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Interferon-alpha

More information in Books or onNLM PubMed
Definition: One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.     
Pharmacological Action Antiviral Agents; Immunologic Factors 		Other names Interferon, alpha; Interferon, Lymphoblastoid; Interferon alpha5; Interferon alpha4; Interferon alpha-T; Interferon alpha-J; Interferon alpha-A; Interferon alpha-88; Interferon alpha-7; Interferon alpha-5; Interferon alpha-4; Interferon alpha-2; Interferon alpha-17; Interferon alpha-1; IFN-alpha5; IFN-alpha-2; IFN-alpha D; IFN-alpha 2; alpha-Interferon; Interferon, LymphoblastDrugs* : ALFERON N INJECTION
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PEG-IFN-SA  0   *Polyethylene Glycols *Interferon-alpha. Regul Pept. 2012 Jan 10;173(1-3):74-81.
Ifrg15 protein, mouse  0   *Interferon-alpha. J Mol Histol. 2010 Oct;41(4-5):185-91
Ifna14 protein, mouse  0   *Interferon-alpha.
Ifna13 protein, mouse  0   *Interferon-alpha.
Ifna3 protein, mouse  0   *Interferon-alpha.
Ifna2 protein, mouse  0   *Interferon-alpha.
Ifna10 protein, mouse  0   *Interferon-alpha.
Ifna1 protein, mouse  0   *Interferon-alpha.
Ifna protein, mouse  0   *Interferon-alpha.
IFNA21 protein, human  0   *Interferon-alpha.
IFNA14 protein, human  0   *Interferon-alpha.
IFNA13 protein, human  0   *Interferon-alpha.
IFNA8 protein, human  0   *Interferon-alpha.
IFNA6 protein, human  0   *Interferon-alpha.
IFNA7 protein, human  0   *Interferon-alpha.
IFNA5 protein, human  0   *Interferon-alpha.
IFNA4 protein, human  0   *Interferon-alpha.
IFNA2 protein, human  0   *Interferon-alpha.
IFNA1 protein, human  0   *Interferon-alpha.
interferon alfa-n1  0   *Interferon-alpha.
interferon alfa-2c  0   *Interferon-alpha Recombinant Proteins.
interferon alfa-2b  99210-65-8   *Interferon-alpha Recombinant Proteins.
Interferon Alfa-n3  0   *Interferon-alpha.
interferon alfa-2a  76543-88-9   *Interferon-alpha Recombinant Proteins.
human serum albumin-interferon-alpha-2b fusion protein  0   *Serum Albumin *Interferon-alpha Recombinant Fusion Proteins. Pharmacology 2009;83(6):323-32
albinterferon alfa-2b  0   *Albumins *Interferon-alpha. Hepatology. 2008 Aug;48(2):407-17
Ifna12 protein, mouse  0   *Interferon-alpha. Cytokine 2007 Feb;37(2):138-49
interferon-alpha, immunoglobulin-linked  0   *Immunoglobulins *Interferon-alpha Recombinant Fusion Proteins. Drug Chem Toxicol 2007;30(1):83-95
albumin interferon  0   *Recombinant Fusion Proteins Serum Albumin Interferon-alpha. Nat Clin Pract Gastroenterol Hepatol 2007 Feb;4(2):60-1
cyclo((Gly)2-interferon alpha2b(122-137)-Gly(138)-Gly(139)-interferon alpha2b(30-35)-(Gly)2)  0   *Peptides, Cyclic *Interferon-alpha. Peptides 2005 Jul;26(7):1144-9
(Gly)2-interferon alpha2b(122-137)-Gly(138)-Gly(139)-interferon alpha2b(30-35)-(Gly)2  0   *Peptide Fragments *Interferon-alpha. Peptides 2005 Jul;26(7):1144-9
DAI protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Tretinoin Interferon-alpha. Ann Oncol 2005 Feb;16(2):219-21
albuferon  0   *Serum Albumin *Interferon-alpha Hepatitis C. J Pharmacol Exp Ther 2002 Nov;303(2):540-8
Ifna9 protein, mouse  0   *Interferon-alpha. Immunol Cell Biol 2002 Oct;80(5):425-35
Ifna6 protein, mouse  0   *Interferon-alpha. Immunol Cell Biol 2002 Oct;80(5):425-35
IFNA17 protein, human  0   *Interferon-alpha. Cancer Lett. 2003 Jan 28;189(2):182-8
IFNA10 protein, human  0   *Interferon-alpha. Nature 1981 Mar 5;290(5801):20-6
CHVP regimen  0   Doxorubicin Teniposide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisone Interferon-alpha. Int J Hematol 2002 Jan 75(1):111-2
PIAF regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Fluorouracil Interferon-alpha. Semin Oncol 2001 Oct;28(5):514-20
peginterferon alfa-2b  0   *Polyethylene Glycols *Interferon-alpha Recombinant Proteins Drug Carriers Hepatitis C.
Pharma Action Antiviral Agents 		Gastroenterol Clin Biol 2000 Aug-Sep;24(8-9):767-9PEGINTRON; SYLATRON; PEGINTRON/REBETOL COMBO PACK
ROAD-IN protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Melphalan Nitrosourea Compounds Vincristine Interferon-alpha. Br J Haematol 2000 Jun;109(4):805-14
interferon alpha, HY-3  0   *Interferon-alpha Recombinant Fusion Proteins. J Immunol 1999 Jul 15;163(2):854-60
IFN-alpha21a(1-95), IFN-alpha2c(96-165) fusion protein  0   *Interferon-alpha Recombinant Fusion Proteins.
IFN-alpha21a(1-75), IFN-alpha2c(76-165) fusion protein  0   *Interferon-alpha Recombinant Fusion Proteins. J Immunol 1999 Jul 15;163(2):854-60
Rebetron  0   *Ribavirin *Interferon-alpha Drug Combinations Hepatitis C/drug therapy. FDA Consum 1999 Mar-Apr;33(2):23-9
interferon-alpha B-D  0   *Interferon-alpha Recombinant Proteins. Dig Dis Sci 1998 Aug;43(8);1719-24
PFLI-alpha protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Interferon-alpha Levoleucovorin. J Clin Oncol 1998 Aug;16(8):2715-21
interferon, alfa 2(125-129)  0   *Peptide Fragments *Interferon-alpha. Ross Fiziol Zh Im I M Sechenova 1997 Nov-Dec;83(11-12):19-29
peginterferon alfa-2a  0   *Polyethylene Glycols *Interferon-alpha Recombinant Proteins Drug Carriers.
Pharma Action Antiviral Agents 		Clin Pharmacol Ther 1996 Jun;59(6):636-46PEGINTERFERON; PEGASYS
peptide 2438  0   *Peptide Fragments *Interferon-alpha. Biochem Mol Biol Int 1994 Aug;33(5):969-79
cytoferon  0   *Cytokines *Interferon-alpha Drug Combinations. Ter Arkh 1993;65(11):67-70
interferon-alpha A-D  0   *Interferon-alpha Recombinant Fusion Proteins. Brain Behav Immun 1993 Mar;7(1):104-11
interferon-alpha 8  0   *Interferon-alpha. In Vivo 1992 Mar-Apr;6(2):145-50
interferon alpha 4A  0   *Interferon-alpha. Biochem Int 1990;22(6):1095
combiferon  0   *Interferon-alpha Drug Combinations Recombinant Proteins. Ter Arkh 1988;60(8):79
methionyl human consensus alpha interferon  0   *Interferon-alpha Recombinant Proteins. J Biol Response Mod 1988;7(3):240
interferon alfacon-1  118390-30-0   *Interferon-alpha Recombinant Proteins.
Pharma Action Antiviral Agents 		J Interferon Res 1986;6(4):405INFERGEN
interferon alpha 2, Ala(30,32,33)  0   *Interferon-alpha. Biochem Biophys Res Commun 1986;134(3):1412
interferon, alpha 1(111-166)  89789-11-7 L-Glutamic acid, L-leucyl-L-methionyl-L-asparaginyl-L-alanyl-L-alpha-aspartyl-L-seryl-L-isoleucyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-phenylalanyl-L-arginyl-L-arginyl-L-isoleucyl-L-threonyl-L-leucy(R)  *Peptide Fragments *Interferon-alpha. Eur J Biochem 1985;146(3):689
interferon, alpha 2(111-153)  0   *Peptide Fragments *Interferon-alpha. Proc Natl Acad Sci USA 1984;81(4):1045
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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