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Receptors, Opioid, kappa

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Definition: A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.  opioid receptors found in the anterior pituitary & substantia nigra; DF: RECEPT KAPPA    Other names kappa Receptors; Receptors, kappa Opioid; Receptors, kappa; Opioid Receptors, kappa; kappa Opioid Receptors; Receptor, kappa Opioid; Receptor, kappa; Opioid Receptor, kappa; kappa Receptor; kappa Opioid Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-naphthoyl-beta-naltrexamine  0   Naltrexone/*analogs & derivatives Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. J Med Chem. 2012 Jan 26;55(2):
3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide  0   *Benzamides *Pyrrolidines Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem. 2011 Dec 8;54(23):8000-12.
3-chloro-4-(4-((2-(3-pyridyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide  0   *Benzamides *Pyrrolidines Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem. 2011 Dec 8;54(23):8000-12.
2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine  0   *Biphenyl Compounds *Sulfonamides Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem. 2011 Aug 25;54(16):5868-77.
KNT 42  0   *Bridged Compounds Receptors, Opioid, kappa/agonists. Bioorg Med Chem Lett 2011 Jul 1;21(13):4104-7
3-N-ethylaminothiazolo(5,4-b)-N-cyclopropylmethylmorphinan hydrochloride  0   *Morphinans Receptors, Opioid, kappa/agonists. Acta Pharmacol Sin. 2010 Dec;31(12):1547-52
2-(2'-amino-3-methylbutanoate)salvinorin B  0   *Diterpenes, Clerodane Valine/*analogs & derivatives Receptors, Opioid, kappa/agonists. Bioorg Med Chem Lett 2011 Jan 1;21(1):160-3
6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid-(1-(4-(3-hydroxyphenyl)dimethylpiperidinylmethyl)methylpropyl)amide  0   *Piperidines *Tetrahydronaphthalenes Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2010 Jul 22;53(14):5290-301
N-(1-((4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylpropyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide  0   *Piperidines *Tetrahydroisoquinolines Receptors, Opioid, kappa/antagonists & inhibitors. Psychopharmacology (Berl) 2010 Jun;210(2):189-98
N-(1-((4-(3-carbamoylphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylpropyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide  0   *Piperidines *Tetrahydroisoquinolines Receptors, Opioid, kappa/antagonists & inhibitors. Psychopharmacology (Berl) 2010 Jun;210(2):189-98
7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylbutyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride  0   *Piperidines *Tetrahydroisoquinolines Receptors, Opioid, kappa/antagonists & inhibitors. Psychopharmacology (Berl) 2010 Jun;210(2):189-98
methyl 8-(2-(3,4-dichlorophenyl)acetyl)-2-(pyrrolidin-1-yl)-6,8-diazabicyclo(3.2.2)nonane-6-carboxylate  0   *Azabicyclo Compounds Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2010 May 27;53(10):4212-22
phenylethyl orvinol  0   *Morphinans Carbon Radioisotopes Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. J Med Chem 2009 Sep 24;52(18):5586-9
CJ 15,208  0   *Peptides, Cyclic Receptors, Opioid, kappa/antagonists & inhibitors. Adv Exp Med Biol 2009;611:269-70
1-(N-cyclobutylmethylmorphinan-3-yl)-10-(N-cyclobutylmethylmorphinan-3-yl)sebacolyate  0   *Morphinans Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. Neurochem Res 2008 Oct;33(10):2142-50
methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate  0   *Secologanin Tryptamine Alkaloids Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. Neuropharmacology 2008 Aug;55(2):154-65
Ro1 protein, mouse  0   *Receptors, Opioid, kappa. Nat Biotechnol 1999 Feb;17(2):165-9
bis(N-cyclobutylmethylmorphinan-3-yl) sebacoylate dihydrochloride  0   *Alkanes *Morphinans Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/antagonists & inhibitors Receptors, Opioid, kappa/agonists. Pharmacology. 2008;81(3):229-35
OPRK1 protein, human  0   *Receptors, Opioid, kappa. Mol Psychiatry 2006 Nov;11(11):1016-24
OR3 protein, zebrafish  0   *Receptors, Opioid, kappa *Zebrafish Proteins. Neurosci Lett. 2006 Sep 11;405(1-2):94-9
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(5-(3-hydroxyphenyl)-4-methyl-2-(2-(2-methylphenyl)ethyl)-2-azabicyclo(3.3.1)non-7-yl)propanamide  0   *Bicyclo Compounds, Heterocyclic Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2006 Mar 9;49(5):1781-91
