encyclopedia of medical concepts
ψ 

Protein Tyrosine Phosphatases

More information in Books or onNLM PubMed
Definition: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.  general; prefer specifics   
Examples Dual-Specificity Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Receptor-Like Protein Tyrosine Phosphatases; SH2 Domain-Containing Protein Tyrosine Phosphatases 		Other names Tyrosyl Phosphoprotein Phosphatase; Protein-Tyrosine-Phosphatase; Phosphotyrosine Phosphatase; Tyrosine Phosphatases, Protein; Protein Tyrosine Phosphatase; Protein Phosphatase, Phosphotyrosyl; Phosphoprotein Phosphatase, Tyrosyl; Phosphatases, Protein Tyrosine; Phosphatase, Tyrosyl Phosphoprotein; Phosphatase, Protein-Tyrosine; Phosphatase, Phosphotyrosyl Protein; Protein-Tyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Phosphatase, Phosphotyrosine; PTPase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MKP2 protein, Arabidopsis  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Arabidopsis Proteins. Plant Signal Behav 2010 Nov;5(11):1497-500
Ssu72 protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins. Biochem J 2011 Feb 24;434(3):435-44
tyrosine phosphatase inhibitor-3  0   *Thiazoles Protein Tyrosine Phosphatases/antagonists & inhibitors. Mol Cancer Ther 2010 Aug;9(8):2287-96
TULA-2 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Blood 2010 Oct 7;116(14):2570-8
Mop protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins. Proc Natl Acad Sci U S A 2010 May 4;107(18):8322-7
YGR203w protein, S cerevisiae  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Saccharomyces cerevisiae Proteins. Proteins 2009 Aug 1;76(2):520-4
PtpB protein, S cerevisiae  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Saccharomyces cerevisiae Proteins. Int J Biol Macromol 2009 Dec 1;45(5):463-9
chloro(diphenyl-2-pyridylphosphine)gold(I)  0   *Organogold Compounds Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6912-8
bis(4-trifluoromethyl-sulfonamidophenyl)-1,4-diisopropyl-benzene  0   *Sulfonamides Protein Tyrosine Phosphatases/antagonists & inhibitors. Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9
CDC14A protein, mouse  EC 3.1.3.-   *Protein Tyrosine Phosphatases. Cell Cycle 2009 Apr 1;8(7):1090-8
EYA3 protein, human  EC 3.1.3.48   *DNA-Binding Proteins *Protein Tyrosine Phosphatases. Nature. 2009 Apr 2;458(7238):591-6
EDTP protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins Egg Proteins. J Biochem 2005 Dec;138(6):721-8
PTPLA protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Int J Mol Med 2009 Feb;23(2):293-6
Ptpcd-1 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Cell Cycle Proteins. Biochem Biophys Res Commun 2009 Mar 13;380(3):460-6
PTPIP51 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Histochem Cell Biol 2008 Mar;129(3):345-56
phenylhydrazonopyrazolone sulfonate 1  0   *Benzenesulfonates *Hydrazones Protein Tyrosine Phosphatases/antagonists & inhibitors. Proc Natl Acad Sci U S A 2008 May 20;105(20):7275-80
Siw14 protein, S cerevisiae  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Saccharomyces cerevisiae Proteins. Genetics 2004 Feb;166(2):707-19
Ptp2 protein, S cerevisiae  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Saccharomyces cerevisiae Proteins. J Biol Chem 1992 May 15;267(14):10024-30
prostatic acid phosphatase (248-286), human  EC 3.1.3.2   *Peptide Fragments *Protein Tyrosine Phosphatases. Cell 2007 Dec 14;131(6):1059-71
EGG-3 protein, C elegans  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Caenorhabditis elegans Proteins. Curr Biol 2007 Sep 18;17(18):1545-54
PTPIP51 protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Histochem Cell Biol. 2007 Jul;128(1):77-84
PRL-3 protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Cancer Res 2006 Oct 1;66(19):9625-35
Pez protein, zebrafish  EC 3.1.3.-   *Protein Tyrosine Phosphatases *Zebrafish Proteins. J Cell Biol 2007 Sep 24;178(7):1223-35
MKP2 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Mol Endocrinol 1997 Jul;11(8):1129-44
eya3 protein, Xenopus  EC 3.1.3.48   *Trans-Activators *Protein Tyrosine Phosphatases *Xenopus Proteins. Dev Dyn. 2007 Jun;236(6):1526-34
CinnGEL 2Me  0   *Cinnamates *Oligopeptides Protein Tyrosine Phosphatases/antagonists & inhibitors. Mol Vis 2007;13:785-96
Ptp10D protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins. J Neurosci 2007 Apr 18;27(16):4396-402
FRIED protein, Xenopus  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Xenopus Proteins. Dev Dyn 2005 Sep;234(1):90-101
4-(O-nitrofurfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl))phenylacetyl-aspartyl-4-(O-nitrofurfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl))-N-(9-fluorenylmethoxycarbonyl)-phenylalanine amide  0   *Dipeptides *Organophosphorus Compounds Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2007 Feb 22;50(4):856-64
FAM82A2 protein, human  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Mitochondrial Proteins. Apoptosis. 2006 Sep;11(9):1489-501
UA 0713  0   *Triterpenes Phenylalanine/*analogs & derivatives Protein Tyrosine Phosphatases/antagonists & inhibitors. Biochim Biophys Acta 2006 Oct;1760(10):1505-12
PHS1 protein, Arabidopsis  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Arabidopsis Proteins. Plant Cell 2004 Jul;16(7):1841-53
brunsvicamide C  0   *Peptides, Cyclic Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2006 Aug 10;49(16):4871-8
brunsvicamide B  0   *Peptides, Cyclic Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2006 Aug 10;49(16):4871-8
brunsvicamide A  0   *Peptides, Cyclic Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2006 Aug 10;49(16):4871-8
EAK-6 protein, C elegans  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Caenorhabditis elegans Proteins. PLoS Genet 2006 Jul;2(7):e99
EAK-4 protein, C elegans  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Caenorhabditis elegans Proteins. PLoS Genet 2006 Jul;2(7):e99
7-bromo-6-difluoromethylphosphonate 3-naphthalenenitrile  0   *Nitriles *Phosphonic Acids Protein Tyrosine Phosphatases/antagonists & inhibitors. J Biol Chem 2006 Feb 24;281(8):5258-66
Stp1 protein, S pombe  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Schizosaccharomyces pombe Proteins. Int J Biochem Cell Biol 2006 Mar;38(3):444-60
Cdkn3 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Cyclin-Dependent Kinase Inhibitor Proteins. FASEB J 2006 Jan;20(1):43-9
eya-1 protein, C elegans  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Caenorhabditis elegans Proteins *Intracellular Signaling Peptides and Proteins. Dev Biol 2005 Oct 15;286(2):452-63
Eya2 protein, mouse  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Intracellular Signaling Peptides and Proteins.
eya1 protein, zebrafish  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Zebrafish Proteins *Intracellular Signaling Peptides and Proteins.
Eya1 protein, Xenopus  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Xenopus Proteins *Intracellular Signaling Peptides and Proteins.
Eya1 protein, mouse  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Intracellular Signaling Peptides and Proteins.
peroxyvanadate  0   *Vanadates Protein Tyrosine Phosphatases/antagonists & inhibitors. Ann Thorac Surg 2004 Aug;78(2):450-7
DDSP protein, human  EC 3.1.3.-   *Protein Tyrosine Phosphatases. Biochim Biophys Acta 2005 Apr 5;1728(1-2):84-94
CpsB protein, Streptococcus pneumoniae  EC 3.1.3.48   *Bacterial Proteins *Protein Tyrosine Phosphatases. J Med Microbiol 2005 Apr;54(Pt 4):351-6
EYA protein, Arabidopsis  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Arabidopsis Proteins. Biochemistry 2005 Jan 18;44(2):751-8
PTP-ER protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins.
ACP1 protein, human  EC 3.1.3.48   *Proto-Oncogene Proteins *Protein Tyrosine Phosphatases.
Acp1 protein, mouse  EC 3.1.3.48   *Proto-Oncogene Proteins *Protein Tyrosine Phosphatases.
Ptp4a1 protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Immediate-Early Proteins.
PTP4A1 protein, human  EC 3.1.3.48   *Membrane Proteins *Protein Tyrosine Phosphatases *Cell Cycle Proteins.
Sts-1 protein, human  EC 3.1.3.48   *Protein Tyrosine Phosphatases. J Biol Chem 2004 Jul 30;279(31):32786-95
PTP4A2 protein, human  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Genomics 1996 Jul 1;35(1):172-81
4-hydroxy-3,3-dimethyl-2H-benzo(g)indole-2,5(3H)-dione  0   *Indoles Protein Tyrosine Phosphatases/antagonists & inhibitors. J Pharmacol Exp Ther 2004 May;309(2):711-9
Pez protein, Drosophila  EC 3.1.3.48   *Cytoskeletal Proteins *Protein Tyrosine Phosphatases *Drosophila Proteins.
Ptpla protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases.
PTPLB protein, human  EC 4.2.1.-   *Membrane Proteins *Protein Tyrosine Phosphatases. Mol Cell Biol 2004 Apr;24(7):2767-78
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy