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Antigens, CD3

More information in Books or onNLM PubMed
Definition: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).  T-lymphocyte differentiation antigens   
See Also Receptors, Antigen, T-Cell
Examples Receptor-CD3 Complex, Antigen, T-Cell 		Other names T3 Antigens; CD3 Complex; CD3 Antigens; Antigens, T3; Antigen, T3; Antigen, CD3; T3 Complex; T3 Antigen; CD3 Antigen
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Cd3e protein, mouse  0   *Antigens, CD3. Mol Immunol 2004 Apr;40(18):1295-305
CD3delta antigen  0   *Antigens, CD3. Proc Natl Acad Sci U S A 1986 May;83(9):2944-8
visilizumab  219716-33-3   *Antibodies, Monoclonal, Humanized Antigens, CD3. Blood 2002 Apr 15;99(8):2712-9
CD3 antigen, gamma chain  0   *Antigens, CD3. Eur J Immunol 2002 Mar;32(3):616-26
CD3 antigen, zeta chain  0   *Antigens, CD3. Cytogenet Cell Genet 1999;85(3-4):301-5
CD3E protein, human  0   *Antigens, CD3 Receptors, Antigen, T-Cell Signal Transduction. J Immunol 1998 Nov 1;161(9):4591-8
CD3fos-F(ab')2  0   *Immunoglobulin Fragments Antigens, CD3. J Exp Med 1998 Apr 20;187(8):1249-60
tumor-associated antigen GA733  0   *Antigens, Neoplasm *Cell Adhesion Molecules Tumor Markers, Biological Antigens, CD3. Curr Top Microbiol Immunol 2000 ;251:109-17; Proc Natl Acad Sci USA 1989;86(1):27

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