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Receptors, Endothelin

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Definition: Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.  DF: RECEPT ENDOTHELIN   
Examples Receptor, Endothelin A; Receptor, Endothelin B 		Other names Receptors, Endothelium-Derived Vasoconstrictor Fac; Endothelin Receptors; Receptors, Endothelium Derived Vasoconstrictor Fac; Receptor, Endothelin; Receptors, Endothelins; Endothelium Derived Vasoconstrictor Factor Recepto; Endothelin Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-cyano-3,3-diphenylpropionic acid  0   *Phenylpropionates *Pyrimidines Receptors, Endothelin/antagonists & inhibitors. Bioorg Med Chem Lett 2011 Jul 1;21(13):3894-7
Ednrb2 protein, Xenopus  0   *Receptors, Endothelin *Xenopus Proteins. Dev Dyn 2011 Jun;240(6):1454-66
Dear1 protein, mouse  0   *Receptors, Angiotensin *Receptors, Endothelin. Physiol Genomics 2005 Nov 17;23(3):257-68
SPP301  0   *Pyridines *Pyrimidines Receptors, Endothelin/antagonists & inhibitors. J Clin Pharmacol 2004 Jan;44(1):59-66
Pael-R protein, Drosophila  0   *Receptors, Endothelin *Drosophila Proteins. Neuron 2003 Mar 27;37(6):911-24
N-((2'-(((4,5-dimethyl-3-isoxazolyl)amino)sulfonyl)-4-(2-oxazolyl)(1,1'-biphenyl)-2-yl)methyl)-N,3,3-trimethylbutanamide  0   *Oxazoles *Sulfonamides Receptors, Endothelin/antagonists & inhibitors. J Med Chem 2003 Jan 2;46(1):125-37
N-(6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl)-2-phenylethenesulfonamide  0   *Pyrimidines *Sulfonamides Receptors, Endothelin/antagonists & inhibitors. Bioorg Med Chem 2001 Nov;9(11):2955-68
2-(3-fluoro-4-methylphenyl)-4-(2,3-dihydrobenzofuran-5-yl)-1-(N,N-dibutylaminocarbonylmethyl)pyrrolidine-3-carboxylic acid  0   *Benzofurans *Pyrrolidines Receptors, Endothelin/antagonists & inhibitors. J Med Chem 2001 Nov 8;44(23):3978-84
N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide  0   *Pyrimidines *Sulfonamides Receptors, Endothelin/antagonists & inhibitors. J Med Chem 2001 Oct 11;44(21):3355-68
2-(benzo(1,3)dioxo-5-yl)-6-isopropyl-4-(4-methoxyphenyl)-2H-chromene-3-carboxylic acid  0   *Benzopyrans Receptors, Endothelin/antagonists & inhibitors. J Cardiovasc Pharmacol 2001 Apr;37(4):471-82
J-105859  0   *Alkanes *Pyridines Receptors, Endothelin/antagonists & inhibitors. J Hypertens. 2000 Dec;18(12):1815-23
ZD 2574  0   *Sulfonamides *Pyrazines Receptors, Endothelin/antagonists & inhibitors. J Pharmacol Exp Ther 2000 Nov;295(2):578-85
BMS 193884  0   *Oxazoles *Sulfonamides Receptors, Endothelin/antagonists & inhibitors. J Med Chem 2000 Aug 10;43(16):3111-7
2-(2-cyano-5-(pyrid-4-yl)methoxy)phenoxy-2-(2-methyl)phenylacetic acid  0   *Phenylacetates *Pyridines Receptors, Endothelin/antagonists & inhibitors. J Med Chem 2000 Mar 9;43(5):900-10
cyclo(tryptophyl-aspartyl-prolyl-isoleucyl-leucyl)  0   *Peptides, Cyclic Receptors, Endothelin/antagonists & inhibitors. J Mass Spectrom 2000 Feb;35(2):265-76
BSF 302146  0   *Benzhydryl Compounds *Pyrimidines Receptors, Endothelin/antagonists & inhibitors. Trends Pharmacol Sci 2000 Feb;21(2):38-40
ATZ1993  0   *Indazoles Receptors, Endothelin/antagonists & inhibitors. Jpn J Pharmacol 1999 Sep;81(1):21-8
TBC 2576  0   *Sulfonamides *Thiophenes Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4485-9
97-618 compound  0   *Sulfonamides Receptors, Endothelin/antagonists & inhibitors. Eur J Pharmacol 1999 Sep 17;381(1):39-49
ZD 1611  0   *Pyrazines Sulfonamides Receptors, Endothelin/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Sep;290(3):1085-91
lysyl-arginyl-12-aminodecanoyl-seryl-prolyl-phenylalanine  0   *Oligopeptides Receptors, Endothelin/agonists. J Med Chem 1999 Aug 26;42(17):3369-77
tezosentan  0   *Pyridines *Tetrazoles Receptors, Endothelin.
