Definition: High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Other names Protein Tyrosine Phosphatase, Receptor Type, C; Leukocyte Common Antigens; CD45RO Antigens; CD45RA Antigens; CD45R Antigens; CD45 Antigens; L CA Antigens; Antigens, T200; Antigens, Leukocyte Common; Antigens, L-CA; Antigens, CD45RO; Antigens, CD45RB; Antigens, CD45RA; Antigens, CD45R0; Antigens, CD45R; Antigens, B220; Antigens, 2H4; Antigen, Leukocyte Common; Antigen, CD45; Antigen, B220