bis(N-cyclobutylmethylmorphinan)fumarate  0   *Fumarates *Morphinans Receptors, Opioid, mu/antagonists & inhibitors Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. J Pharmacol Exp Ther 2005 Nov;315(2):821-7
dynorphin A-(1-11)-NH2, Nalpha-benzylTyr(1)-cyclo(Asp(5)-Dap(8))  0   *Dynorphins *Peptide Fragments Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2005 Jul 14;48(14):4500-3
KDAN 18  0   *Amides Naltrexone/*analogs & derivatives Receptors, Opioid, delta/agonists Receptors, Opioid, kappa/agonists. J Med Chem 2005 Mar 24;48(6):1713-6
17,17'-bis(cyclopropylmethyl)-6,6',7,7'-tetrahydro-4,5-4',5'-diepoxy-6,6'-(benzylimino)(7,7'-bimorphinan)-3,3',14,14'-tetrol  0   Naltrexone/*analogs & derivatives Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2005 Mar 10;48(5):1676-9
phenylalanyl-phenylalanyl-norleucyl-argininamide  0   *Oligopeptides Receptors, Opioid, kappa/agonists. J Pharmacol Exp Ther 2004 Jul;310(1):326-33
17-(cyclopropylmethyl)-4-hydroxy-14-((3-phenylpropyl)oxy)morphinan-6-one  0   *Morphinans Receptors, Opioid, kappa/agonists. J Med Chem 2004 Jun 3;47(12):3242-7
1-(4-butyl-2-(1-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)-2-(3.,4-dichlorophenyl)ethan-1-one  0   *Piperazines *Pyrrolidines Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2001 Aug 16;44(17):2814-26
7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide  0   *Piperidines *Tetrahydroisoquinolines Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2001 Aug 16;44(17):2687-90
N-((1-(6-amidinobutylhexylcarbamoyl)-3-methyl-1-butylcarbamoyl)methyl)-1-phenyl-2-((8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methanobenzazocin-3-yl)methyl)cyclopropanecarboxamide  0   *Azocines *Cyclopropanes Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2000 Aug 10;43(16):2992-3004
N-((1-(5-amidinobutylpentylcarbamoyl)-3-methyl-1-butylcarbamoyl)methyl)-1-phenyl-2-((8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methanobenzazocin-3-yl)methyl)cyclopropanecarboxamide  0   *Azocines *Cyclopropanes Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2000 Aug 10;43(16):2992-3004
17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5'-guanidinyl-3,14-dihydroxyindolo(2',3'-6,7)morphinan  0   *Guanidines *Morphinans Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2000 Jul 13;43(14):2759-69
JVA 901  0   *Oligopeptides Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 1999 Aug 12;42(16):3011-3
kappa(1) opioid receptor  0   *Receptors, Opioid, kappa. J Pharm Pharmacol 1998 Oct;50(10):1121-5
RTI 5989-29  0   *Piperidines Ligands Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 1998 Dec 17;41(26):5188-97
CNGN-TI compound  0   Naltrexone/*analogs & derivatives Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 1998 Dec 3;41(25):4911-4
GNTI compound  0   Naltrexone/*analogs & derivatives Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 1998 Dec 3;41(25):4911-4
TRK 820  0   *Morphinans *Spiro Compounds Receptors, Opioid, kappa/agonists. Chem Pharm Bull (Tokyo) 1998 Feb;46(2):366-9
Ro2 protein, recombinant  0   *Recombinant Fusion Proteins *Receptors, Opioid, kappa. Proc Natl Acad Sci U S A 1998 Jan 6;95(1):352-7
Ro1 protein, synthetic  0   *Receptors, Opioid, kappa. Proc Natl Acad Sci U S A 1998 Jan 6;95(1):352-7
kappa(2) opioid receptor  0   *Receptors, Opioid, kappa. J Neurosci 1997 Nov 1;17(21):8225-33
niravoline  130610-93-4   *Pyrrolidines *Benzeneacetamides Receptors, Opioid, kappa/agonists. J Pharmacol Exp Ther 1996 Jul;278(1):232-42
BRL 53117  157000-71-0   *Piperidines *Pyrrolidines Stereoisomerism Receptors, Opioid, kappa/agonists. J Pharmacol Exp Ther 1994 Jul;270(1):244-9
fedotozine  123618-00-8 Benzenemethanamine, alpha-ethyl-N,N-dimethyl-alpha-(((3,4,5-trimethoxyphenyl)methoxy)methyl)-, (R)  *Benzyl Compounds *Propylamines Receptors, Opioid, kappa/agonists. J Pharm Pharmacol 1990;42(8):546
enadoline  107431-28-7   *Benzofurans *Pyrrolidines Receptors, Opioid, kappa/agonists.
Pharma Action Anti-Arrhythmia Agents ; Neuroprotective Agents 		Br J Pharmazol 1990;101(1):183
spiradoline  87151-85-7   *Pyrrolidines Receptors, Opioid, kappa/agonists.
Pharma Action Analgesics ; Anti-Arrhythmia Agents ; Diuretics 		J Pharmacol Exp Ther 1987;240(1):128
U 69593  96744-75-1 Benzeneacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, (5alpha,7alpha,8beta)-(-)  *Benzeneacetamides *Pyrrolidines Receptors, Opioid, kappa/agonists.
Pharma Action Analgesics ; Diuretics 		Eur J Pharmacol 1985;109(2):281

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