Pharma Action Vasodilator Agents 		J Pharmacol Exp Ther 1999 Aug;290(2):840-6VELETRI
A 192621  0   *Pyrrolidines Receptors, Endothelin. Pulm Pharmacol Ther 1999;12(1):13-26
3-(5-(4-benzo(1,3)dioxol-5-yl-2-hydroxy-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3-ylmethyl)-2,3-dimethoxyphenoxy)propane-1-sulfonic acid  0   *Benzenesulfonates *Dioxoles Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1999 Jun 17;42(12):2162-8
J 104132  0   *Pyridines Receptors, Endothelin/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Jun;289(3):1262-70
Ro 48-5695  0   *Sulfonamides Receptors, Endothelin/antagonists & inhibitors. Circulation 1999 Apr 6;99(13):1747-52
IRL 3461  0   *Dipeptides Receptors, Endothelin/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Aug 18;8(16):2241-6
PD 161721  0   *Dioxins Receptors, Endothelin/antagonists & inhibitors. Cardiovasc Res 1998 Sep;39(3):625-32
BMS 187308  0   *Isoxazoles *Sulfonamides Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1998 Dec 17;41(26):5198-218
PD 164800  0   *Dioxoles *Thiazines Receptors, Endothelin/antagonists & inhibitors. Bioorg Med Chem 1998 Sep;6(9):1447-56
A 216546  0   *Pyrrolidines Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1998 Aug 13;41(17):3261-75
T 0201  0   *Pyrimidines *Sulfonamides Receptors, Endothelin/antagonists & inhibitors. J Pharmacol Exp Ther 1998 Aug;286(2):643-9
RPR 111723  0   *Phenylpropionates Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1998 Jul 16;41(15):2745-53
4-(2-cyano-5-(3-pyridylmethoxy)phenoxy)-4-(2-methylphenyl)butanoic acid  0   *Phenylbutyrates *Pyridines Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1998 Jul 16;41(15):2732-44
SB 247083  0   *Benzofurans *Propionic Acids Receptors, Endothelin/antagonists & inhibitors. J Cardiovasc Pharmacol 1998;31 Suppl 1:S273-6
LU 224332  0   *Propionic Acids *Pyrimidines Stereoisomerism Receptors, Endothelin/antagonists & inhibitors. J Cardiovasc Pharmacol 1998;31 Suppl 1:S241-4
endothelin-1, Cys(Acm)(1,15)-Ala(3)-Leu(7)-Aib(11)  0   Endothelin-1/*analogs & derivatives Receptors, Endothelin/agonists. FEBS Lett 1998 Mar 27;425(2):234-8
PD 164333  0   *Crotonic Acids *Dioxoles Receptors, Endothelin/antagonists & inhibitors. Br J Pharmacol 1998 Jan;123(2):223-230
TTA 386  0   *Oligopeptides Receptors, Endothelin/antagonists & inhibitors. Neuropeptides 1997 Aug;31(4):345-9
LU 135252  0   *Phenylpropionates *Pyrimidines Receptors, Endothelin/antagonists & inhibitors. Br J Pharmacol 1997;121(5):935-40
endothelin-1, Thr(18)-Leu(19)  0   Endothelin-1/*analogs & derivatives Receptors, Endothelin/antagonists & inhibitors. Eur J Pharmacol 1997 May 1;325(2-3):263-70
endothelin-1, Thr(18)-Cha(19)  0   Endothelin-1/*analogs & derivatives Receptors, Endothelin/antagonists & inhibitors. Eur J Pharmacol 1997 May 1;325(2-3):263-70
PD 156252  0   *Oligopeptides Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1997 Jul 4;40(14):2228-40
sitaxsentan  0   *Isoxazoles *Thiophenes Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1997 May 23;40(11):1690-7
BQ 238  0   *Peptides, Cyclic Receptors, Endothelin/antagonists & inhibitors. Br J Pharmacol 1997 Jan;120(2):319-25
BQ 928  166735-10-0   *Oligopeptides *Piperidines Receptors, Endothelin/antagonists & inhibitors. Br J Pharmacol 1997 Jan;120(2):319-25
L 744453  0   *Dioxoles *Imidazoles Receptors, Endothelin/antagonists & inhibitors. Life Sci 1996;58(14):1149-57
IRL 1720  0   *Peptide Fragments *Endothelins Receptors, Endothelin/agonists. Eur J Pharmacol 1996 Jan 18;296(1):55-63
endothelin-3 receptor  0   *Receptors, Endothelin. Biochem Biophys Res Commun 1996 Mar 27;220(3):839-42
A 127722  0   *Pyrrolidines Carbon Radioisotopes Stereoisomerism Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1996 Mar 1;39(5):1039-48
SB 217242  0   *Carboxylic Acids *Indans Receptors, Endothelin/antagonists & inhibitors. J Cardiovasc Pharmacol 1995;26 Suppl 3:S404-7
RES 701-4  0   *Peptides, Cyclic Receptors, Endothelin/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Nov;48(11):1213-20
RES 701-3  0   *Peptides, Cyclic Receptors, Endothelin/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Nov;48(11):1213-20
RES 701-2  0   *Peptides, Cyclic Receptors, Endothelin/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Nov;48(11):1213-20
RES 1214-2  0   *Hydroxybenzoic Acids *Phenyl Ethers Receptors, Endothelin/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Dec;48(12):1401-6
RES 1214-1  0   *Hydroxybenzoic Acids *Phenyl Ethers Receptors, Endothelin/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Dec;48(12):1401-6
stachybocin C  0   *Benzofurans *Spiro Compounds Receptors, Endothelin/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Dec;48(12):1396-400
stachybocin B  0   *Benzofurans *Spiro Compounds Receptors, Endothelin/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Dec;48(12):1396-400
stachybocin A  0   *Benzofurans *Spiro Compounds Receptors, Endothelin/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Dec;48(12):1396-400
CGS 27830  155485-56-6   *Dihydropyridines Receptors, Endothelin/antagonists & inhibitors. J Pharmacol Exp Ther 1996 Jan;276(1):74-83
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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