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Photosensitizing Agents

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Definition: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.  note entry term PHOTOSENSITIZING EFFECT: use only for the photosensitizing effect of a chemical substance   
See Also Hematoporphyrin Photoradiation; PUVA Therapy; Photochemotherapy 		Other names Photosensitizers; Effects, Photosensitizing; Effect, Photosensitizing; Agents, Photosensitizing; Photosensitizing Effects; Photosensitizing Effect
Substances having this pharmacologic action: carprofen; aminomethyltrioxsalen; terthienyl; tetra(4-N-methylpyridyl)porphine; 5-methoxypsoralen; protoporphyrin IX; deuteroporphyrin-IX; gilvocarcin V; afloqualone; acetophenone; polymyxin B nonapeptide; merocyanine dye; titanium dioxide; Psoralens; Riboflavin; Dihematoporphyrin Ether; Hematoporphyrin Derivative; Trioxsalen; Methoxsalen; Hematoporphyrins; Ficusin; Aminolevulinic Acid; 1,9-dimethylmethylene blue; motexafin gadolinium; methyl 5-aminolevulinate; benzoporphyrin D; verteporfin; motexafin lutetium; silicon phthalocyanine; temoporfin; tin etiopurpurin; aluminum phthalocyanine disulfonate; hypocrellin B; Talaporfin; benzophenone; hypocrellin A; Zn(II)-phthalocyanine; bis(tri-n-hexylsiloxy)(2,3-naphthalocyaninato)silicon; chloroaluminum tetrasulfophthalocyanine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
magnesium 5,10,15,20-tetrakis(4-sulphophenyl)-porphine dodecahydrate  0   *Metalloporphyrins Photosensitizing Agents. Toxicol In Vitro. 2011 Sep;25(6):1169-72
PYROA protein, Emericella nidulans  0   *Fungal Proteins Photosensitizing Agents. J Biol Chem 1999 Aug 13;274(33):23565-9
photosan III  136219-06-2   *Hematoporphyrins Photosensitizing Agents. J Photochem Photobiol B 1991;10(1-2):111
lomefloxacin  98079-51-7 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride  *Fluoroquinolones Antitubercular Agents Photosensitizing Agents.
Pharma Action Anti-Infective Agents 		Antimicrob Agents Chemother 1987;31(6):854MAXAQUIN
cyamemazine  3546-03-0   *Phenothiazines Antipsychotic Agents Anti-Anxiety Agents Photosensitizing Agents. Lancet 1981;1(8216):386; Therapie 30(2):267;1975
tiaprofenic acid  33005-95-7 5-benzoyl-alpha-methyl-2-thiopheneacetic acid  *Propionic Acids Prostaglandin Antagonists Photosensitizing Agents.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal 		Chir Den Fr 46:105;1976; J Pharm Sci 66(7):1030;1977; J Steroid Biochem 10(4):471;1979; Phlebologie 29(1):69;1976; Rev Odontostomatol (Paris) 4(6):535;1975; Rev Odontostomatol 5(5):395;1976; Rheumatol Rehabil 1979;18(4):257

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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