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Receptors, Dopamine D1

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Definition: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D1-class receptor genes lack INTRONS, and the receptors stimulate ADENYLATE CYCLASE.  DF: RECEPT DOPAMINE D1   
Examples Receptors, Dopamine D5 		Other names Receptor, Dopamine-D1; Dopamine D1 Receptor; D1 Receptors, Dopamine; Dopamine-D1 Receptor; Dopamine D1 Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno(3,4-c)isoquinoline  0   *Phenanthridines Receptors, Dopamine D1/agonists. J Med Chem 2006 Nov 16;49(23):6848-57
7-methyl-2,3-dimethoxy-5,6,7,8,9,14-hexahydrodibenz(d,g)azecine  0   *Heterocyclic Compounds, 3-Ring Receptors, Dopamine D1/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):760-9
Dop1 protein, Drosophila  0   *Receptors, Dopamine D1 *Drosophila Proteins. Arch Insect Biochem Physiol 2005 Jul;59(3):118-31
Dop-1 protein, C elegans  0   *Receptors, Dopamine D1 *Caenorhabditis elegans Proteins. EMBO J 2004 Jan 28;23(2):473-82
5-brom-3-(ortho-chlorphenyl)-1-(4-(4-phenyl-1-piperazinyl)butyl)indazole  0   *Indazoles Ligands Receptors, Dopamine D1. Pharmazie 1999 Feb;54(2):99-101
NNC 22-0215  0   *Benzazepines *Benzofurans Ligands Receptors, Dopamine D1. Nucl Med Biol 1998 Jul;25(5):503-8
SDZ GLC 756  0   *Quinolines Ophthalmic Solutions Receptors, Dopamine D1/antagonists & inhibitors Receptors, Dopamine D2/agonists. Jpn J Ophthalmol 1996;40(2):167-73
dopamine D1C receptor  0   *Receptors, Dopamine D1. Biochim Biophys Acta 1996 Jul 31;1308(1):17-22
dopamine D1A receptor  0   *Receptors, Dopamine D1. J Med Chem 1996 Feb 16;39(4):850-9
YM 435  138086-00-7   *Tetrahydroisoquinolines Receptors, Dopamine D1/agonists. Chem Pharm Bull (Tokyo) 1991 Nov;39(11):2910-4
dihydrexidine  123039-93-0 Benzo(a)phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, trans  *Phenanthridines Receptors, Dopamine D1/agonists.
Pharma Action Dopamine Agonists 		Eur J Pharmacol 1989;166(1):111
pramipexol  104632-26-0 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (S)  *Benzothiazoles Restless Legs Syndrome Receptors, Dopamine D1/agonists Receptors, Dopamine D2/agonists.
Pharma Action Antioxidants ; Antiparkinson Agents ; Dopamine Agonists 		Naunyn Schmiedebergs Arch Pharmacol 1989;340(1):21MIRAPEX; PRAMIPEXOLE DIHYDROCHLORIDE; MIRAPEX ER

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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