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Glycosylation End Products, Advanced

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Definition: Products derived from the nonenzymatic reaction of glucose and proteins in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of diabetes mellitus.  DF: GEPA    Other names Glycation End Products, Advanced; Advanced Glycosylation End Products; Advanced Glycation End Products
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
glucosepane  0   *Glycosylation End Products, Advanced. Rejuvenation Res 2009 Apr;12(2):137-48
N(omega)-carboxymethylarginine  0   Arginine/*analogs & derivatives Biological Markers Glycosylation End Products, Advanced. Biochem J 2000 Apr 1;347 Pt 1:23-7
N(2)-(1-carboxymethyl)guanine  0   Guanine/*analogs & derivatives Glycosylation End Products, Advanced. Bioorg Med Chem Lett 1998 Aug 18;8(16):2109-10
advanced glycation end products-human serum albumin  0   *Serum Albumin *Glycosylation End Products, Advanced. Arterioscler Thromb Vasc Biol 1997 Nov;17(11):2885-90
carboxymethylethanolamine  0   *Ethanolamines Biological Markers Glycosylation End Products, Advanced. J Biol Chem 1997 Jul 11;272(28):17473-9
OPB 9195  0   *Thiadiazoles *Thiazolidines Glycosylation End Products, Advanced/antagonists & inhibitors. Diabetes 1997 May;46(5):895-9
2-benzamido-5--(5-((2,3,4-trihydroxybutyl)-4-oxoimidazol-2-yl)amino)pentanamide  0   *Imidazoles Arginine/*analogs & derivatives Glycosylation End Products, Advanced. J Clin Invest 1997 Mar 15;99(6):1272-80
2-benzamido-5-(5-((2,3,4-trihydroxybutyl)-4-oxo-2-imidazolin-2-yl)amino)pentanamide  0   *Imidazoles Arginine/*analogs & derivatives Glycosylation End Products, Advanced. J Clin Invest 1997 Mar 15;99(6):1272-80
advanced glycation end products-bovine serum albumin  0   *Serum Albumin, Bovine *Glycosylation End Products, Advanced. Biochem Biophys Res Commun 1993 Jun 15;193(2):674-80
advanced glycosylation end-product receptor  0   *Receptors, Immunologic Glycosylation End Products, Advanced. Blood Purif 1990;8(4):223
pentosidine  124505-87-9 4H-Imidazo(4,5-b)pyridine-4-hexanoic acid, alpha-amino-2-((4-amino-4-carboxybutyl)amino)-, (S-(R*,R*))  Arginine/*analogs & derivatives Lysine/*analogs & derivatives Glycosylation End Products, Advanced.
Pharma Action Cross-Linking Reagents 		J Biol Chem 1989;264(36):21597
2-formyl-5-(hydroxymethyl)pyrrole-1-norleucine  74509-14-1   *Pyrroles Norleucine/*analogs & derivatives Glycosylation End Products, Advanced. J Chromatogr 1989;463(1):119
N(6)-carboxymethyllysine  5746-04-3   Lysine/*analogs & derivatives Glycosylation End Products, Advanced. J Biol Chem 1986;261(11):4889

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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