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Protein Prenylation

More information in Books or onNLM PubMed
Definition: A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.      Other names Protein Isoprenylation; Post-Translational Isoprenylation; Prenylation, Protein; Polyisoprenylation, Protein; Geranylgeranylation, Protein; Farnesylation, Protein; Protein Polyisoprenylation; Protein Geranylgeranylation; Protein Farnesylation
 
SubstanceCAS Registry & nameCategoriesSource
ptb1 protein, S pombe  0   *Alkyl and Aryl Transferases *Schizosaccharomyces pombe Proteins Protein Prenylation.
N-(4-(1-cyclohexyl-3-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl)methionine  0   Methionine/*analogs & derivatives Protein Prenylation. J Med Chem 1999 Nov 18;42(23):4844-52
BZA 5B  0   *Benzodiazepines *Oligopeptides Protein Prenylation. J Biol Chem 1994 Nov 4;269(44):27705-14
geranylgeranyltransferase type-I  EC 2.5.1.-   *Alkyl and Aryl Transferases Diterpenes Protein Prenylation. Proc Natl Acad Sci U S A 1993 Sep 15;90(18):8557-61
CHM protein, human  0   *Adaptor Proteins, Signal Transducing Protein Prenylation rab GTP-Binding Proteins.
Pharma Action GTP Phosphohydrolase Activators 		Cell 1993 Jun 18;73(6):1091-9
p21(ras) farnesyl-protein transferase  EC 2.5.1.-   *Alkyl and Aryl Transferases Protein Prenylation. Cell 1990;62(1):81

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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