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Receptors, Opioid, delta

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Definition: A class of opioid receptors recognized by its pharmacological profile. Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins.  opioid receptors; DF: RECEPT DELTA    Other names delta Receptors; Receptors, delta Opioid; Receptors, delta; Opioid Receptors, delta; delta Opioid Receptors; Receptor, delta Opioid; Receptor, delta; Opioid Receptor, delta; delta Receptor; delta Opioid Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
17-cyclopropylmethyl-6,7-didehydro-quinolino(2',3'-6,7)morphinan-4-ol  0   *Morphinans *Quinolines Receptors, Opioid, delta/agonists. Bioorg Med Chem. 2012 Jan 15;20(2):949-61.
6,7-didehydro-17-methyl-quinolino(2',3'-6,7)morphinan-4-ol  0   *Morphinans *Quinolines Receptors, Opioid, delta/agonists. Bioorg Med Chem. 2012 Jan 15;20(2):949-61.
6,7-didehydro-17-isobutyl-quinolino(2',3'-6,7)morphinan-4-ol  0   *Morphinans *Quinolines Receptors, Opioid, delta/agonists. Bioorg Med Chem. 2012 Jan 15;20(2):949-61.
tyrosyl-phenylalanyl-glycyl-tryptophyl-N-methylnorleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Cholecystokinin/antagonists & inhibitors Receptors, Opioid, delta/agonists. Life Sci. 2003 Jun 27;73(6):699-704.
Dmt-NMe-Ala-Aba-Gly-NH2  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem. 2011 Nov 24;54(22):7848-59.
SDM 25N  0   Naltrexone/*analogs & derivatives Receptors, Opioid, delta/antagonists & inhibitors. J Neurosci 2011 Sep 21;31(38):13346-56
4-((3-aminophenyl)(4-(4-fluorobenzyl)piperazin-1-yl)methyl)-N,N-diethylbenzamide  0   *Benzamides *Piperazines Receptors, Opioid, delta/agonists. J Pharmacol Exp Ther 2011 Jul;338(1):195-204
eribis peptide 94  0   *Enkephalins Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. Eur J Pharmacol 2011 Jan 25;651(1-3):146-51
N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide  0   *Piperidines *Benzamides Receptors, Opioid, delta/agonists. Chemistry. 2010 Nov 2;16(41):12342-8
KNT 127  0   *Morphinans Receptors, Opioid, delta/agonists. Bioorg Med Chem Lett 2010 Nov 1;20(21):6302-5
2',6'-dimethyl-4'-(N-((4'-phenyl)phenethyl)carboxamido)phenylalanine-tetrahydroisoquinoline-3-carboxylic acid- phenylalanyl-phenylalanine  0   *Oligopeptides Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6941-5
4'-(N-((4'-phenyl)phenethyl)carboxamido)phenylalanyl-tetrahydroisoquinoline-3-carboxylic acid- phenylalanyl-phenylalanine  0   *Oligopeptides Receptors, Opioid, delta/agonists. J Med Chem 2009 Nov 12;52(21):6941-5
N,N-diethyl-3-hydroxy-4-(spiro(chromene-2,4'-piperidine)-4-yl)benzamide  0   *Benzopyrans *Spiro Compounds Receptors, Opioid, delta/agonists. J Med Chem 2009 Sep 24;52(18):5685-702
RTI 5989-25  0   *Piperidines Receptors, Opioid, delta/antagonists & inhibitors. Br J Pharmacol. 2009 Apr;156(7):1044-53
9-(8-azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide  0   *Xanthenes *Azabicyclo Compounds Receptors, Opioid, delta/agonists. J Pharmacol Exp Ther 2009 Apr;329(1):241-51
17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5',6'-dihydro-3-methoxy-4'H-pyrrolo(3,2,1-ij)quinolino(2',1'-6,7)morphinan-14-ol  0   Naltrexone/*analogs & derivatives Receptors, Opioid, delta/antagonists & inhibitors. Bioorg Med Chem 2008 Sep 1;16(17):7956-67
17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-8'-fluoro-5',6'-dihydro-4'H-pyrrolo(3,2,1-ij)quinolino(2',1'-6,7)morphinan-3,14-diol  0   Naltrexone/*analogs & derivatives Receptors, Opioid, delta/antagonists & inhibitors. Bioorg Med Chem 2008 Sep 1;16(17):7956-67
N,N-diethyl-4-(5-hydroxyspiro(chromene-2,4'-piperidine)-4-yl)benzamide  0   *Benzamides *Benzopyrans Receptors, Opioid, delta. J Med Chem 2008 Oct 9;51(19):5893-6
