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Receptors, Platelet-Derived Growth Factor

More information in Books or onNLM PubMed
Definition: Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA) and the beta PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA) are the two principle types of PDGF receptors. Activation of the protein-tyrosine kinase activity of the receptors occurs by ligand-induced dimerization or heterodimerization of PDGF receptor types.  DF: RECEPT PDGF   
See Also Platelet-Derived Growth Factor
Examples Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta 		Other names Receptors, PDGF; Platelet-Derived Growth Factor Receptors; PDGF Receptors; Receptors, Platelet Derived Growth Factor; Receptor, PDGF; Platelet Derived Growth Factor Receptors; Platelet Derived Growth Factor Receptor; Platelet-Derived Growth Factor Receptor; PDGF Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TAK 593  0   *Pyrazoles *Azabicyclo Compounds Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Biochemistry 2011 Feb 8;50(5):738-51
PDGFRL protein, human  0   *Receptors, Platelet-Derived Growth Factor *Tumor Suppressor Proteins. World J Gastroenterol 2010 Mar 28;16(12):1465-72
N-(4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-N'-(2-methylbenzoyl)thiourea  0   *Quinolines Thiourea/*analogs & derivatives Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors. J Med Chem 2006 Apr 6;49(7):2186-92
(6,7-dimethoxy-2,4-dihydroindeno(1,2-c)pyrazol-3-yl)(3-fluorophenyl)amine  0   *Indans *Pyrazoles Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors. Mol Cancer Ther 2005 Aug;4(8):1198-204
THRX 165724  0   *Pyrroles *Indoles Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors. Proc Natl Acad Sci U S A 2003 Jun 24;100(13):7830-5
Pvr protein, Drosophila  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases *Drosophila Proteins Receptors, Platelet-Derived Growth Factor Receptors, Vascular Endothelial Growth Factor. Cell 2001 Oct 5;107(1):17-26
Ki 6896  0   *Quinolines Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors. Gen Pharmacol 1998 Nov;31(5);765-73
6,7-dimethoxy-3-phenylquinoxaline  146535-11-7   *Tyrphostins Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Biochemistry 1997 May 27;36(21):6260-9
PDGF receptor tyrosine kinase  EC 2.7.1.-   *Receptors, Platelet-Derived Growth Factor. J Med Chem 1996 May 24;39(11):2170-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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