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Complement Factor H

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Definition: An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).     
Pharmacological Action Complement Inactivating Agents 		Other names Factor H; Factor H, Complement
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
complement factor H, human  0   Complement Factor H.
adrenomedullin-binding protein 1, human  0   *Complement Factor H. J Biol Chem 2001 Apr 13;276(15):12292-300. Epub 2000 Dec 14.
adrenomedullin-binding protein 1, rat  0   *Complement Factor H. Endocrinology 1999 Oct;140(10):4908-11
bladder tumor-associated antigen  0   *Antigens, Neoplasm *Tumor Markers, Biological Complement Factor H. Int J Biol Markers 1997 Oct-Dec;12(4):174-80
CFHR3 protein, human  0   *Blood Proteins Plasma Complement Factor H. Dev Comp Immunol 1996 Nov-Dec;20(6):407-16
cofactor-related protein 1, sand bass  0   *Blood Proteins Bass Plasma Complement Factor H. Dev Comp Immunol 1996 Nov-Dec;20(6):407-16
factor H-related protein 2  0   *Blood Proteins Plasma Complement Factor H. J Biol Chem 1996 Jul 26;271(30):18054-60
factor H-related protein 1  0   *Blood Proteins Plasma Complement Factor H. J Biol Chem 1996 Jul 26;271(30):18054-60

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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