OPRD1 protein, human  0   *Receptors, Opioid, delta. Mol Psychiatry. 2008 May;13(5):531-43
2',6'-dimethyltyrosyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (1H-benzimidazol-2-yl)(carboxymethyl)methylamide  0   *Benzimidazoles *Oligopeptides Receptors, Opioid, delta/agonists. Br J Pharmacol 2007 Dec;152(8):1312-24
9-hydroxy-5-(3-hydroxyphenyl)-2-phenylethyl-2-azabicyclo(3.3.1)nonane  0   *Bicyclo Compounds, Heterocyclic Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2007 Aug 9;50(16):3765-76
tyrosyl-alanyl-glycyl-phenylalanyl-norleucyl-prolyl-leucyl-tryptophyl-O-3,5-benzyl(CF3)2  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists Receptors, Neurokinin-1/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2779-86
tyrosyl-alanyl-glycyl-phenylalanyl-methionyl-prolyl-leucyl-tryptophyl-O-3,5-benzyl(CF3)2  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists Receptors, Neurokinin-1/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2779-86
tyrosyl-cyclo(allylglycyl-phenylalanyl-allylglycyl)amide  0   *Peptides, Cyclic Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem 2007 Mar 22;50(6):1414-7
2',6'-dimethyltyrosyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-beta-methylcyclohexylalanyl-phenylalanine  0   *Oligopeptides Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2007 Jan 25;50(2):328-33
N-(5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo(3.3.1)non-7-yl)-2-methyl-2-phenylpropanamide  0   *Bicyclo Compounds, Heterocyclic Receptors, Opioid, delta/agonists. J Med Chem 2006 Sep 7;49(18):5597-609
N,N-diethyl-4-((8-phenethyl-8-azabicyclo(3.2.1)oct-3-ylidene)phenylmethyl)benzamide  0   *Bicyclo Compounds, Heterocyclic Receptors, Opioid, delta/agonists. J Pharmacol Exp Ther 2006 Sep;318(3):1273-9
2',6'-dimethyltyrosyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-glutamamide  0   *Oligopeptides Receptors, Opioid, delta/agonists. J Med Chem 2006 Jun 15;49(12):3653-8
tyrosyl-norleucyl-glycyl-tryptophyl-norleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Cholecystokinin/antagonists & inhibitors Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem 2006 May 18;49(10):2868-75
tyrosyl-alanyl-glycyl-tryptophyl-N-methylnorleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem 2006 May 18;49(10):2868-75
4-(4-((4-diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic acid  0   *Piperazines *Benzoic Acids Receptors, Opioid, delta/agonists. J Pharmacol Exp Ther 2006 Jan;316(1):423-30
3,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone  0   *Peptides *Pyrazines Receptors, Opioid, mu/antagonists & inhibitors Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2005 Dec 15;48(25):8035-44
1,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane  0   *Diamines *Peptides Receptors, Opioid, mu/antagonists & inhibitors Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2005 Dec 15;48(25):8035-44
2',6'-dimethyltyrosyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 1H-benzimidazol-2-ylmethylamide  0   *Benzimidazoles *Dipeptides Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2005 Dec 29;48(26):8112-4
4-(alpha-(2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide  0   *Benzhydryl Compounds *Piperazines Receptors, Opioid, delta/agonists. J Pharmacol Exp Ther 2005 Nov;315(2):601-8
2',6'-dimethyltyrosyl-1,2,3,4-tetrahydroisoquinolinecarbonyl-phenylalanyl-(N(epsilon)-benzyloxycarbonyl)lysine  0   *Oligopeptides Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2005 Aug 25;48(17):5608-11
N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide  0   *Dipeptides Receptors, Opioid, delta/antagonists & inhibitors Receptors, Opioid, delta/agonists. J Pharmacol Exp Ther 2005 Apr;313(1):410-21
KDAN 18  0   *Amides Naltrexone/*analogs & derivatives Receptors, Opioid, delta/agonists Receptors, Opioid, kappa/agonists. J Med Chem 2005 Mar 24;48(6):1713-6
