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Complement Factor I

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Definition: A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.  do not confuse with FACTOR I see FIBRINOGEN   
Pharmacological Action Complement Inactivating Agents 		Other names Inactivator, Complement C4b-C3b; Inactivator, C3b-C4b; Inactivator, C3b; Complement C4b C3b Inactivator; Complement 3b Complement 4b Inactivator; C4b-C3b Inactivator, Complement; C4b C3b INA; C3b C4b Inactivator; Complement C4b-C3b Inactivator; Complement 3b-Complement 4b Inactivator; C4bC3bINA; C4b-C3b-INA; C3b-C4b Inactivator; C3b Inactivator
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CFI protein, human  EC 3.4.21.45   *Complement Factor I.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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