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Receptors, Thromboxane

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Definition: Cell surface proteins that bind THROMBOXANES with high affinity and trigger intracellular changes influencing the behavior of cells. Some thromboxane receptors act via the inositol phosphate and diacylglycerol second messenger systems.  coord IM with specific thromboxane (IM); RECEPTORS, THROMBOXANE A2 is also available; DF: TP RECEPT   
Examples Receptors, Thromboxane A2, Prostaglandin H2 		Other names Thromboxane Receptors; TP Receptors; Thromboxanes Receptors; Receptors, TP; Receptor, Thromboxane; Receptor, TP; Thromboxane Receptor; TP Receptor; Receptors, Thromboxanes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AGN 204396  0   *Oxazoles *Bicyclo Compounds, Heterocyclic Receptors, Thromboxane/antagonists & inhibitors. Br J Pharmacol 2007 Feb;150(3):342-52
3-((6-amino-(4-chlorobenzenesulfonyl)-2-methyl-5,6,7,8-tetrahydronapht)-1-yl)propionic acid  0   *Naphthalenes *Propionic Acids Receptors, Thromboxane/antagonists & inhibitors. Circulation. 2005 Jan 25;111(3):334-42
N-n-pentyl-N'-(2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl)urea  0   *Aniline Compounds *Sulfonylurea Compounds Thromboxane-A Synthase/antagonists & inhibitors Receptors, Thromboxane/antagonists & inhibitors. J Pharmacol Exp Ther 2005 Apr;313(1):293-301
N-terbutyl-N'-(2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl)urea  0   *Sulfonylurea Compounds Receptors, Thromboxane/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Jul;306(1):59-65
BM 531  0   *Sulfonylurea Compounds Receptors, Thromboxane/antagonists & inhibitors. Prostaglandins Leukot Essent Fatty Acids 2000 May;62(5):311-7
7-(2-(2-aza-2-(((phenylamino)thioxomethyl)amino)vinyl)-4-methyl-3,5-dioxanyl)hept-5-enoic acid  0   *Dioxanes Thiourea/*analogs & derivatives Receptors, Thromboxane/antagonists & inhibitors. Bioorg Med Chem 1999 Nov;7(11):2635-45
BM 500  0   *Sulfonylurea Compounds Receptors, Thromboxane/antagonists & inhibitors. J Pharm Pharmacol 1999 Jun;51(6):695-701
2-(4-chlorophenylsulfonamido)-6-propyl-7-((pyridin-3-yl)methyl)-1,2,3,4-tetrahydronaphthalene-5-propanoic acid  0   *Sulfonamides *Tetrahydronaphthalenes Thromboxane-A Synthase/antagonists & inhibitors Receptors, Thromboxane/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Jun 2;8(11):1381-6
S 1886  0   *Sulfonamides *Tetrahydronaphthalenes Receptors, Thromboxane/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Jun 2;8(11):1375-80
7-(4-(4-(((4-cyclohexylbutyl)amino)carbonyl)-2-oxazolyl)phenyl)-7-(3-pyridyl)hept-6-enoic acid  0   *Heptanoic Acids *Oxazoles Thromboxane-A Synthase/antagonists & inhibitors Receptors, Thromboxane/antagonists & inhibitors. J Med Chem 1998 Dec 31;41(27):5362-74
Z 335  0   *Indans Receptors, Thromboxane/antagonists & inhibitors. Thromb Res 1998 Sep 1;91(5):229-35
S 17733  0   *Heptanoic Acids *Sulfonamides Receptors, Thromboxane/antagonists & inhibitors. Br J Pharmacol 1998 Nov;122(5):859-66
DTTX30  0   *Pyridines *Chlorobenzenes Thromboxane-A Synthase/antagonists & inhibitors Receptors, Thromboxane/antagonists & inhibitors. Basic Res Cardiol 1997 Jun;92(3):181-90
ON 579  141286-14-8   *Phenoxyacetates *Sulfonamides Receptors, Thromboxane/antagonists & inhibitors. Prostaglandins Leukot Essent Fatty Acids 1995 Aug;53(2):123-33
linotroban  120824-08-0   *Acetates *Thiophenes Receptors, Thromboxane/antagonists & inhibitors. Thromb Haemost 1994 Jan;71(1):103-9
ramatroban  116649-85-5 9H-Carbazole-9-propanoic acid, 3-(((4-fluorophenyl)sulfonyl)amino)-1,2,3,4-tetrahydro-, (R)  *Carbazoles *Sulfonamides Receptors, Thromboxane/antagonists & inhibitors.
Pharma Action Platelet Aggregation Inhibitors 		Arzneimittelforschung 1989;39(12):1519
SQ 29548  98299-61-7   *Hydrazines Receptors, Thromboxane/antagonists & inhibitors. Prostaglandins 1985;29(5):785

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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