17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-4'-phenyl-6,7-2',3'-pyrrolomorphinan  0   *Morphinans Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2004 Dec 16;47(26):6645-8
N(1)-(2',6'-dimethyltyrosyl-arginyl-phenylalanyl-lysyl)-N(2)-(tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-psi(CH2NH)-cyclohexylalanyl-phenylalanyl)ethylenediamine  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Pept Res 2004 Feb;63(2):63-8
5'-(4-chlorophenyl)-6,7-didehydro-4,5alpha-epoxy-3-hydroxy-17-methylpyrido(2',3'-6,7)morphinan  0   *Morphinans Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2004 Mar 11;47(6):1400-12
5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo(3.3.1)non-7-yl-(1-phenyl-1-cyclopentane)carboxamide  0   *Bicyclo Compounds, Heterocyclic Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2004 Jan 15;47(2):281-4
3-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(4-fluorophenyl)-N-methylbenzamide  0   *Benzamides *Piperazines Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem 2003 Feb 13;46(4):623-33
DOR-1 protein, mouse  0   *Receptors, Opioid, delta. J Neurosci 2002 Dec 15;22(24):10906-13
oprd1 protein, zebrafish  0   *Receptors, Opioid, delta *Zebrafish Proteins. Protein Eng 2001 Dec;14(12):953-60
2',6'-dimethyltyrosyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid  0   *Dipeptides *Tetrahydroisoquinolines Ligands Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2002 Jan 31;45(3):713-20
2',6'-dimethyltyrosyl-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-glycine N-benzylamide  0   *Oligopeptides *Tetrahydroisoquinolines Ligands Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2002 Jan 31;45(3):713-20
SB 235863A  0   *Morphine Derivatives Narcotics Receptors, Opioid, delta. Cardiovasc Drugs Ther 2001 Jan;15(1):89-90
rubiscolin 6  0   *Peptide Fragments *Ribulose-Bisphosphate Carboxylase Receptors, Opioid, delta/agonists. FEBS Lett 2001 Dec 7;509(2):2113-7
rubiscolin 5  0   *Peptide Fragments *Ribulose-Bisphosphate Carboxylase Receptors, Opioid, delta/agonists. FEBS Lett 2001 Dec 7;509(2):213-7
2,3-bis(benzoyloxy)tartaric acid  2743-38-6   *Tartrates Receptors, Opioid, delta/agonists. Eur J Pharmacol 2001 Apr 20;418(1-2):79-87
SoRI 9409  0   *Morphine Derivatives Receptors, Opioid, delta. J Pharmacol Exp Ther 2001 May;297(2)0:597-605
SB 219825  0   *Indoles *Isoquinolines Ligands Receptors, Opioid, delta/agonists. Brain Res Mol Brain Res 2000 Sep 15;80(2):166-76
SB 222941  0   *Heterocyclic Compounds with 4 or More Rings Ligands Receptors, Opioid, delta/agonists. Brain Res Mol Brain Res 2000 Sep 15;80(2):166-76
SB 213698  0   *Isoquinolines *Quinolines Ligands Receptors, Opioid, delta/agonists. Brain Res Mol Brain Res 2000 Sep 15;80(2):166-76
SB 206848  0   *Indoles *Isoquinolines Ligands Receptors, Opioid, delta/agonists. Brain Res Mol Brain Res 2000 Sep 15;80(2):166-76
N,N(Me)2-dimethyl-tyrosine-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-OH  0   *Tetrahydroisoquinolines Tyrosine/*analogs & derivatives Receptors, Opioid, delta/antagonists & inhibitors. Neuroreport. 2000 Jul 14;11(10):2083-6
N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide  0   *Benzamides *Piperidines Receptors, Opioid, delta/agonists. J Med Chem 2000 Oct 19;43(21):3895-905
N,N-diethyl-4-(1-piperazinyl(8-quinolinyl)methyl)benzamide  0   *Piperazines *Quinolines Receptors, Opioid, delta/agonists. J Med Chem 2000 Oct 19;43(21):3878-94
cyclo(prolyl-1-naphthylalanyl-tryptophyl-tyrosyl-threonyl-phenylalanyl)  0   *Peptides, Cyclic Receptors, Opioid, mu/antagonists & inhibitors Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2000 Feb 24;43(4):551-9
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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