Definition: Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.
do not coordinate with specific endocrine disease term or CANDIDIASIS unless particularly discussed
Other names Schmidt's Syndrome; Polyglandular Type II Autoimmune Syndrome; Polyglandular Type I Autoimmune Syndrome; Autoimmune Syndrome Type II, Polyglandular; Autoimmune Syndrome Type I, Polyglandular; Autoimmune Polyendocrinopathy-Candidiasis-Ectoderm; Syndrome, Schmidt's; Schmidts Syndrome; Schmidt Syndrome; Polyendocrinopathy-Candidiasis-Ectodermal-Dystroph; Polyendocrinopathy-Candidiasis-Ectodermal-Dystroph; Polyendocrinopathy, Autoimmune; Autoimmune Polyendocrinopathy-Candidiasis-Ectoderm; Autoimmune Polyendocrinopathy Candidiasis Ectoderm; Autoimmune Polyendocrinopathy; Polyglandular Type III Autoimmune Syndrome; Polyglandular Deficiency Syndrome, Type 2; Polyglandular Autoimmune Syndrome, Type 3; Polyglandular Autoimmune Syndrome, Type 2; Polyglandular Autoimmune Syndrome, Type 1
