid; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(4-(biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid  0   *Octanoic Acids *Pyrimidines Lipoxygenase Inhibitors. Br J Pharmacol. 2011 Sep;164(2b):781-93.
LP105 compound  0   *Pyrimidines Lipoxygenase Inhibitors. Br J Pharmacol. 2011 Aug;163(8):1721-32
4-(4-fluorophenyl)-7-(((5-(1-hydroxy-1-(trifluoromethyl)propyl)-1,3,4-oxadiazol-2-yl)amino)methyl)-2H-1-benzopyran-2-one  0   *Coumarins *Oxadiazoles Lipoxygenase Inhibitors. Drug Metab Dispos. 2011 May;39(5):763-70.
2-(4-(3-biphenyloxypropoxy)phenylthio)hexanoic acid  0   *Hexanoic Acids Lipoxygenase Inhibitors. Bioorg Med Chem 2011 Jun 1;19(11):3394-401
ethyl 4-(benzyloxy)-3-((3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methylsulfonamido)benzoate  0   *Benzoates *Sulfonamides Lipoxygenase Inhibitors Cyclooxygenase Inhibitors Cyclooxygenase 1 Cyclooxygenase 2 Inhibitors. Bioorg Med Chem 2011 Mar 15;19(6):2074-83
(2-fluorobenzyl)-(2-methyl-2-phenyl-2H-chromen-6-yl-amine)  0   *Benzopyrans *Benzylamines Lipoxygenase Inhibitors. Cell Biochem Funct. 2011 Mar;29(2):126-34
2-(4-chlorophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one  0   *Benzylidene Compounds *Thiazoles Lipoxygenase Inhibitors. J Med Chem 2011 Mar 24;54(6):1943-7
LY 270766  152923-58-5   Organic Chemicals Lipoxygenase Inhibitors. J Neurochem 1993 Apr;60(4):1365-71
RHC 5901  0   Organic Chemicals Lipoxygenase Inhibitors. Endocrinology 1991;129(6):2886
CGS 5677  100365-93-3 CGS 5677  Organic Chemicals Lipoxygenase Inhibitors. Prostaglandins 1984;28(4):557

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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