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Serotonin Uptake Inhibitors

More information in Books or onNLM PubMed
Definition: Compounds that specifically inhibit the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. These agents have been used in treatment of depression, panic disorder, obsessive-compulsive behavior, and alcoholism, as analgesics, and to treat obesity and bulimia. Many of the ADRENERGIC UPTAKE INHIBITORS also inhibit serotonin uptake; they are not included here.  general or unspecified; prefer specifics; do not confuse with SEROTONIN ANTAGONISTS   
See Also Adrenergic Uptake Inhibitors; Antidepressive Agents, Second-Generation 		Other names Serotonin Reuptake Inhibitors; 5-Hydroxytryptamine Uptake Inhibitors; 5-HT Uptake Inhibitors; Uptake Inhibitors, 5 Hydroxytryptamine; Uptake Inhibitors, 5 HT; Inhibitors, 5 Hydroxytryptamine Uptake; Inhibitors, 5 HT Uptake; 5 Hydroxytryptamine Uptake Inhibitors; 5 HT Uptake Inhibitors; Uptake Inhibitors, Serotonin; Uptake Inhibitors, 5-Hydroxytryptamine; Uptake Inhibitors, 5-HT; Selective Serotonin Reuptake Inhibitors; Reuptake Inhibitors, Serotonin; Inhibitors, Serotonin Uptake; Inhibitors, Serotonin Reuptake; Inhibitors, 5-Hydroxytryptamine Uptake; Inhibitors, 5-HT Uptake
Substances having this pharmacologic action: femoxetine; indalpine; alaproclate; Sertraline; Clomipramine; Fluvoxamine; Paroxetine; Zimeldine; Citalopram; Trazodone; Norfenfluramine; Fluoxetine; Amoxapine; Fenfluramine; olanzapine; duloxetine; milnacipran; venlafaxine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DA 8031  0   *Benzofurans Serotonin Uptake Inhibitors. Urology 2011 Apr;77(4):1006.e17-21
dapoxetine  119356-77-3   *Benzylamines *Naphthalenes Serotonin Uptake Inhibitors. J Chromatogr 1993 Feb 26;612(2):253-61

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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