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Protein Tyrosine Phosphatases

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Definition: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.  general; prefer specifics   
Examples Dual-Specificity Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Receptor-Like Protein Tyrosine Phosphatases; SH2 Domain-Containing Protein Tyrosine Phosphatases
Other names Tyrosyl Phosphoprotein Phosphatase; Protein-Tyrosine-Phosphatase; Phosphotyrosine Phosphatase; Tyrosine Phosphatases, Protein; Protein Tyrosine Phosphatase; Protein Phosphatase, Phosphotyrosyl; Phosphoprotein Phosphatase, Tyrosyl; Phosphatases, Protein Tyrosine; Phosphatase, Tyrosyl Phosphoprotein; Phosphatase, Protein-Tyrosine; Phosphatase, Phosphotyrosyl Protein; Protein-Tyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Phosphatase, Phosphotyrosine; PTPase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MKP2 protein, Arabidopsis  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Arabidopsis Proteins. Plant Signal Behav 2010 Nov;5(11):1497-500
Ssu72 protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins. Biochem J 2011 Feb 24;434(3):435-44
tyrosine phosphatase inhibitor-3  0   *Thiazoles Protein Tyrosine Phosphatases/antagonists & inhibitors. Mol Cancer Ther 2010 Aug;9(8):2287-96
TULA-2 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Blood 2010 Oct 7;116(14):2570-8
Mop protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins. Proc Natl Acad Sci U S A 2010 May 4;107(18):8322-7
YGR203w protein, S cerevisiae  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Saccharomyces cerevisiae Proteins. Proteins 2009 Aug 1;76(2):520-4
PtpB protein, S cerevisiae  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Saccharomyces cerevisiae Proteins. Int J Biol Macromol 2009 Dec 1;45(5):463-9
chloro(diphenyl-2-pyridylphosphine)gold(I)  0   *Organogold Compounds Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6912-8
bis(4-trifluoromethyl-sulfonamidophenyl)-1,4-diisopropyl-benzene  0   *Sulfonamides Protein Tyrosine Phosphatases/antagonists & inhibitors. Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9
CDC14A protein, mouse  EC 3.1.3.-   *Protein Tyrosine Phosphatases. Cell Cycle 2009 Apr 1;8(7):1090-8
EYA3 protein, human  EC 3.1.3.48   *DNA-Binding Proteins *Protein Tyrosine Phosphatases. Nature. 2009 Apr 2;458(7238):591-6
EDTP protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins Egg Proteins. J Biochem 2005 Dec;138(6):721-8
PTPLA protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Int J Mol Med 2009 Feb;23(2):293-6
Ptpcd-1 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Cell Cycle Proteins. Biochem Biophys Res Commun 2009 Mar 13;380(3):460-6
PTPIP51 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Histochem Cell Biol 2008 Mar;129(3):345-56
phenylhydrazonopyrazolone sulfonate 1  0   *Benzenesulfonates *Hydrazones Protein Tyrosine Phosphatases/antagonists & inhibitors. Proc Natl Acad Sci U S A 2008 May 20;105(20):7275-80
Siw14 protein, S cerevisiae  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Saccharomyces cerevisiae Proteins. Genetics 2004 Feb;166(2):707-19
Ptp2 protein, S cerevisiae  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Saccharomyces cerevisiae Proteins. J Biol Chem 1992 May 15;267(14):10024-30
prostatic acid phosphatase (248-286), human  EC 3.1.3.2   *Peptide Fragments *Protein Tyrosine Phosphatases. Cell 2007 Dec 14;131(6):1059-71
EGG-3 protein, C elegans  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Caenorhabditis elegans Proteins. Curr Biol 2007 Sep 18;17(18):1545-54
PTPIP51 protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Histochem Cell Biol. 2007 Jul;128(1):77-84
PRL-3 protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Cancer Res 2006 Oct 1;66(19):9625-35
Pez protein, zebrafish  EC 3.1.3.-   *Protein Tyrosine Phosphatases *Zebrafish Proteins. J Cell Biol 2007 Sep 24;178(7):1223-35
MKP2 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Mol Endocrinol 1997 Jul;11(8):1129-44
eya3 protein, Xenopus  EC 3.1.3.48   *Trans-Activators *Protein Tyrosine Phosphatases *Xenopus Proteins. Dev Dyn. 2007 Jun;236(6):1526-34
CinnGEL 2Me  0   *Cinnamates *Oligopeptides Protein Tyrosine Phosphatases/antagonists & inhibitors. Mol Vis 2007;13:785-96
Ptp10D protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins. J Neurosci 2007 Apr 18;27(16):4396-402
