encyclopedia of medical concepts
ψ 
ψ 
ψ 

Receptor, IGF Type 1

More information in Books or onNLM PubMed
Definition: A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.  DF: RECEPT IGF 1   
See Also Insulin-Like Growth Factor I; Insulin-Like Growth Factor II 		Other names Receptor, Insulin-Like Growth Factor Type 1; Receptor, Insulin-Like Growth Factor I; Receptor, IGF-I; IGF-I Receptor; IGF Type 1 Receptor; Receptors, IGF 1; Receptor, IGF-1; Receptor, IGF I; Insulin Like Growth Factor I Receptor; IGF-1 Receptors; IGF I Receptor; IGF 1 Receptor; Receptors, Insulin-Like-Growth Factor I; Receptors, IGF-1; Receptor, IGF Type 1 beta Subunit; Receptor, IGF Type 1 alpha Subunit; Insulin-Like-Growth Factor I Receptor; IGF-1 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-(1-(2-(4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-2-oxo-1,2-dihydropyridin-3-yl)-4-methyl-1H-benzo(d)imidazol-6-yl)piperidin-4-yl)piperazine-1-carboxylate  0   *Benzimidazoles *Piperazines Receptor, IGF Type 1/antagonists & inhibitors. J Pharmacol Exp Ther. 2012 Mar;340(3):688-97.
GTx 134  0   *Heterocyclic Compounds, 3-Ring *Sulfones Receptor, IGF Type 1/antagonists & inhibitors. Clin Cancer Res. 2011 Jul 15;17(14):4693-704.
AZ 12253801  0   *Isoxazoles *Pyrimidines Receptor, IGF Type 1/antagonists & inhibitors. Br J Cancer 2011 Aug 23;105(5):649-57
4-(4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo(f)(1,4)oxazepin-3-ylmethyl)phenol  0   *Oxazepines *Sulfonamides Receptor, IGF Type 1/antagonists & inhibitors. Mol Cell Endocrinol 2011 May 16;338(1-2):68-78
anti-IGF-1R antibody A12  0   *Antibodies, Monoclonal Radiation-Sensitizing Agents Receptor, IGF Type 1. Int J Radiat Oncol Biol Phys. 2011 Mar 15;79(4):1179-87
GSK 1838705A  0   *Pyrimidines *Pyrroles Receptor, IGF Type 1/antagonists & inhibitors. Mol Cancer Ther 2009 Oct;8(10):2811-20
M1557 peptide  0   *Peptides Receptor, IGF Type 1/antagonists & inhibitors. Mol Cancer 2008;7:17

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy