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Swainsonine

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Definition: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.     
Pharmacological Action Adjuvants, Immunologic; Antineoplastic Agents, Phytogenic; Enzyme Inhibitors 		Other names Swainsonine, (8a alpha)-Isomer; Swainsonine, (8 alpha,8a alpha)-Isomer; Swainsonine, (8 alpha)-Isomer; Swainsonine, (2 beta,8a alpha)-Isomer; Swainsonine, (1R-(2 beta,8a alpha))-Isomer
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
8-epi-swainsonine  0   Swainsonine/*analogs & derivatives Alkaloids. Org Lett. 2011 Dec 16;13(24):6452-5
swainsonine-human serum albumin conjugate  0   *Serum Albumin Swainsonine/*analogs & derivatives. Colloids Surf B Biointerfaces 2007 Jul 1;58(1):61-7
thioswainsonine  0   Swainsonine/*analogs & derivatives. Carbohydr Res 2006 Jul 24;341(10):1685-91
1,2-di-epi-swainsonine  0   Swainsonine/*analogs & derivatives Alkaloids. J Org Chem 2000 Sep 8;65(18):5693-706

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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