encyclopedia of medical concepts
ψ 
ψ 
ψ 

H(+)-K(+)-Exchanging ATPase

More information in Books or onNLM PubMed
Definition: An enzyme isolated from the gastric mucosa that catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions across the cell wall. This enzyme was formerly listed as EC 3.6.1.36.  do not confuse X ref H(+)-K(+)-TRANSPORTING ATPASE with PROTON-TRANSLOCATING ATPASES; DF: H K ATPASE    Other names ATPase, Potassium Hydrogen; ATPase Hydrogen, Potassium; Potassium Hydrogen ATPase; Hydrogen, Potassium, Adenosine Triphosphatase; Adenosine Triphosphatase, Hydrogen, Potassium; Hydrogen, Potassium, Adenosinetriphosphatase; Hydrogen, Potassium ATPase; H(+)-K(+)-Transporting ATPase; Adenosinetriphosphatase, Hydrogen, Potassium; ATPase, Hydrogen, Potassium
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,3-dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo(1,2-h)(1,7)naphthyridine  0   *Imidazoles *Naphthyridines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Biochemistry 2005 Dec 13;44(49):16321-32
2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)imidazo(1,2-a)pyridine-6-carboxamide  0   *Imidazoles *Pyridines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Eur J Pharm Sci 2006 Oct 1;29(2):91-101
8-(2-ethyl-6-methylbenzylamino)-3-hydroxymethyl-2-methylimidazo(1,2-a)pyridine-6-carboxamide  0   *Imidazoles *Pyridines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Eur J Pharm Sci 2006 Oct 1;29(2):91-101
IY 81149  0   *Benzimidazoles *Sulfoxides H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Arch Pharm Res 1999 Apr;22(2):189-93
YJA 20379-6  0   *Quinolines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. J Pharm Pharmacol 1998 May;50(5):521-9
SPI 447  0   *Imidazoles *Pyridines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Jpn J Pharmacol 1997 Nov;75(3):303-6
BY 841  0   *Imidazoles *Pyridines Proton Pumps/antagonists & inhibitors H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Yale J Biol Med 1996 May-Jun;69(3):233-43
T 330  0   *Imidazoles *Pyridines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. J Pharmacol Exp Ther 1996 Apr;277(1):28-33
ethyl 2-((1H-benzimidazol-2-yl)sulfinylmethyl)-4-dimethylamino-5-pyrimidinecarboxylate  0   *Benzimidazoles H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1995 Jan;43(1):166-8
ATP12A protein, human  EC 3.6.3.10   *H(+)-K(+)-Exchanging ATPase. FEBS Lett 1994 Jul 25;349(1):144-50
3-butyryl-4-(2-methylphenylamino)-8-(2-hydroxyethoxy)quinoline  144453-77-0   *Aminoquinolines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. J Chromatogr 1993 Sep 8;619(1):172-6
TY 11345  137927-14-1 5H-Cyclohepta(b)pyridine, 9-(1H-benzimidazol-2-ylsulfinyl)-6,7,8,9-tetrahydro-4-methoxy-, sodium salt  *Benzimidazoles H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Jpn J Pharmacol 1993 Aug;62(4):363-71
3-(3-(ethoxycarbonyl)propionyl)-8-methoxy-4-((2-methylphenyl)amino)quinoline  150907-43-0 3-Quinolinebutanoic acid, 8-methoxy-4-((2-methylphenyl)amino)-gamma-oxo-, ethyl ester  *Aminoquinolines *Succinates H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. J Med Chem 1993 Sep 17;36(19):2828-30
cassigarol A  106387-02-4 5H-Dibenzo(a,d)cycloheptene-2,3,6,8-tetrol, 11-(3,4-dihydroxyphenyl)-5-((3,5-dihydroxyphenyl)methyl)-10,11-dihydro  *Phenols Fibrinolysin/antagonists & inhibitors H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Biochem Pharmacol 1992 Jul 7;44(1):33-7
scopadulciol  136565-26-9 9,11a-Methano-11aH-cyclohepta(a)naphthalen-8(9H)-one, 5-(benzoyloxy)dodecahydro-4-(hydroxymethyl)-4,9,11b-trimethyl-, (4R-(4alpha,4aalpha,5beta,6abeta,9beta,11abeta,11bbeta))  *Diterpenes, Abietane H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. J Nat Prod 1991;54(3):802
1-(2-methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline  122456-37-5   *Aminoquinolines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. J Biol Chem 1991;266(19):12395
xanthoangelol  62949-76-2   Chalcone/*analogs & derivatives H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. J Pharm Pharmacol 1990;42(10):723
SK&F 96464  131666-46-1   *Aminoquinolines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Biochim Biophys Acta 1990;1029(1):24
SK&F 96079  122456-25-1   *Hydroxyquinolines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Biochim Biophys Acta 1990;1029(1):24
salvianolic acid A  96574-01-5   *Caffeic Acids *Lactates Drugs, Chinese Herbal 4-Nitrophenylphosphatase/antagonists & inhibitors H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Planta Med 1990;56(4):360
pantoprazole  102625-70-7 1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)  *2-Pyridinylmethylsulfinylbenzimidazoles H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors.
Pharma Action Anti-Ulcer Agents ; Proton Pump Inhibitors 		Biochem Pharmacol 1990;39(11):1799PROTONIX; PANTOPRAZOLE SODIUM; PROTONIX IV; PANTOPRAZOLE
8-((2-benzimidazolyl)sulfinylmethyl)-1-ethyl-1,2,3,4-tetrahydroquinoline  112644-23-2   *Benzimidazoles *Quinolines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1989;37(8):2109
BY 831-78  123896-32-2 By 831-78  *Benzimidazoles H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Gastroenterology 1989;97(4):846
lansoprazole  103577-45-3   *2-Pyridinylmethylsulfinylbenzimidazoles Proton Pumps/antagonists & inhibitors H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors.
Pharma Action Anti-Infective Agents ; Anti-Ulcer Agents ; Enzyme Inhibitors 		J Pharmacol Exp Ther 1989;248(2):799PREVACID; LANSOPRAZOLE; PREVACID NAPRAPAC 250 (COPACKAGED); PREVACID NAPRAPAC 375 (COPACKAGED); PREVACID IV; DEXILANT; PREVACID 24 HR; PREVACID NAPRAPAC 500 (COPACKAGED)
S 1924  111371-30-3   *Imidazoles H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Pharmacology 1988;36(5):289
2-(2-ethylaminobenzylsulfinyl)-5,6-dimethoxybenzimidazole  108499-48-5   Omeprazole/*analogs & derivatives H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Pharmacology 1988;36(5):289
hydrogen potassium ATPase, gastric endogenous activator protein, mammal  0   *Gastrointestinal Hormones Enzyme Activation H(+)-K(+)-Exchanging ATPase. J Biol Chem 1987;262(12):5664
B 823-10  86604-68-4   *2-Pyridinylmethylsulfinylbenzimidazoles H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Br J Pharmacol 1986;88(2):389

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy