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Receptors, Dopamine D2

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Definition: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.  DF: RECEPT DOPAMINE D2   
Examples Receptors, Dopamine D3; Receptors, Dopamine D4 		Other names Receptor, Dopamine-D2; Dopamine D2 Receptor; D2 Receptors, Dopamine; Dopamine-D2 Receptor; Dopamine D2 Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate  0   *Aporphines Thioctic Acid/*analogs & derivatives Receptors, Dopamine D2/agonists Serotonin 5-HT1 Receptor Agonists. J Med Chem 2011 Jul 14;54(13):4324-38
7-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one  0   *Piperazines *Quinolones Receptors, Dopamine D2/agonists Receptors, Dopamine D3/agonists. Bioorg Med Chem 2011 Jun 1;19(11):3502-11
7-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one  0   *Piperazines *Quinolones Receptors, Dopamine D2/agonists Receptors, Dopamine D3/agonists. Bioorg Med Chem 2011 Jun 1;19(11):3502-11
1H-indole-2-carboxylic acid (4-(2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl)cyclohexyl)amide  0   *Indoles *Isoquinolines Receptors, Dopamine D2/antagonists & inhibitors Receptors, Dopamine D3/antagonists & inhibitors. Mol Pharmacol 2010 Nov;78(5):925-34
2-chloro-N-n-propylnorapomorphine  0   Apomorphine/*analogs & derivatives Carbon Radioisotopes Ligands Receptors, Dopamine D2/agonists. Nucl Med Biol 2010 Jan;37(1):35-40
7-(4-(3-(1H-inden-3-yl)propyl)piperazin-1-yl)-1,3-benzoxazol-2(3H)-one  0   *Benzoxazoles *Indenes Receptors, Dopamine D2/agonists. J Pharmacol Exp Ther 2010 Jan;332(1):190-201
2,10,11-trihydroxy-N-propylnorapomorphine  0   Apomorphine/*analogs & derivatives Receptors, Dopamine D2/agonists. Eur J Pain 2008 Jul;12(5):535-43
N-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl)-1-cyclohexylmethyl)-2,3-bicyclo(2.2.1)heptanedicarboximide  0   *Thiazoles *Isoindoles Receptors, Dopamine D2/antagonists & inhibitors Receptor, Serotonin, 5-HT2A/antagonists & inhibitors. Eur J Pharmacol 2007 Oct 31;572(2-3):160-70LATUDA
YKP 1358  0   *Alkaloids Receptors, Dopamine D2/antagonists & inhibitors Receptor, Serotonin, 5-HT2A/antagonists & inhibitors. Clin Pharmacol Ther 2007 Feb;81(2):252-8
N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine  0   *Benzofurans *Benzylamines Receptors, Dopamine D2/antagonists & inhibitors Receptor, Serotonin, 5-HT1A/agonists. J Med Chem 2007 Feb 22;50(4):865-76
8-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazin-1-yl)-4H-benzo(1,4)oxazin-2-methyl-3-one  0   *Indoles *Benzoxazines Receptors, Dopamine D2/antagonists & inhibitors. J Med Chem 2005 Nov 3;48(22):6855-69
DOP-4 protein, C elegans  0   *Receptors, Dopamine D2 *Caenorhabditis elegans Proteins. J Neurochem 2005 Aug;94(4):1146-57
N-methyl-N-n-propyl-2-amino-5-fluoro-6-hydroxy-1-phenyl-2,3-dihydro-1H-indene  0   *Indenes Receptors, Dopamine D2/agonists. J Med Chem 2005 Apr 7;48(7):2646-54
N-methyl-N-n-propyl-2-amino-6-fluoro-5-methoxy-1-phenyl-2,3-dihydro-1H-indene  0   *Indenes Receptors, Dopamine D2/agonists. J Med Chem 2005 Apr 7;48(7):2646-54
DOP-3 protein, C elegans  0   *Receptors, Dopamine D2 *Caenorhabditis elegans Proteins. Nat Neurosci 2004 Oct;7(10):1096-103
5-hydroxy-2-(N-propyl-N-(5'-fluoropentyl))aminotetralin  0   *Tetrahydronaphthalenes Fluorine Radioisotopes Receptors, Dopamine D2 Receptors, Dopamine D2/agonists. Nucl Med Biol 2004 Apr;31(3):303-11
3-(3-(methylsulfonyl)phenyl)-1-propylpiperidine  0   *Piperidines *Sulfones Receptors, Dopamine D2/antagonists & inhibitors. J Clin Pharmacol 2004 Mar;44(3):276-83
9-(4-methylpiperazin-1-yl)pyrrolo(2,1-b)benzothiazepine  0   *Pyrroles *Thiazepines Receptors, Dopamine D2/antagonists & inhibitors Receptor, Serotonin, 5-HT2A/antagonists & inhibitors. J Med Chem 2004 Jan 1;47(1):143-57
S 32504  0   *Oxazines Receptors, Dopamine D2/agonists. J Neurochem 2003 Nov;87(3):631-41
