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Receptors, Somatostatin

More information in Books or onNLM PubMed
Definition: Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter.  DF: RECEPT SRIH   
See Also Somatostatin 		Other names Somatostatin Receptors; Receptors, Somatotropin Release Inhibiting Hormone; Receptor, Somatostatin; Somatostatin Receptor; SRIH Receptors; Receptors, SRIH
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
somatostatin receptor 1, mouse  0   *Receptors, Somatostatin. BMC Neurosci. 2011;12() (dup#71); 89
somatostatin receptor 2, mouse  0   *Receptors, Somatostatin. BMC Neurosci. 2011;12() (dup#71); 89
111In-DOTA-p-nitrophenylalanyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-threonyl-cysteinyl)tyrosinamide  0   *Peptides, Cyclic *Coordination Complexes Indium Radioisotopes Receptors, Somatostatin/antagonists & inhibitors. J Nucl Med 2011 Sep;52(9):1412-7
4-((4-fluorobenzyl)oxy)-1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyridin-2(1H)-one  0   *Pyridones Receptors, Somatostatin/antagonists & inhibitors. Bioorg Med Chem. 2011 Jan 15;19(2):883-93
L-264,930  0   *Spiro Compounds Receptors, Somatostatin/agonists. Tanpakushitsu Kakusan Koso 2007 Oct;52(13 Suppl):1810-1
somatostatin, des-amino acid(1,2,5)-Glu(7)-Trp(8)-IAmp(9)-m-I-Tyr(11)-hhLys(12)  0   Somatostatin/*analogs & derivatives Receptors, Somatostatin/agonists. J Med Chem 2005 Jan 27;48(2):515-22
Sstr2 protein, mouse  0   *Receptors, Somatostatin.
Mch1r protein, mouse  0   *Receptors, Somatostatin.
Mch1r protein, rat  0   *Receptors, Somatostatin.
BIM 23454  0   *Peptides Receptors, Somatostatin/antagonists & inhibitors. Endocrinology 2002 Apr;143(4):1218-24
BIM 23627  0   *Peptides Receptors, Somatostatin/antagonists & inhibitors. Endocrinology 2002 Apr;143(4):1218-24
BN 81674  0   *Carbolines Receptors, Somatostatin/antagonists & inhibitors. J Med Chem 2001 Aug 30;44(18):2990-3000
L803087  0   *Amides *Indoles Receptors, Somatostatin/agonists. J Physiol Paris 2000 May-Aug;94(3-4):211-5
L796778  0   *Amides *Nitrobenzenes Receptors, Somatostatin/agonists. J Physiol Paris 2000 May-Aug;94(3-4):211-5
L797591  0   *Naphthalenes *Pyridines Receptors, Somatostatin/agonists. J Physiol Paris 2000 May-Aug;94(3-4):211-5
H(2)N-(Phe)-cyclo(Cys-Phe-(Trp)-Lys-Thr-Cys)-Thr-OH  0   *Peptides, Cyclic Receptors, Somatostatin. Bioconjug Chem 2001 Jan-Feb;12(1):44-50
BIM-23244  0   *Receptors, Somatostatin. J Clin Endocrinol Metab 2001 Jan;86(1):140-5
CYN 154806  0   *Oligopeptides Stereoisomerism Receptors, Somatostatin/antagonists & inhibitors. Mol Pharmacol 1996 Oct;50(4):709-15
NeoTect  0   *Peptides Receptors, Somatostatin. J Natl Cancer Inst 1999 Oct 6;91(19):1607
L 779976  0   *Amides *Indoles Somatostatin/agonists Receptors, Somatostatin/agonists. Science 1998 Oct 29;282(5389):737-40
L 817818  0   *Amides *Naphthalenes Somatostatin/agonists Receptors, Somatostatin/agonists. Science 1998 Oct 29;282(5389):737-40
PRL 2903  0   *Peptides, Cyclic Receptors, Somatostatin/antagonists & inhibitors. Life Sci 1999;65(10):PL115-20
PRL 2915  0   *Peptides, Cyclic Receptors, Somatostatin/antagonists & inhibitors. J Med Chem 1999 Jun 3;42(11):1863-71
PRL 2970  0   *Peptides, Cyclic Receptors, Somatostatin/antagonists & inhibitors. J Med Chem 1999 Jun 3;42(11):1863-71
Sstr2 protein, rat  0   *Receptors, Somatostatin. Br J Pharmacol 1998 Sep;125(1):209-17
AC 178335  0   *Oligopeptides Receptors, Somatostatin/antagonists & inhibitors. Mol Pharmacol 1998 Nov;54(5):864-73
L 54264  0   *Indoles *Piperidines Receptors, Somatostatin/agonists. J Med Chem 1998 Jun 18;41(13):2175-9
somatostatin receptor sst2A  0   *Receptors, Somatostatin. Endocrinology 1997 Jun;138(6):2632-5
somatostatin receptor 3  0   *Receptors, Somatostatin. Ann N Y Acad Sci 1996 Dec 26;805:601-6
MCHR1 protein, human  0   *Receptors, Somatostatin Heterotrimeric GTP-Binding Proteins. FEBS Lett 1996 Dec 2;398(2-3):253-8
somatostatin receptor type 1  0   *Receptors, Somatostatin. J Biol Chem 1996 Aug 23;271(34):20331-9
somatostatin receptor subtype-4  0   *Receptors, Somatostatin. Gene 1996 Feb 12;168(2):233-5
somatostatin receptor 5  0   *Receptors, Somatostatin. Genomics 1995 Apr 10;26(3):638-9
somatostatin receptor 2  0   *Receptors, Somatostatin. Biochem Biophys Res Commun 1995 May 25;210(3):805-15
somatostatin-28 receptor  0   *Receptors, Somatostatin. Nature 1981;294(5838):259

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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