FRIED protein, Xenopus  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Xenopus Proteins. Dev Dyn 2005 Sep;234(1):90-101
4-(O-nitrofurfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl))phenylacetyl-aspartyl-4-(O-nitrofurfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl))-N-(9-fluorenylmethoxycarbonyl)-phenylalanine amide  0   *Dipeptides *Organophosphorus Compounds Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2007 Feb 22;50(4):856-64
FAM82A2 protein, human  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Mitochondrial Proteins. Apoptosis. 2006 Sep;11(9):1489-501
UA 0713  0   *Triterpenes Phenylalanine/*analogs & derivatives Protein Tyrosine Phosphatases/antagonists & inhibitors. Biochim Biophys Acta 2006 Oct;1760(10):1505-12
PHS1 protein, Arabidopsis  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Arabidopsis Proteins. Plant Cell 2004 Jul;16(7):1841-53
brunsvicamide C  0   *Peptides, Cyclic Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2006 Aug 10;49(16):4871-8
brunsvicamide B  0   *Peptides, Cyclic Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2006 Aug 10;49(16):4871-8
brunsvicamide A  0   *Peptides, Cyclic Protein Tyrosine Phosphatases/antagonists & inhibitors. J Med Chem 2006 Aug 10;49(16):4871-8
EAK-6 protein, C elegans  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Caenorhabditis elegans Proteins. PLoS Genet 2006 Jul;2(7):e99
EAK-4 protein, C elegans  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Caenorhabditis elegans Proteins. PLoS Genet 2006 Jul;2(7):e99
7-bromo-6-difluoromethylphosphonate 3-naphthalenenitrile  0   *Nitriles *Phosphonic Acids Protein Tyrosine Phosphatases/antagonists & inhibitors. J Biol Chem 2006 Feb 24;281(8):5258-66
Stp1 protein, S pombe  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Schizosaccharomyces pombe Proteins. Int J Biochem Cell Biol 2006 Mar;38(3):444-60
Cdkn3 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Cyclin-Dependent Kinase Inhibitor Proteins. FASEB J 2006 Jan;20(1):43-9
eya-1 protein, C elegans  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Caenorhabditis elegans Proteins *Intracellular Signaling Peptides and Proteins. Dev Biol 2005 Oct 15;286(2):452-63
Eya2 protein, mouse  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Intracellular Signaling Peptides and Proteins.
eya1 protein, zebrafish  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Zebrafish Proteins *Intracellular Signaling Peptides and Proteins.
Eya1 protein, Xenopus  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Xenopus Proteins *Intracellular Signaling Peptides and Proteins.
Eya1 protein, mouse  EC 3.1.3.48   *Nuclear Proteins *Protein Tyrosine Phosphatases *Intracellular Signaling Peptides and Proteins.
peroxyvanadate  0   *Vanadates Protein Tyrosine Phosphatases/antagonists & inhibitors. Ann Thorac Surg 2004 Aug;78(2):450-7
DDSP protein, human  EC 3.1.3.-   *Protein Tyrosine Phosphatases. Biochim Biophys Acta 2005 Apr 5;1728(1-2):84-94
CpsB protein, Streptococcus pneumoniae  EC 3.1.3.48   *Bacterial Proteins *Protein Tyrosine Phosphatases. J Med Microbiol 2005 Apr;54(Pt 4):351-6
EYA protein, Arabidopsis  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Arabidopsis Proteins. Biochemistry 2005 Jan 18;44(2):751-8
PTP-ER protein, Drosophila  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Drosophila Proteins.
ACP1 protein, human  EC 3.1.3.48   *Proto-Oncogene Proteins *Protein Tyrosine Phosphatases.
Acp1 protein, mouse  EC 3.1.3.48   *Proto-Oncogene Proteins *Protein Tyrosine Phosphatases.
Ptp4a1 protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Immediate-Early Proteins.
PTP4A1 protein, human  EC 3.1.3.48   *Membrane Proteins *Protein Tyrosine Phosphatases *Cell Cycle Proteins.
Sts-1 protein, human  EC 3.1.3.48   *Protein Tyrosine Phosphatases. J Biol Chem 2004 Jul 30;279(31):32786-95
PTP4A2 protein, human  EC 3.1.3.48   *Protein Tyrosine Phosphatases. Genomics 1996 Jul 1;35(1):172-81
4-hydroxy-3,3-dimethyl-2H-benzo(g)indole-2,5(3H)-dione  0   *Indoles Protein Tyrosine Phosphatases/antagonists & inhibitors. J Pharmacol Exp Ther 2004 May;309(2):711-9
Pez protein, Drosophila  EC 3.1.3.48   *Cytoskeletal Proteins *Protein Tyrosine Phosphatases *Drosophila Proteins.
Ptpla protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases.
PTPLB protein, human  EC 4.2.1.-   *Membrane Proteins *Protein Tyrosine Phosphatases. Mol Cell Biol 2004 Apr;24(7):2767-78
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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