dop-2 protein, C elegans  0   *Receptors, Dopamine D2 *Caenorhabditis elegans Proteins. J Neurochem 2003 Aug;86(4):869-78
dopamine D2 receptor alpha1B  0   *Receptors, Dopamine D2. J Pharmacol Exp Ther 2003 Jan;304(1):380-90
DD2R protein, Drosophila  0   *Receptors, Dopamine D2 *Drosophila Proteins. Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14554-9
5-bromo-N-(1-ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridinecarboxamide 2-fumarate  0   *Azepines *Pyridines Receptors, Dopamine D2/antagonists & inhibitors. Br J Pharmacol 2001 May;133(2):253-60
2-amino-2,3,3a,4,5,6-hexahydro-1H-phenalene  0   *Amines *Phenalenes Receptors, Dopamine D2/antagonists & inhibitors. Farmaco 2000 Sep-Oct;55(9-10):575-82
10,11-dihydroxy-N-n-propylnorapomorphine  0   Apomorphine/*analogs & derivatives Receptors, Dopamine D2/agonists. J Neurochem 2001 Apr;77(2):493-504
1-((3-methylphenyl)piperazin-1-yl)-3-(thio(4-acetamido)phenyl)propane  0   *Piperazines Propane/*analogs & derivatives Receptors, Dopamine D2. Spectrochim Acta A Mol Biomol Spectrosc 2000 Jun;56A(7):1267-75
1-((2-phenylcyclopropyl)-methyl)-4-(2,4-dimethylphenyl)piperazine  0   *Piperazines Receptors, Dopamine D2/antagonists & inhibitors. J Med Chem 2000 Oct 19;43(21):3923-32
1-((2-phenylcyclopropyl)methyl)-4-(2,4-dichlorophenyl)piperazine  0   *Piperazines Receptors, Dopamine D2/antagonists & inhibitors. J Med Chem 2000 Oct 19;43(21):3923-32
2-((benzyl)propylamino)-5-methoxytetralin  0   *Tetrahydronaphthalenes Receptors, Dopamine D2/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Aug 2;9(15):2167-72
sibenadet  0   *Thiazoles Receptors, Dopamine D2/agonists Receptors, Adrenergic, beta-2/agonists. J Med Chem 1998 Dec 3;41(25):4915-7
3-(4-(2-(2-chlorophenyl)ethyl)-1-piperazinyl)-4,5-dihydro-1H-benzo(g)indazole  0   *Indazoles Receptors, Dopamine D2. Bioorg Med Chem 1998 Jun;6(6):743-53
dopamine D2L receptor  0   *Receptors, Dopamine D2. Biochem Pharmacol 1998 Jul 1;56(1):25-30
CHF 1024  0   *Tetrahydronaphthalenes Receptors, Dopamine D2/agonists. J Cardiovasc Pharmacol 1998 Apr;31(4):601-8
1-methyl-3-(2-(4-(3-methoxyphenyl)butyl)phenoxymethyl)piperidine  0   *Piperidines Receptors, Dopamine D2/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1998 Apr;46(4):639-46
1-ethyl-3-(2-(4-(3-methoxyphenyl)butyl)phenoxymethyl)piperidine  0   *Piperidines Receptors, Dopamine D2/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1998 Apr;46(4):639-46
1-methyl-3-(2-(4-phenylbutyl)phenoxymethyl)piperidine  0   *Piperidines Receptors, Dopamine D2/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1998 Apr;46(4):639-46
GR 103691  0   *Biphenyl Compounds *Piperazines Receptors, Dopamine D2/antagonists & inhibitors. Eur J Pharmacol 1996 Dec 30;318(2-3):283-93
SDZ GLC 756  0   *Quinolines Ophthalmic Solutions Receptors, Dopamine D1/antagonists & inhibitors Receptors, Dopamine D2/agonists. Jpn J Ophthalmol 1996;40(2):167-73
pramipexol  104632-26-0 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (S)  *Benzothiazoles Restless Legs Syndrome Receptors, Dopamine D1/agonists Receptors, Dopamine D2/agonists.
Pharma Action Antioxidants ; Antiparkinson Agents ; Dopamine Agonists 		Naunyn Schmiedebergs Arch Pharmacol 1989;340(1):21MIRAPEX; PRAMIPEXOLE DIHYDROCHLORIDE; MIRAPEX ER
apomorphine receptor  0   *Receptors, Opioid *Receptors, Dopamine D2 Apomorphine. Life Sci 1981;29(2):121
N-n-propylnorapomorphine  58479-52-0   Apomorphine/*analogs & derivatives Carbon Radioisotopes Radioactive Tracers Receptors, Dopamine D2/agonists.
Pharma Action Antiparkinson Agents ; Dopamine Agonists 		Arch Int Pharmacodyn Ther 1979;242(2):241; Arch Neurol 35(12):787;1978; Exp Neurol 55(1):56;1977; Experientia 34(11):1490;1978; J Med Chem 16(11):1223;1973; Lancet 1(7963):786;1976; N Engl J Med 294(11):567;1976; Nature 259(5544):584;1976; Pharmacol Biochem Behav 1979;11(6):653

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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